Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385612899> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W4385612899 abstract "Abstract Motivation: Recent advances in spatially resolved transcriptomics (ST) technologies enable the measurement of gene expression profiles while preserving cellular spatial context. Linking gene expression of cells with their spatial distribution is essential for better understanding of tissue microenvironment and biological progress. However, effectively combining gene expression data with spatial information to identify spatial domains remains challenging. Results: To deal with the above issue, in this paper, we propose a novel unsupervised learning framework named STMGCN for identifying spatial domains using multi-view graph convolution networks (MGCNs). Specifically, to fully exploit spatial information, we first construct multiple neighbor graphs (views) with different similarity measures based on the spatial coordinates. Then, STMGCN learns multiple view-specific embeddings by combining gene expressions with each neighbor graph through graph convolution networks. Finally, to capture the importance of different graphs, we further introduce an attention mechanism to adaptively fuse view-specific embeddings and thus derive the final spot embedding. STMGCN allows for the effective utilization of spatial context to enhance the expressive power of the latent embeddings with multiple graph convolutions. We apply STMGCN on two simulation datasets and five real spatial transcriptomics datasets with different resolutions across distinct platforms. The experimental results demonstrate that STMGCN obtains competitive results in spatial domain identification compared with five state-of-the-art methods, including spatial and non-spatial alternatives. Besides, STMGCN can detect spatially variable genes with enriched expression patterns in the identified domains. Overall, STMGCN is a powerful and efficient computational framework for identifying spatial domains in spatial transcriptomics data." @default.
- W4385612899 created "2023-08-07" @default.
- W4385612899 creator A5006165246 @default.
- W4385612899 creator A5034398262 @default.
- W4385612899 creator A5046165905 @default.
- W4385612899 creator A5066627747 @default.
- W4385612899 date "2023-08-07" @default.
- W4385612899 modified "2023-10-14" @default.
- W4385612899 title "Identifying spatial domains of spatially resolved transcriptomics via multi-view graph convolutional networks" @default.
- W4385612899 cites W2042789810 @default.
- W4385612899 cites W2073654208 @default.
- W4385612899 cites W2123273050 @default.
- W4385612899 cites W2126537932 @default.
- W4385612899 cites W2131681506 @default.
- W4385612899 cites W2800392236 @default.
- W4385612899 cites W2899224111 @default.
- W4385612899 cites W2915848182 @default.
- W4385612899 cites W2952383043 @default.
- W4385612899 cites W2953036966 @default.
- W4385612899 cites W2972983657 @default.
- W4385612899 cites W3021920958 @default.
- W4385612899 cites W3033415403 @default.
- W4385612899 cites W3036371598 @default.
- W4385612899 cites W3094217342 @default.
- W4385612899 cites W3099810371 @default.
- W4385612899 cites W3108118546 @default.
- W4385612899 cites W3112563877 @default.
- W4385612899 cites W3126958162 @default.
- W4385612899 cites W3134482219 @default.
- W4385612899 cites W3181253984 @default.
- W4385612899 cites W3190202966 @default.
- W4385612899 cites W3203689742 @default.
- W4385612899 cites W3210002151 @default.
- W4385612899 cites W4229033508 @default.
- W4385612899 cites W4280604745 @default.
- W4385612899 cites W4285388882 @default.
- W4385612899 cites W4290154117 @default.
- W4385612899 cites W4306406844 @default.
- W4385612899 cites W4322738920 @default.
- W4385612899 cites W4323044112 @default.
- W4385612899 doi "https://doi.org/10.1093/bib/bbad278" @default.
- W4385612899 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37544658" @default.
- W4385612899 hasPublicationYear "2023" @default.
- W4385612899 type Work @default.
- W4385612899 citedByCount "0" @default.
- W4385612899 crossrefType "journal-article" @default.
- W4385612899 hasAuthorship W4385612899A5006165246 @default.
- W4385612899 hasAuthorship W4385612899A5034398262 @default.
- W4385612899 hasAuthorship W4385612899A5046165905 @default.
- W4385612899 hasAuthorship W4385612899A5066627747 @default.
- W4385612899 hasConcept C105795698 @default.
- W4385612899 hasConcept C124101348 @default.
- W4385612899 hasConcept C132525143 @default.
- W4385612899 hasConcept C151730666 @default.
- W4385612899 hasConcept C153180895 @default.
- W4385612899 hasConcept C154945302 @default.
- W4385612899 hasConcept C159620131 @default.
- W4385612899 hasConcept C2779343474 @default.
- W4385612899 hasConcept C33923547 @default.
- W4385612899 hasConcept C41008148 @default.
- W4385612899 hasConcept C41608201 @default.
- W4385612899 hasConcept C64754055 @default.
- W4385612899 hasConcept C80444323 @default.
- W4385612899 hasConcept C86803240 @default.
- W4385612899 hasConceptScore W4385612899C105795698 @default.
- W4385612899 hasConceptScore W4385612899C124101348 @default.
- W4385612899 hasConceptScore W4385612899C132525143 @default.
- W4385612899 hasConceptScore W4385612899C151730666 @default.
- W4385612899 hasConceptScore W4385612899C153180895 @default.
- W4385612899 hasConceptScore W4385612899C154945302 @default.
- W4385612899 hasConceptScore W4385612899C159620131 @default.
- W4385612899 hasConceptScore W4385612899C2779343474 @default.
- W4385612899 hasConceptScore W4385612899C33923547 @default.
- W4385612899 hasConceptScore W4385612899C41008148 @default.
- W4385612899 hasConceptScore W4385612899C41608201 @default.
- W4385612899 hasConceptScore W4385612899C64754055 @default.
- W4385612899 hasConceptScore W4385612899C80444323 @default.
- W4385612899 hasConceptScore W4385612899C86803240 @default.
- W4385612899 hasFunder F4320321001 @default.
- W4385612899 hasFunder F4320324174 @default.
- W4385612899 hasIssue "5" @default.
- W4385612899 hasLocation W43856128991 @default.
- W4385612899 hasLocation W43856128992 @default.
- W4385612899 hasOpenAccess W4385612899 @default.
- W4385612899 hasPrimaryLocation W43856128991 @default.
- W4385612899 hasRelatedWork W114159251 @default.
- W4385612899 hasRelatedWork W1982547614 @default.
- W4385612899 hasRelatedWork W2923818335 @default.
- W4385612899 hasRelatedWork W3035116611 @default.
- W4385612899 hasRelatedWork W3044354590 @default.
- W4385612899 hasRelatedWork W3094605108 @default.
- W4385612899 hasRelatedWork W4226361842 @default.
- W4385612899 hasRelatedWork W4287763734 @default.
- W4385612899 hasRelatedWork W4310879833 @default.
- W4385612899 hasRelatedWork W601889138 @default.
- W4385612899 hasVolume "24" @default.
- W4385612899 isParatext "false" @default.
- W4385612899 isRetracted "false" @default.
- W4385612899 workType "article" @default.