FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385609511> ?p ?o ?g. }

• W4385609511 abstract "Abstract Background Malignant cells adopt anoikis resistance to survive anchorage-free stresses and initiate cancer metastasis. It is still unknown how varying periods of anchorage loss contribute to anoikis resistance, cell migration, and metabolic reprogramming of cancerous cells. Results Our study demonstrated that prolonging the anchorage-free lifetime of non-small-cell lung cancer NCI-H460 cells for 7 days strengthened anoikis resistance, as shown by higher half-life and capability to survive and grow without anchorage, compared to wild-type cells or those losing anchorage for 3 days. While the prolonged anchorage-free lifetime was responsible for the increased aggressive feature of survival cells to perform rapid 3-dimensional migration during the first 3 h of a transwell assay, no significant influence was observed with 2-dimensional surface migration detected at 12 and 24 h by a wound-healing method. Metabolomics analysis revealed significant alteration in the intracellular levels of six (oxalic acid, cholesterol, 1-ethylpyrrolidine, 1-(3-methylbutyl)-2,3,4,6-tetramethylbenzene, β-alanine, and putrescine) among all 37 identified metabolites during 7 days without anchorage. Based on significance values, enrichment ratios, and impact scores of all metabolites and their associated pathways, three principal metabolic activities (non-standard amino acid metabolism, cell membrane biosynthesis, and oxidative stress response) offered potential links with anoikis resistance. Conclusions These findings further our insights into the evolution of anoikis resistance in lung cancer cells and identify promising biomarkers for early lung cancer diagnosis." @default.
• W4385609511 created "2023-08-06" @default.
• W4385609511 creator A5019794851 @default.
• W4385609511 creator A5022507789 @default.
• W4385609511 creator A5023157115 @default.
• W4385609511 creator A5037504590 @default.
• W4385609511 creator A5049008934 @default.
• W4385609511 creator A5068798384 @default.
• W4385609511 date "2023-08-05" @default.
• W4385609511 modified "2023-10-18" @default.
• W4385609511 title "How do prolonged anchorage-free lifetimes strengthen non-small-cell lung cancer cells to evade anoikis? – A link with altered cellular metabolomics" @default.
• W4385609511 cites W1543068333 @default.
• W4385609511 cites W1853799828 @default.
• W4385609511 cites W19540828 @default.
• W4385609511 cites W1974251566 @default.
• W4385609511 cites W1982183527 @default.
• W4385609511 cites W1990420218 @default.
• W4385609511 cites W1992831404 @default.
• W4385609511 cites W2019402080 @default.
• W4385609511 cites W2023465240 @default.
• W4385609511 cites W2023947368 @default.
• W4385609511 cites W2038982031 @default.
• W4385609511 cites W2039403501 @default.
• W4385609511 cites W2069741520 @default.
• W4385609511 cites W2080693092 @default.
• W4385609511 cites W2080943203 @default.
• W4385609511 cites W2084465684 @default.
• W4385609511 cites W2095938297 @default.
• W4385609511 cites W2100963171 @default.
• W4385609511 cites W2113876813 @default.
• W4385609511 cites W2115124692 @default.
• W4385609511 cites W2144884298 @default.
• W4385609511 cites W2155020484 @default.
• W4385609511 cites W2321170268 @default.
• W4385609511 cites W2345968351 @default.
• W4385609511 cites W2415630854 @default.
• W4385609511 cites W2475015499 @default.
• W4385609511 cites W2763871199 @default.
• W4385609511 cites W2774680582 @default.
• W4385609511 cites W2784371446 @default.
• W4385609511 cites W2788640168 @default.
• W4385609511 cites W2887589291 @default.
• W4385609511 cites W2898529188 @default.
• W4385609511 cites W2917105999 @default.
• W4385609511 cites W2923046924 @default.
• W4385609511 cites W2946136668 @default.
• W4385609511 cites W2946847644 @default.
• W4385609511 cites W2947780266 @default.
• W4385609511 cites W3011019824 @default.
• W4385609511 cites W3021305296 @default.
• W4385609511 cites W3102288871 @default.
• W4385609511 cites W3120320954 @default.
• W4385609511 cites W3144812939 @default.
• W4385609511 cites W3164256537 @default.
• W4385609511 cites W3164375898 @default.
• W4385609511 cites W3175283097 @default.
• W4385609511 cites W3186096673 @default.
• W4385609511 cites W3204564031 @default.
• W4385609511 cites W4200109539 @default.
• W4385609511 cites W4200407607 @default.
• W4385609511 cites W4210300668 @default.
• W4385609511 cites W4282930066 @default.
• W4385609511 cites W4303614319 @default.
• W4385609511 cites W4308058256 @default.
• W4385609511 cites W2338778792 @default.
• W4385609511 doi "https://doi.org/10.1186/s40659-023-00456-z" @default.
• W4385609511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37542350" @default.
• W4385609511 hasPublicationYear "2023" @default.
• W4385609511 type Work @default.
• W4385609511 citedByCount "0" @default.
• W4385609511 crossrefType "journal-article" @default.
• W4385609511 hasAuthorship W4385609511A5019794851 @default.
• W4385609511 hasAuthorship W4385609511A5022507789 @default.
• W4385609511 hasAuthorship W4385609511A5023157115 @default.
• W4385609511 hasAuthorship W4385609511A5037504590 @default.
• W4385609511 hasAuthorship W4385609511A5049008934 @default.
• W4385609511 hasAuthorship W4385609511A5068798384 @default.
• W4385609511 hasBestOaLocation W43856095111 @default.
• W4385609511 hasConcept C121608353 @default.
• W4385609511 hasConcept C126322002 @default.
• W4385609511 hasConcept C1491633281 @default.
• W4385609511 hasConcept C152000582 @default.
• W4385609511 hasConcept C185592680 @default.
• W4385609511 hasConcept C20251656 @default.
• W4385609511 hasConcept C21565614 @default.
• W4385609511 hasConcept C2776256026 @default.
• W4385609511 hasConcept C2779013556 @default.
• W4385609511 hasConcept C502942594 @default.
• W4385609511 hasConcept C54355233 @default.
• W4385609511 hasConcept C55493867 @default.
• W4385609511 hasConcept C60644358 @default.
• W4385609511 hasConcept C62231903 @default.
• W4385609511 hasConcept C71924100 @default.
• W4385609511 hasConcept C79879829 @default.
• W4385609511 hasConcept C86803240 @default.
• W4385609511 hasConcept C95444343 @default.
• W4385609511 hasConcept C96232424 @default.
• W4385609511 hasConceptScore W4385609511C121608353 @default.
• W4385609511 hasConceptScore W4385609511C126322002 @default.
• W4385609511 hasConceptScore W4385609511C1491633281 @default.

• next