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• W4385617583 endingPage "127470" @default.
• W4385617583 startingPage "127470" @default.
• W4385617583 abstract "The gut microbiota plays a critical role in the appropriate development and maintenance of the enteric nervous system (ENS). Esophageal achalasia (EA) is a rare motility disorder characterized by the selective degeneration of inhibitory neurons in the esophageal myenteric plexus. This study aimed to evaluate the composition of the esophageal microbiota in achalasia and explore the potential microbial mechanisms involved in its pathogenesis. The lower esophageal mucosal microbiota was analyzed in patients with achalasia and control participants using 16 S rRNA sequencing. The association between the esophageal microbiota and achalasia was validated by inducing esophageal dysbiosis in C57BL/10 J and C57BL/10ScNJ (TLR4KO) mice via chronic exposure to ampicillin sodium in their drinking water. The esophageal microbiota in EA patients had lower diversity and a predominance of Gram-negative bacteria (Type II microbiota) compared to that in the healthy controls. Additionally, the relative abundance of Rhodobacter decreased significantly in patients with achalasia, which correlated with an enrichment of lipopolysaccharide (LPS) biosynthesis based on the COG database. Antibiotic-treated mice showed an esophageal microbiota characterized by increased abundance of Gram-negative bacteria (Type II microbiome), decreased abundance of Rhodobacter, and enriched LPS biosynthesis. Compared to the control and TLR4KO mice, the antibiotic-treated wild-type mice had higher LES resting pressure, increased LES contraction rate after carbachol stimulation, and decreased relaxation response to L-arginine. Moreover, the number of myenteric neurons decreased, while the number of lamina propria macrophages (LpMs) increased after antibiotic exposure. Furthermore, the TLR4-MYD88-NF-κB pathway was up-regulated, and the production of TNF-α, IL-1β, and IL-6 increased in the antibiotic-treated mice. Patients with achalasia exhibit esophageal dysbiosis, which may induce aberrant esophageal motility." @default.
• W4385617583 created "2023-08-07" @default.
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• W4385617583 date "2023-11-01" @default.
• W4385617583 modified "2023-10-17" @default.
• W4385617583 title "The role of type II esophageal microbiota in achalasia: Activation of macrophages and degeneration of myenteric neurons" @default.
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• W4385617583 doi "https://doi.org/10.1016/j.micres.2023.127470" @default.
• W4385617583 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37574627" @default.
• W4385617583 hasPublicationYear "2023" @default.
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