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- W4385612886 endingPage "102029" @default.
- W4385612886 startingPage "102029" @default.
- W4385612886 abstract "Dementia is prevalent in aged populations and is associated with disability and distress for those affected. Therapeutic benefits of drugs targeting dementia are small. Impaired nutrient sensing pathways have been implicated in the pathogenesis of dementia and may offer a novel treatment target.This systematic review collated evidence for novel therapeutic compounds that modify nutrient sensing pathways, particularly the sirtuin pathway, in preventing cognitive decline or improving cognition in normal ageing, mild cognitive impairment (MCI), and dementia.PubMed, Embase and Web of Science databases were searched using key search terms. Articles were screened using Covidence systematic review software. The risk of bias was assessed using the Systematic Review Center for Laboratory animal Experimentation (SYRCLE)'s risk of bias tool for animal studies and Cochrane Risk of Bias tool v 2.0 for human studies.Out of 3841 articles, 68 were included describing 38 different novel therapeutic compounds that modulate the nutrient sensing pathway via the sirtuin pathway. In animal models (58 studies), all investigated novel therapeutic compounds showed cognitive benefits. Ten studies were human intervention trials targeting normal ageing (1 study) and dementia populations (9 studies). Direct sirtuin (silent mating type information regulation 2 homolog) 1 (SIRT1) activators Resveratrol and Nicotinamide derivatives improved cognitive outcomes among human subjects with normal cognition and MCI.Animal studies support that modulation of the sirtuin pathway has the potential to improve cognitive outcomes. Overall, there is a clear lack of translation from animal models to human populations." @default.
- W4385612886 created "2023-08-07" @default.
- W4385612886 creator A5015665688 @default.
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- W4385612886 creator A5039684678 @default.
- W4385612886 creator A5053545069 @default.
- W4385612886 creator A5062169644 @default.
- W4385612886 date "2023-09-01" @default.
- W4385612886 modified "2023-09-26" @default.
- W4385612886 title "Targeting impaired nutrient sensing via the sirtuin pathway with novel compounds to prevent or treat dementia: A systematic review" @default.
- W4385612886 cites W1833173427 @default.
- W4385612886 cites W1922973595 @default.
- W4385612886 cites W1948460491 @default.
- W4385612886 cites W1971805828 @default.
- W4385612886 cites W1990696348 @default.
- W4385612886 cites W2003441551 @default.
- W4385612886 cites W2006097728 @default.
- W4385612886 cites W2007557482 @default.
- W4385612886 cites W2012529359 @default.
- W4385612886 cites W2017123784 @default.
- W4385612886 cites W2020774181 @default.
- W4385612886 cites W2023411987 @default.
- W4385612886 cites W2028247429 @default.
- W4385612886 cites W2034578326 @default.
- W4385612886 cites W2036814520 @default.
- W4385612886 cites W2048970899 @default.
- W4385612886 cites W2051126208 @default.
- W4385612886 cites W2058571677 @default.
- W4385612886 cites W2067843777 @default.
- W4385612886 cites W2068267549 @default.
- W4385612886 cites W2069369322 @default.
- W4385612886 cites W2070708146 @default.
- W4385612886 cites W2072826174 @default.
- W4385612886 cites W2074929556 @default.
- W4385612886 cites W2085307289 @default.
- W4385612886 cites W2089216251 @default.
- W4385612886 cites W2089740883 @default.
- W4385612886 cites W2093579804 @default.
- W4385612886 cites W2119282881 @default.
- W4385612886 cites W2126525177 @default.
- W4385612886 cites W2156683441 @default.
- W4385612886 cites W2160427616 @default.
- W4385612886 cites W2182158572 @default.
- W4385612886 cites W2258702834 @default.
- W4385612886 cites W2405840972 @default.
- W4385612886 cites W2475113336 @default.
- W4385612886 cites W2521579340 @default.
- W4385612886 cites W2553742787 @default.
- W4385612886 cites W2574949547 @default.
- W4385612886 cites W2577488731 @default.
- W4385612886 cites W2588366160 @default.
- W4385612886 cites W2592199539 @default.
- W4385612886 cites W2752566882 @default.
- W4385612886 cites W2757416034 @default.
- W4385612886 cites W2762327949 @default.
- W4385612886 cites W2763984329 @default.
- W4385612886 cites W2766447282 @default.
- W4385612886 cites W2773834101 @default.
- W4385612886 cites W2784304925 @default.
- W4385612886 cites W2793422823 @default.
- W4385612886 cites W2796075038 @default.
- W4385612886 cites W2806094500 @default.
- W4385612886 cites W2806933589 @default.
- W4385612886 cites W2807998160 @default.
- W4385612886 cites W2884470777 @default.
- W4385612886 cites W2890276233 @default.
- W4385612886 cites W2898879641 @default.
- W4385612886 cites W2902267205 @default.
- W4385612886 cites W2902400140 @default.
- W4385612886 cites W2902420995 @default.
- W4385612886 cites W2904217420 @default.
- W4385612886 cites W2911448712 @default.
- W4385612886 cites W2911504008 @default.
- W4385612886 cites W2922495100 @default.
- W4385612886 cites W2944852416 @default.
- W4385612886 cites W2981624110 @default.
- W4385612886 cites W2997318819 @default.
- W4385612886 cites W3007744184 @default.
- W4385612886 cites W3012205063 @default.
- W4385612886 cites W3018847838 @default.
- W4385612886 cites W3034636056 @default.
- W4385612886 cites W3038054969 @default.
- W4385612886 cites W3043746766 @default.
- W4385612886 cites W3045889124 @default.
- W4385612886 cites W3047910909 @default.
- W4385612886 cites W3097811525 @default.
- W4385612886 cites W3110333380 @default.
- W4385612886 cites W3110672216 @default.
- W4385612886 cites W3116688332 @default.
- W4385612886 cites W3116841515 @default.
- W4385612886 cites W3152722365 @default.
- W4385612886 cites W3158085113 @default.
- W4385612886 cites W3171702175 @default.
- W4385612886 cites W4200268848 @default.
- W4385612886 cites W4220990745 @default.
- W4385612886 cites W4224989418 @default.
- W4385612886 cites W4294833428 @default.
- W4385612886 cites W4312406940 @default.