Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385620149> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W4385620149 abstract "Network pharmacology and bioinformatics were used to study puerarin's molecular mechanism in treating osteoarthritis from the perspective of ferroptosis, revealing a new treatment target. Ferroptosis-related targets were obtained from FerrDb. Puerarin action targets were retrieved from TCMSP, Pharmmappe, SwissTargetPrediction, and Targetnet databases, and supplemented with PubMed. The gene expression profiles of GSE12021, GSE55235, and GSE82107 were obtained using Osteoarthritis as the search term in the GEO database, and the differential expression gene screening analysis was performed for osteoarthritis. The intersection targets between puerarin, iron death, and osteoarthritis were obtained using Venn diagrams. GO and KEGG analyses were conducted with R software. Molecular docking and visualization of puerarin and core targets were performed using Autodock Vina and PyMol software. The effects of puerarin on the cell viability and the TNFα, IL6, and Ilβ levels of human inflammation articular chondrocytes were tested in vitro experiments. Puerarin, ferroptosis, and osteoarthritis share four targets: PLIN2, PTGS2, VEGFA, and IL6. GO enrichment analysis showed that puerarin maintained the blood-brain barrier, regulated peptide serine phosphorylation, and had anti-inflammatory effects. KEGG analysis showed that puerarin's anti-inflammatory effects were mainly through VEGF, IL-17, C-type lectin receptor, HIF-1, TNF, and other signaling pathways. Puerarin closely bound PLIN2, PTGS2, VEGFA, and IL6 targets in molecular docking. In vitro, puerarin prevented osteoarthritis. Network pharmacology and bioinformatics explained puerarin's multi-target and multi-pathway treatment of OA, which may be related to ferroptosis, and confirmed its anti-inflammatory effect." @default.
- W4385620149 created "2023-08-08" @default.
- W4385620149 creator A5011335677 @default.
- W4385620149 creator A5019060617 @default.
- W4385620149 creator A5050965845 @default.
- W4385620149 date "2023-08-07" @default.
- W4385620149 modified "2023-09-26" @default.
- W4385620149 title "Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics" @default.
- W4385620149 cites W1558352361 @default.
- W4385620149 cites W1871342107 @default.
- W4385620149 cites W1997183854 @default.
- W4385620149 cites W2033591223 @default.
- W4385620149 cites W2074102239 @default.
- W4385620149 cites W2216912148 @default.
- W4385620149 cites W2792077031 @default.
- W4385620149 cites W2896582829 @default.
- W4385620149 cites W2907579063 @default.
- W4385620149 cites W2912705591 @default.
- W4385620149 cites W2979641493 @default.
- W4385620149 cites W2996774074 @default.
- W4385620149 cites W3016365053 @default.
- W4385620149 cites W3162928950 @default.
- W4385620149 cites W3203626960 @default.
- W4385620149 cites W3210952369 @default.
- W4385620149 cites W4207041766 @default.
- W4385620149 cites W4210666424 @default.
- W4385620149 cites W4287833457 @default.
- W4385620149 cites W4293415363 @default.
- W4385620149 cites W4294845145 @default.
- W4385620149 cites W4308496504 @default.
- W4385620149 cites W72812892 @default.
- W4385620149 doi "https://doi.org/10.1007/s00210-023-02653-9" @default.
- W4385620149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37548663" @default.
- W4385620149 hasPublicationYear "2023" @default.
- W4385620149 type Work @default.
- W4385620149 citedByCount "0" @default.
- W4385620149 crossrefType "journal-article" @default.
- W4385620149 hasAuthorship W4385620149A5011335677 @default.
- W4385620149 hasAuthorship W4385620149A5019060617 @default.
- W4385620149 hasAuthorship W4385620149A5050965845 @default.
- W4385620149 hasBestOaLocation W43856201491 @default.
- W4385620149 hasConcept C104317684 @default.
- W4385620149 hasConcept C142724271 @default.
- W4385620149 hasConcept C150194340 @default.
- W4385620149 hasConcept C152724338 @default.
- W4385620149 hasConcept C162317418 @default.
- W4385620149 hasConcept C203014093 @default.
- W4385620149 hasConcept C204787440 @default.
- W4385620149 hasConcept C2776164576 @default.
- W4385620149 hasConcept C2776914184 @default.
- W4385620149 hasConcept C2778356392 @default.
- W4385620149 hasConcept C55493867 @default.
- W4385620149 hasConcept C60644358 @default.
- W4385620149 hasConcept C71924100 @default.
- W4385620149 hasConcept C86803240 @default.
- W4385620149 hasConcept C98274493 @default.
- W4385620149 hasConceptScore W4385620149C104317684 @default.
- W4385620149 hasConceptScore W4385620149C142724271 @default.
- W4385620149 hasConceptScore W4385620149C150194340 @default.
- W4385620149 hasConceptScore W4385620149C152724338 @default.
- W4385620149 hasConceptScore W4385620149C162317418 @default.
- W4385620149 hasConceptScore W4385620149C203014093 @default.
- W4385620149 hasConceptScore W4385620149C204787440 @default.
- W4385620149 hasConceptScore W4385620149C2776164576 @default.
- W4385620149 hasConceptScore W4385620149C2776914184 @default.
- W4385620149 hasConceptScore W4385620149C2778356392 @default.
- W4385620149 hasConceptScore W4385620149C55493867 @default.
- W4385620149 hasConceptScore W4385620149C60644358 @default.
- W4385620149 hasConceptScore W4385620149C71924100 @default.
- W4385620149 hasConceptScore W4385620149C86803240 @default.
- W4385620149 hasConceptScore W4385620149C98274493 @default.
- W4385620149 hasLocation W43856201491 @default.
- W4385620149 hasLocation W43856201492 @default.
- W4385620149 hasOpenAccess W4385620149 @default.
- W4385620149 hasPrimaryLocation W43856201491 @default.
- W4385620149 hasRelatedWork W1996050826 @default.
- W4385620149 hasRelatedWork W2350596713 @default.
- W4385620149 hasRelatedWork W2413558953 @default.
- W4385620149 hasRelatedWork W2416280168 @default.
- W4385620149 hasRelatedWork W2765289090 @default.
- W4385620149 hasRelatedWork W2782990005 @default.
- W4385620149 hasRelatedWork W2890307065 @default.
- W4385620149 hasRelatedWork W2967392659 @default.
- W4385620149 hasRelatedWork W3094168960 @default.
- W4385620149 hasRelatedWork W4206702427 @default.
- W4385620149 isParatext "false" @default.
- W4385620149 isRetracted "false" @default.
- W4385620149 workType "article" @default.