Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385621926> ?p ?o ?g. }
- W4385621926 abstract "Abstract The interferon-activated tumor innate immunity can be primed by specific double-stranded RNA (dsRNA) sensors upon stimulation. A-to-I RNA editing in the dsRNA regions can have a potential function to regulate interferon-related cancer immunity. A systematical analysis of both the editing enzyme and specific enriched editing region in patients, tissues, and cell lines is performed to reveal the underlying mechanisms. We then validate the preferred editing of dsRNA regions, identify the hyper-editing in severe tumors, and discover the negative effect of editing on cancer immunity. Specifically, RNA editing acts as an inhibitor of PKR - and MDA5 -related interferon pathways through the regulations of miRNAs and RNA-binding proteins and the deactivation of dsRNA sensors. With the alteration of interferons, subsequently, RNA editing represses the infiltration of CD8 and CD4 T cells and reduces the sensitivities of cancer drugs, such as cisplatin. These analyses on A-to-I RNA editing can improve the knowledge of tumorigenesis, immunology, and cancer-targeted immunotherapy. Highlights The preferred dsRNA region for RNA editing is validated. Upregulation of RNA editing in severe tumors is discovered. RNA editing inhibits PKR- and MDA5-related cancer immunity. RNA editing represses the infiltration of CD8 and CD4 T cells. RNA editing reduces the sensitivities of cancer drugs." @default.
- W4385621926 created "2023-08-08" @default.
- W4385621926 creator A5007948673 @default.
- W4385621926 creator A5008326829 @default.
- W4385621926 creator A5014102611 @default.
- W4385621926 creator A5030202287 @default.
- W4385621926 creator A5034751080 @default.
- W4385621926 creator A5044062128 @default.
- W4385621926 creator A5048858126 @default.
- W4385621926 creator A5069380051 @default.
- W4385621926 date "2023-08-07" @default.
- W4385621926 modified "2023-09-24" @default.
- W4385621926 title "The roles of RNA editing in cancer immunity through interacting with interferon" @default.
- W4385621926 cites W1977391294 @default.
- W4385621926 cites W1984068087 @default.
- W4385621926 cites W1997535872 @default.
- W4385621926 cites W2016749309 @default.
- W4385621926 cites W2050077513 @default.
- W4385621926 cites W2052685738 @default.
- W4385621926 cites W2059285632 @default.
- W4385621926 cites W2075294566 @default.
- W4385621926 cites W2117977572 @default.
- W4385621926 cites W2156891661 @default.
- W4385621926 cites W2214074259 @default.
- W4385621926 cites W2345356016 @default.
- W4385621926 cites W2587454003 @default.
- W4385621926 cites W2587898769 @default.
- W4385621926 cites W2788142646 @default.
- W4385621926 cites W2791830191 @default.
- W4385621926 cites W2803902474 @default.
- W4385621926 cites W2806461678 @default.
- W4385621926 cites W2883220169 @default.
- W4385621926 cites W2890697585 @default.
- W4385621926 cites W2902184576 @default.
- W4385621926 cites W2903746377 @default.
- W4385621926 cites W2904139947 @default.
- W4385621926 cites W2912593436 @default.
- W4385621926 cites W2913056544 @default.
- W4385621926 cites W2913776187 @default.
- W4385621926 cites W2952729952 @default.
- W4385621926 cites W2960943033 @default.
- W4385621926 cites W2968188498 @default.
- W4385621926 cites W2972096813 @default.
- W4385621926 cites W2977255036 @default.
- W4385621926 cites W3011498764 @default.
- W4385621926 cites W3027045752 @default.
- W4385621926 cites W3028523516 @default.
- W4385621926 cites W3093713985 @default.
- W4385621926 cites W3107837609 @default.
- W4385621926 cites W3118344808 @default.
- W4385621926 cites W3151427897 @default.
- W4385621926 cites W3212486954 @default.
- W4385621926 cites W3214913540 @default.
- W4385621926 cites W3216169886 @default.
- W4385621926 cites W4283256993 @default.
- W4385621926 cites W4289745435 @default.
- W4385621926 cites W4290725198 @default.
- W4385621926 cites W4303575274 @default.
- W4385621926 cites W4309107106 @default.
- W4385621926 cites W4318015149 @default.
- W4385621926 cites W4319069456 @default.
- W4385621926 cites W4319597894 @default.
- W4385621926 cites W4321116140 @default.
- W4385621926 cites W4366091418 @default.
- W4385621926 doi "https://doi.org/10.1101/2023.08.06.552142" @default.
- W4385621926 hasPublicationYear "2023" @default.
- W4385621926 type Work @default.
- W4385621926 citedByCount "0" @default.
- W4385621926 crossrefType "posted-content" @default.
- W4385621926 hasAuthorship W4385621926A5007948673 @default.
- W4385621926 hasAuthorship W4385621926A5008326829 @default.
- W4385621926 hasAuthorship W4385621926A5014102611 @default.
- W4385621926 hasAuthorship W4385621926A5030202287 @default.
- W4385621926 hasAuthorship W4385621926A5034751080 @default.
- W4385621926 hasAuthorship W4385621926A5044062128 @default.
- W4385621926 hasAuthorship W4385621926A5048858126 @default.
- W4385621926 hasAuthorship W4385621926A5069380051 @default.
- W4385621926 hasBestOaLocation W43856219261 @default.
- W4385621926 hasConcept C104317684 @default.
- W4385621926 hasConcept C121608353 @default.
- W4385621926 hasConcept C134474686 @default.
- W4385621926 hasConcept C145059251 @default.
- W4385621926 hasConcept C153911025 @default.
- W4385621926 hasConcept C161238802 @default.
- W4385621926 hasConcept C166703698 @default.
- W4385621926 hasConcept C21786251 @default.
- W4385621926 hasConcept C2191507 @default.
- W4385621926 hasConcept C2776178377 @default.
- W4385621926 hasConcept C29537977 @default.
- W4385621926 hasConcept C502942594 @default.
- W4385621926 hasConcept C54355233 @default.
- W4385621926 hasConcept C67705224 @default.
- W4385621926 hasConcept C70721500 @default.
- W4385621926 hasConcept C82495950 @default.
- W4385621926 hasConcept C86803240 @default.
- W4385621926 hasConceptScore W4385621926C104317684 @default.
- W4385621926 hasConceptScore W4385621926C121608353 @default.
- W4385621926 hasConceptScore W4385621926C134474686 @default.
- W4385621926 hasConceptScore W4385621926C145059251 @default.
- W4385621926 hasConceptScore W4385621926C153911025 @default.