FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385622105> ?p ?o ?g. }

• W4385622105 endingPage "38380" @default.
• W4385622105 startingPage "38367" @default.
• W4385622105 abstract "Metal-organic frameworks (MOFs) have found increasing applications in the biomedical field due to their unique properties and high modularity. Although the limited stability of MOFs in biological environments is increasingly recognized, analytical techniques have not yet been harnessed to their full potential to assess the biological fate of MOFs. Here, we investigate the environment-dependent biochemical transformations of widely researched nanosized MOFs (nMOFs) under conditions relevant to their medical application. We assess the chemical stability of antimicrobial zinc-based drug delivery nMOFs (Zn-ZIF-8 and Zn-ZIF-8:Ce) and radio-enhancer candidate nMOFs (Hf-DBA, Ti-MIL-125, and TiZr-PCN-415) containing biologically nonessential group IV metal ions. We reveal that even a moderate decrease in pH to values encountered in lysosomes (pH 4.5-5) leads to significant dissolution of ZIF-8 and partial dissolution of Ti-MIL-125, whereas no substantial dissolution was observed for TiZr-PCN-415 and Hf-DBA nMOFs. Exposure to phosphate-rich buffers led to phosphate incorporation in all nMOFs, resulting in amorphization and morphological changes. Interestingly, long-term cell culture studies revealed that nMOF (bio)transformations of, e.g., Ti-MIL-125 were cellular compartment-dependent and that the phosphate content in the nMOF varied significantly between nMOFs localized in lysosomes and those in the cytoplasm. These results illustrate the delicate nature and environment-dependent properties of nMOFs across all stages of their life cycle, including storage, formulation, and application, and the need for in-depth analyses of biotransformations for an improved understanding of structure-function relationships. The findings encourage the considerate choice of suspension buffers for MOFs because these media may lead to significant material alterations prior to application." @default.
• W4385622105 created "2023-08-08" @default.
• W4385622105 creator A5007129249 @default.
• W4385622105 creator A5018301737 @default.
• W4385622105 creator A5036996577 @default.
• W4385622105 creator A5073438593 @default.
• W4385622105 creator A5089699712 @default.
• W4385622105 creator A5092834780 @default.
• W4385622105 date "2023-08-07" @default.
• W4385622105 modified "2023-10-15" @default.
• W4385622105 title "Nanoanalytical Insights into the Stability, Intracellular Fate, and Biotransformation of Metal–Organic Frameworks" @default.
• W4385622105 cites W1967985930 @default.
• W4385622105 cites W1996697333 @default.
• W4385622105 cites W2001197606 @default.
• W4385622105 cites W2038440906 @default.
• W4385622105 cites W2055574464 @default.
• W4385622105 cites W2066991705 @default.
• W4385622105 cites W2067438336 @default.
• W4385622105 cites W2084063536 @default.
• W4385622105 cites W2090527133 @default.
• W4385622105 cites W2098032582 @default.
• W4385622105 cites W2101927545 @default.
• W4385622105 cites W2103732964 @default.
• W4385622105 cites W2103818266 @default.
• W4385622105 cites W2107991409 @default.
• W4385622105 cites W2109636815 @default.
• W4385622105 cites W2193269929 @default.
• W4385622105 cites W2330408069 @default.
• W4385622105 cites W2338361667 @default.
• W4385622105 cites W2514597002 @default.
• W4385622105 cites W2569909810 @default.
• W4385622105 cites W2586857732 @default.
• W4385622105 cites W2602228571 @default.
• W4385622105 cites W2608941817 @default.
• W4385622105 cites W2621780300 @default.
• W4385622105 cites W2755460304 @default.
• W4385622105 cites W2763763612 @default.
• W4385622105 cites W2769861469 @default.
• W4385622105 cites W2770232639 @default.
• W4385622105 cites W2772007278 @default.
• W4385622105 cites W2783277173 @default.
• W4385622105 cites W2793242423 @default.
• W4385622105 cites W2793373651 @default.
• W4385622105 cites W2794088502 @default.
• W4385622105 cites W2808570189 @default.
• W4385622105 cites W2887777879 @default.
• W4385622105 cites W2912183578 @default.
• W4385622105 cites W2940059027 @default.
• W4385622105 cites W2940955531 @default.
• W4385622105 cites W2948875545 @default.
• W4385622105 cites W2950825820 @default.
• W4385622105 cites W2969220851 @default.
• W4385622105 cites W2977459771 @default.
• W4385622105 cites W2996345353 @default.
• W4385622105 cites W3011557612 @default.
• W4385622105 cites W3017165857 @default.
• W4385622105 cites W3092514558 @default.
• W4385622105 cites W3176552993 @default.
• W4385622105 cites W4226081506 @default.
• W4385622105 cites W4293860392 @default.
• W4385622105 cites W4304115582 @default.
• W4385622105 cites W4376503803 @default.
• W4385622105 doi "https://doi.org/10.1021/acsami.3c08818" @default.
• W4385622105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37549199" @default.
• W4385622105 hasPublicationYear "2023" @default.
• W4385622105 type Work @default.
• W4385622105 citedByCount "0" @default.
• W4385622105 crossrefType "journal-article" @default.
• W4385622105 hasAuthorship W4385622105A5007129249 @default.
• W4385622105 hasAuthorship W4385622105A5018301737 @default.
• W4385622105 hasAuthorship W4385622105A5036996577 @default.
• W4385622105 hasAuthorship W4385622105A5073438593 @default.
• W4385622105 hasAuthorship W4385622105A5089699712 @default.
• W4385622105 hasAuthorship W4385622105A5092834780 @default.
• W4385622105 hasConcept C12554922 @default.
• W4385622105 hasConcept C150394285 @default.
• W4385622105 hasConcept C171250308 @default.
• W4385622105 hasConcept C178790620 @default.
• W4385622105 hasConcept C179366358 @default.
• W4385622105 hasConcept C181199279 @default.
• W4385622105 hasConcept C185592680 @default.
• W4385622105 hasConcept C192562407 @default.
• W4385622105 hasConcept C2779820397 @default.
• W4385622105 hasConcept C27881333 @default.
• W4385622105 hasConcept C55493867 @default.
• W4385622105 hasConcept C86803240 @default.
• W4385622105 hasConcept C88380143 @default.
• W4385622105 hasConceptScore W4385622105C12554922 @default.
• W4385622105 hasConceptScore W4385622105C150394285 @default.
• W4385622105 hasConceptScore W4385622105C171250308 @default.
• W4385622105 hasConceptScore W4385622105C178790620 @default.
• W4385622105 hasConceptScore W4385622105C179366358 @default.
• W4385622105 hasConceptScore W4385622105C181199279 @default.
• W4385622105 hasConceptScore W4385622105C185592680 @default.
• W4385622105 hasConceptScore W4385622105C192562407 @default.
• W4385622105 hasConceptScore W4385622105C2779820397 @default.
• W4385622105 hasConceptScore W4385622105C27881333 @default.
• W4385622105 hasConceptScore W4385622105C55493867 @default.

• next