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- W4385607029 abstract "The ability of psychedelic compounds to profoundly alter mental function has been long known, but the underlying changes in cellular-level information encoding remain poorly understood. We used 2-photon microscopy to record from the retrosplenial cortex (RSC) in head-fixed mice running on a treadmill before and after injection of the non-classic psychedelic ibogaine (40 mg/kg i.p.). We found that the cognitive map, formed by the representation of position encoded by ensembles of individual neurons in the RSC, was destabilized by ibogaine when mice had to infer position between tactile landmarks. This corresponded with increased neural activity rates, loss of correlation structure, and increased responses to cues. Ibogaine had surprisingly little effect on the size-frequency distribution of network activity events, suggesting that signal propagation within RSC was largely unaffected. Together, these data support proposals that compounds with psychedelic properties disrupt representations important for constraining neocortical activity, thereby increasing the entropy of neural signaling. Furthermore, the loss of expected position encoding between landmarks recapitulated effects of hippocampal impairment, suggesting that disruption of cognitive maps or other hippocampal processing may be a contributing mechanism of discoordinated neocortical activity in psychedelic states." @default.
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- W4385607029 date "2023-08-01" @default.
- W4385607029 modified "2023-10-17" @default.
- W4385607029 title "The Nonclassic Psychedelic Ibogaine Disrupts Cognitive Maps" @default.
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- W4385607029 doi "https://doi.org/10.1016/j.bpsgos.2023.07.008" @default.
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