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- W4385613118 endingPage "739976" @default.
- W4385613118 startingPage "739976" @default.
- W4385613118 abstract "This study is aimed to explore the mechanism of overcrowding stress on the immunity of grass carp Ctenopharyngodon idella. Fish were reared for 120 days at 10 kg/m3 (low stocking density, LSD), 15 kg/m3 (medium stocking density, MSD) and 20 kg/m3 (high stocking density, HSD). The results showed that HSD significantly increased the serum cortisol level, implying that fish reared at higher density were subjected to physiological stress. HSD led to a remarkable decline in serum lysozyme activity. The conspicuous decrease of serum complement 3 (C3) and immunoglobulin M (IgM) contents also appeared in the HSD group. The serum antioxidant enzymes activity included total antioxidant capacity (T-AOC), total superoxide dismutase (T-SOD), glutathione peroxidase (GPx), and catalase (CAT) of fish reared at HSD group were clearly decreased. The serum glutathione (GSH) concentration of fish reared at HSD group was notably reduced. The malondialdehyde (MDA) level was obviously increased in HSD group. Long-term crowding stress gave rise to the constitution of melano-macrophage centers in spleen. The transcriptional levels of TLR4/NF-κB signaling pathway were notably up-regulated except for iκbα and mTOR pathway related genes were prominently down-regulated in fish reared at HSD group. The notably up-regulated pro-inflammatory cytokines (tnf-α, ifnγ2, il1-β, and il-8) except for il-6 and prominently down-regulated anti-inflammatory cytokines (il-10, il4/13a, il4/13b, tgf-β1 and tgf-β2) appeared in HSD group. All of the above results revealed that chronic overcrowding stress induced unbalanced inflammatory response via TLR4/NF-κB and mTOR signaling pathway and decreased the immunity in grass carp." @default.
- W4385613118 created "2023-08-07" @default.
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- W4385613118 date "2023-12-01" @default.
- W4385613118 modified "2023-09-26" @default.
- W4385613118 title "Long-term crowding stress induces chronic inflammatory response and declines the immunity of grass carp (Ctenopharyngodon idella)" @default.
- W4385613118 cites W1491813112 @default.
- W4385613118 cites W1520133154 @default.
- W4385613118 cites W1592037392 @default.
- W4385613118 cites W1608239693 @default.
- W4385613118 cites W1611555726 @default.
- W4385613118 cites W1655860314 @default.
- W4385613118 cites W191793640 @default.
- W4385613118 cites W1961179371 @default.
- W4385613118 cites W1963590909 @default.
- W4385613118 cites W1964147516 @default.
- W4385613118 cites W1967859192 @default.
- W4385613118 cites W1972849438 @default.
- W4385613118 cites W1978378281 @default.
- W4385613118 cites W1983310681 @default.
- W4385613118 cites W1985061962 @default.
- W4385613118 cites W1985144728 @default.
- W4385613118 cites W1985507866 @default.
- W4385613118 cites W1990457373 @default.
- W4385613118 cites W1992548312 @default.
- W4385613118 cites W1992667016 @default.
- W4385613118 cites W1996311210 @default.
- W4385613118 cites W1997215979 @default.
- W4385613118 cites W1998106597 @default.
- W4385613118 cites W1998782761 @default.
- W4385613118 cites W2002062788 @default.
- W4385613118 cites W2004821229 @default.
- W4385613118 cites W2008650575 @default.
- W4385613118 cites W2009839595 @default.
- W4385613118 cites W2012443958 @default.
- W4385613118 cites W2014308472 @default.
- W4385613118 cites W2014427980 @default.
- W4385613118 cites W2014883871 @default.
- W4385613118 cites W2016755802 @default.
- W4385613118 cites W2019982824 @default.
- W4385613118 cites W2020920210 @default.
- W4385613118 cites W2022455493 @default.
- W4385613118 cites W2026873686 @default.
- W4385613118 cites W2033063412 @default.
- W4385613118 cites W2037725232 @default.
- W4385613118 cites W2039420141 @default.
- W4385613118 cites W2039708123 @default.
- W4385613118 cites W2042433863 @default.
- W4385613118 cites W2048965213 @default.
- W4385613118 cites W2050201002 @default.
- W4385613118 cites W2053864313 @default.
- W4385613118 cites W2055192262 @default.
- W4385613118 cites W2055773854 @default.
- W4385613118 cites W2055863120 @default.
- W4385613118 cites W2058169080 @default.
- W4385613118 cites W2059540917 @default.
- W4385613118 cites W2073034575 @default.
- W4385613118 cites W2073505294 @default.
- W4385613118 cites W2073539156 @default.
- W4385613118 cites W2078664576 @default.
- W4385613118 cites W2080891415 @default.
- W4385613118 cites W2086355394 @default.
- W4385613118 cites W2086420361 @default.
- W4385613118 cites W2093421766 @default.
- W4385613118 cites W2094595062 @default.
- W4385613118 cites W2096401930 @default.
- W4385613118 cites W2104213630 @default.
- W4385613118 cites W2107315506 @default.
- W4385613118 cites W2108962195 @default.
- W4385613118 cites W2118519973 @default.
- W4385613118 cites W2131646826 @default.
- W4385613118 cites W2145066739 @default.
- W4385613118 cites W2145217162 @default.
- W4385613118 cites W2149250436 @default.
- W4385613118 cites W2156414024 @default.
- W4385613118 cites W2315318536 @default.
- W4385613118 cites W2530790166 @default.
- W4385613118 cites W2560430650 @default.
- W4385613118 cites W2592130254 @default.
- W4385613118 cites W2606159927 @default.
- W4385613118 cites W2615135231 @default.
- W4385613118 cites W2616867802 @default.
- W4385613118 cites W2735155827 @default.
- W4385613118 cites W2781744439 @default.
- W4385613118 cites W2808283382 @default.
- W4385613118 cites W2809867328 @default.
- W4385613118 cites W2811379982 @default.
- W4385613118 cites W2883980640 @default.
- W4385613118 cites W2890127217 @default.