Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385620730> ?p ?o ?g. }
- W4385620730 abstract "Adoptive cellular therapy using chimeric antigen receptor (CAR) T cells has led to a paradigm shift in the treatment of various hematologic malignancies. However, the broad application of this approach for myeloid malignancies and solid cancers has been limited by the paucity and heterogeneity of target antigen expression, and lack of bona fide tumor-specific antigens that can be targeted without cross-reactivity against normal tissues. This may lead to unwanted on-target off-tumor toxicities that could undermine the desired antitumor effect. Recent advances in synthetic biology and genetic engineering have enabled reprogramming of immune effector cells to enhance their selectivity toward tumors, thus mitigating on-target off-tumor adverse effects. In this review, we outline the current strategies being explored to improve CAR selectivity toward tumor cells with a focus on natural killer (NK) cells, and the progress made in translating these strategies to the clinic." @default.
- W4385620730 created "2023-08-08" @default.
- W4385620730 creator A5007244861 @default.
- W4385620730 creator A5041917404 @default.
- W4385620730 creator A5056568499 @default.
- W4385620730 date "2023-08-07" @default.
- W4385620730 modified "2023-10-17" @default.
- W4385620730 title "Next‐generation chimeric antigen receptors for T‐ and natural killer‐cell therapies against cancer" @default.
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