FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385612079> ?p ?o ?g. }

• W4385612079 abstract "Context: Global reports have revealed a dramatic rise in the number of patients diagnosed with type 2 diabetes (T2DM) over the past three decades in all age groups, even in children and adolescents. The physiologic phenomenon of insulin resistance during puberty, as well as genetic and epigenetic factors, are implicated in this phenomenon. It seems that patients with early-onset T2DM experience a more aggressive clinical course; however, limited treatments available for these patients pose a challenge. This narrative review intends to scrutinize the micro- and macrovascular complications and treatments of patients with early-onset T2DM. Methods: The literature search was conducted in the PubMed database to identify all relevant original English articles published from the beginning of 2018 until January 2023. Results: Vascular complications, such as albuminuria, hypertension, cardiovascular diseases, and retinopathy, were seen to be more common in early-onset T2DM compared to type 1 diabetes. The odds ratio of vascular complications was higher in early-onset compared to late-onset T2DM. In children and adolescents with T2DM, the only approved medications included metformin, insulin, and glucagon-like peptide-1 agonists. Treatment of early-onset T2DM with metformin monotherapy cannot yield durable glycemic control, and most patients need early combination therapy. Conclusions: During the past years, the frequency of early-onset T2DM has been growing at an alarming rate. Vascular complications in these patients seem more aggressive and more challenging to control. Hence, further clinical trials should be conducted to develop novel therapeutic approaches and evaluate their long-term benefits in terms of glycemic control and preventing future complications." @default.
• W4385612079 created "2023-08-06" @default.
• W4385612079 creator A5044771761 @default.
• W4385612079 creator A5058001468 @default.
• W4385612079 creator A5068459979 @default.
• W4385612079 creator A5092788731 @default.
• W4385612079 date "2023-08-06" @default.
• W4385612079 modified "2023-10-18" @default.
• W4385612079 title "Complications and Treatment of Early-Onset Type 2 Diabetes" @default.
• W4385612079 cites W2748764116 @default.
• W4385612079 cites W2781721819 @default.
• W4385612079 cites W2792939285 @default.
• W4385612079 cites W2797249179 @default.
• W4385612079 cites W2913433013 @default.
• W4385612079 cites W2941570251 @default.
• W4385612079 cites W2942388295 @default.
• W4385612079 cites W2954889637 @default.
• W4385612079 cites W2970546134 @default.
• W4385612079 cites W2977137554 @default.
• W4385612079 cites W2980447543 @default.
• W4385612079 cites W2993697823 @default.
• W4385612079 cites W3003052690 @default.
• W4385612079 cites W3034086512 @default.
• W4385612079 cites W3039310866 @default.
• W4385612079 cites W3040107123 @default.
• W4385612079 cites W3043821401 @default.
• W4385612079 cites W3046970115 @default.
• W4385612079 cites W3100074424 @default.
• W4385612079 cites W3120577305 @default.
• W4385612079 cites W3124521052 @default.
• W4385612079 cites W3156872463 @default.
• W4385612079 cites W3160575109 @default.
• W4385612079 cites W3195594956 @default.
• W4385612079 cites W3195623378 @default.
• W4385612079 cites W3199255791 @default.
• W4385612079 cites W3201957978 @default.
• W4385612079 cites W3210711974 @default.
• W4385612079 cites W3211875645 @default.
• W4385612079 cites W3213440893 @default.
• W4385612079 cites W4200225318 @default.
• W4385612079 cites W4206923789 @default.
• W4385612079 cites W4206941834 @default.
• W4385612079 cites W4210581174 @default.
• W4385612079 cites W4210624864 @default.
• W4385612079 cites W4220900190 @default.
• W4385612079 cites W4223949047 @default.
• W4385612079 cites W4224985575 @default.
• W4385612079 cites W4247351494 @default.
• W4385612079 cites W4251173987 @default.
• W4385612079 cites W4281788945 @default.
• W4385612079 cites W4283705580 @default.
• W4385612079 cites W4286001965 @default.
• W4385612079 cites W4293509620 @default.
• W4385612079 cites W4296423266 @default.
• W4385612079 doi "https://doi.org/10.5812/ijem-135004" @default.
• W4385612079 hasPublicationYear "2023" @default.
• W4385612079 type Work @default.
• W4385612079 citedByCount "0" @default.
• W4385612079 crossrefType "journal-article" @default.
• W4385612079 hasAuthorship W4385612079A5044771761 @default.
• W4385612079 hasAuthorship W4385612079A5058001468 @default.
• W4385612079 hasAuthorship W4385612079A5068459979 @default.
• W4385612079 hasAuthorship W4385612079A5092788731 @default.
• W4385612079 hasBestOaLocation W43856120791 @default.
• W4385612079 hasConcept C126322002 @default.
• W4385612079 hasConcept C134018914 @default.
• W4385612079 hasConcept C151730666 @default.
• W4385612079 hasConcept C187212893 @default.
• W4385612079 hasConcept C2777180221 @default.
• W4385612079 hasConcept C2777391703 @default.
• W4385612079 hasConcept C2779306644 @default.
• W4385612079 hasConcept C2779343474 @default.
• W4385612079 hasConcept C2780323712 @default.
• W4385612079 hasConcept C2780473172 @default.
• W4385612079 hasConcept C2910068830 @default.
• W4385612079 hasConcept C555293320 @default.
• W4385612079 hasConcept C71924100 @default.
• W4385612079 hasConcept C86803240 @default.
• W4385612079 hasConceptScore W4385612079C126322002 @default.
• W4385612079 hasConceptScore W4385612079C134018914 @default.
• W4385612079 hasConceptScore W4385612079C151730666 @default.
• W4385612079 hasConceptScore W4385612079C187212893 @default.
• W4385612079 hasConceptScore W4385612079C2777180221 @default.
• W4385612079 hasConceptScore W4385612079C2777391703 @default.
• W4385612079 hasConceptScore W4385612079C2779306644 @default.
• W4385612079 hasConceptScore W4385612079C2779343474 @default.
• W4385612079 hasConceptScore W4385612079C2780323712 @default.
• W4385612079 hasConceptScore W4385612079C2780473172 @default.
• W4385612079 hasConceptScore W4385612079C2910068830 @default.
• W4385612079 hasConceptScore W4385612079C555293320 @default.
• W4385612079 hasConceptScore W4385612079C71924100 @default.
• W4385612079 hasConceptScore W4385612079C86803240 @default.
• W4385612079 hasIssue "3" @default.
• W4385612079 hasLocation W43856120791 @default.
• W4385612079 hasOpenAccess W4385612079 @default.
• W4385612079 hasPrimaryLocation W43856120791 @default.
• W4385612079 hasRelatedWork W1993604690 @default.
• W4385612079 hasRelatedWork W2017470589 @default.
• W4385612079 hasRelatedWork W2080042754 @default.
• W4385612079 hasRelatedWork W2109371472 @default.

• next