FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385622997> ?p ?o ?g. }

• W4385622997 abstract "Abstract Myeloproliferative neoplasms are stem cell-driven cancers associated with a large burden of morbidity and mortality. The majority of patients present with early-stage disease, but a substantial proportion progress to myelofibrosis and/or secondary leukemia, advanced cancers with a poor prognosis and high symptom burden. Currently, it remains difficult to predict progression, and we lack therapies that reliably prevent or reverse fibrosis development. A major bottleneck to the discovery of disease-modifying therapies has been an incomplete understanding of the interplay between perturbed cellular and molecular states. Several cell types have individually been implicated, but a comprehensive analysis of myelofibrotic bone marrow is lacking. We therefore mapped the crosstalk between bone marrow cell types in myelofibrotic bone marrow. We found that inflammation and fibrosis are orchestrated by a ‘quartet’ of immune and stromal cell lineages – with basophils and mast cells creating a TNF signaling hub, communicating with megakaryocytes, mesenchymal stromal cells and pro-inflammatory fibroblasts. We identified the ý-galactoside binding protein galectin 1 as a striking biomarker of progression to myelofibrosis and poor survival in multiple patient cohorts, and as a promising therapeutic target, with reduced myeloproliferation and fibrosis in vitro and in vivo and improved survival following galectin 1 inhibition. In human bone marrow organoids, TNF increased galectin 1 expression, suggesting a feedback loop wherein the pro-inflammatory MPN clone creates a self-reinforcing niche, fueling progression to advanced disease. This study provides a valuable resource for studying hematopoietic cell-niche interactions, with broad relevance for cancer-associated inflammation and disorders of tissue fibrosis." @default.
• W4385622997 created "2023-08-08" @default.
• W4385622997 creator A5003941928 @default.
• W4385622997 creator A5005500986 @default.
• W4385622997 creator A5007366470 @default.
• W4385622997 creator A5012308763 @default.
• W4385622997 creator A5012343852 @default.
• W4385622997 creator A5012366273 @default.
• W4385622997 creator A5013760778 @default.
• W4385622997 creator A5015953746 @default.
• W4385622997 creator A5016954236 @default.
• W4385622997 creator A5017057703 @default.
• W4385622997 creator A5023326852 @default.
• W4385622997 creator A5024226262 @default.
• W4385622997 creator A5024298356 @default.
• W4385622997 creator A5025530223 @default.
• W4385622997 creator A5025797543 @default.
• W4385622997 creator A5026173455 @default.
• W4385622997 creator A5029168436 @default.
• W4385622997 creator A5031551301 @default.
• W4385622997 creator A5031640494 @default.
• W4385622997 creator A5032426555 @default.
• W4385622997 creator A5032950249 @default.
• W4385622997 creator A5035701043 @default.
• W4385622997 creator A5035712428 @default.
• W4385622997 creator A5037405971 @default.
• W4385622997 creator A5042275051 @default.
• W4385622997 creator A5049306537 @default.
• W4385622997 creator A5053302921 @default.
• W4385622997 creator A5068251955 @default.
• W4385622997 creator A5071559896 @default.
• W4385622997 creator A5072002953 @default.
• W4385622997 creator A5086643288 @default.
• W4385622997 creator A5088580471 @default.
• W4385622997 date "2023-08-07" @default.
• W4385622997 modified "2023-10-03" @default.
• W4385622997 title "A pro-inflammatory stem cell niche drives myelofibrosis through a targetable galectin 1 axis" @default.
• W4385622997 cites W124485265 @default.
• W4385622997 cites W1255676896 @default.
• W4385622997 cites W1526907282 @default.
• W4385622997 cites W1979438759 @default.
• W4385622997 cites W1986581033 @default.
• W4385622997 cites W1994634559 @default.
• W4385622997 cites W1995981641 @default.
• W4385622997 cites W1996631625 @default.
• W4385622997 cites W1997430966 @default.
• W4385622997 cites W2001979983 @default.
• W4385622997 cites W2008657060 @default.
• W4385622997 cites W2045032252 @default.
• W4385622997 cites W2061434349 @default.
• W4385622997 cites W2080432978 @default.
• W4385622997 cites W2089676937 @default.
• W4385622997 cites W2105683352 @default.
• W4385622997 cites W2116878961 @default.
• W4385622997 cites W2130410032 @default.
• W4385622997 cites W2131495509 @default.
• W4385622997 cites W2132162500 @default.
• W4385622997 cites W2133059825 @default.
• W4385622997 cites W2134443544 @default.
• W4385622997 cites W2164450795 @default.
• W4385622997 cites W2195061194 @default.
• W4385622997 cites W2254008564 @default.
• W4385622997 cites W2583102591 @default.
• W4385622997 cites W2592929672 @default.
• W4385622997 cites W2607334934 @default.
• W4385622997 cites W2607959672 @default.
• W4385622997 cites W2613365198 @default.
• W4385622997 cites W2768112975 @default.
• W4385622997 cites W2780126758 @default.
• W4385622997 cites W2793344857 @default.
• W4385622997 cites W2810569452 @default.
• W4385622997 cites W2912561801 @default.
• W4385622997 cites W2936664461 @default.
• W4385622997 cites W2944564829 @default.
• W4385622997 cites W2946721812 @default.
• W4385622997 cites W2953923156 @default.
• W4385622997 cites W2965641704 @default.
• W4385622997 cites W2995703197 @default.
• W4385622997 cites W3002770500 @default.
• W4385622997 cites W3022009389 @default.
• W4385622997 cites W3031385466 @default.
• W4385622997 cites W3036264672 @default.
• W4385622997 cites W3044964811 @default.
• W4385622997 cites W3049244854 @default.
• W4385622997 cites W3090568079 @default.
• W4385622997 cites W3112914139 @default.
• W4385622997 cites W3119685153 @default.
• W4385622997 cites W3125727679 @default.
• W4385622997 cites W3132068389 @default.
• W4385622997 cites W3132661792 @default.
• W4385622997 cites W3152911680 @default.
• W4385622997 cites W3163348136 @default.
• W4385622997 cites W3201860900 @default.
• W4385622997 cites W3202412941 @default.
• W4385622997 cites W3203496375 @default.
• W4385622997 cites W3203654614 @default.
• W4385622997 cites W3206984067 @default.
• W4385622997 cites W3210702954 @default.
• W4385622997 cites W4206959743 @default.
• W4385622997 cites W4206994398 @default.

• next