Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385628513> ?p ?o ?g. }
- W4385628513 endingPage "109371" @default.
- W4385628513 startingPage "109371" @default.
- W4385628513 abstract "ObjectiveWe aimed to (i) compare the clinical, neuropsychological, and neuroimaging characteristics of unprovoked late-onset epilepsy (LOE) patients with cognitive symptoms against probable Alzheimer’s disease (AD) patients; (ii) clarify how neurodegeneration and other processes could be implicated in the cognitive symptoms of unprovoked LOE patients; and (iii) characterize the longitudinal trajectory of unprovoked LOE patients with cognitive symptoms.MethodsTwenty-six unprovoked LOE patients with cognitive symptoms and 26 probable AD were retrospectively recruited from epilepsy and memory clinics at a single tertiary referral center. The patients underwent comprehensive clinical, neuropsychological, and 18Fluorodeoxyglucose PET-CT assessments. All LOE patients had clinical follow-up and a subset of 17 patients had repeat neuropsychological assessments.ResultsAt baseline, 18% of LOE patients with cognitive symptoms had dementia-range cognitive impairment and one received a diagnosis of probable AD. Compared with the probable AD group, the LOE group did not perform significantly better in global measures of cognition (total ACE-III), neuropsychological tests for fluency, working memory, language, attention, or executive function, but performed better in naming, memory, and visuospatial ability. The commonest patterns of cognitive impairment in the LOE group were frontal and left temporal, whereas all AD patients exhibited parietotemporal patterns. The AD group had more 18Fluorodeoxyglucose PET-CT hypometabolism in the parietal and occipital, but not the temporal and frontal lobes. During the 3.0 ± 3.2 years follow-up, improved seizure frequency in the LOE group covaried with improved total ACE-III score, there was no further conversion to probable AD and no group-level cognitive decline.ConclusionUnprovoked LOE patients with cognitive symptoms had varying severities of cognitive impairment, and different patterns of cognitive and imaging abnormalities compared with AD patients. They were rarely diagnosed with probable AD at presentation or follow-up. Cognitive outcome in LOE may be related to seizure control. Cerebral small vessel disease may play a role in LOE-associated cognitive impairment." @default.
- W4385628513 created "2023-08-08" @default.
- W4385628513 creator A5016183418 @default.
- W4385628513 creator A5026291544 @default.
- W4385628513 creator A5035061427 @default.
- W4385628513 creator A5053187476 @default.
- W4385628513 creator A5055081506 @default.
- W4385628513 creator A5070438668 @default.
- W4385628513 creator A5082979981 @default.
- W4385628513 date "2023-09-01" @default.
- W4385628513 modified "2023-10-16" @default.
- W4385628513 title "Late-onset epilepsy with cognitive symptoms: Comparison of cognitive and imaging profiles with probable Alzheimer’s disease" @default.
- W4385628513 cites W1635560988 @default.
- W4385628513 cites W1824002464 @default.
- W4385628513 cites W1859821439 @default.
- W4385628513 cites W1970910654 @default.
- W4385628513 cites W1978437325 @default.
- W4385628513 cites W1999887188 @default.
- W4385628513 cites W2000555003 @default.
- W4385628513 cites W2010003817 @default.
- W4385628513 cites W2019200696 @default.
- W4385628513 cites W2021095289 @default.
- W4385628513 cites W2056134818 @default.
- W4385628513 cites W2061953875 @default.
- W4385628513 cites W2065087340 @default.
- W4385628513 cites W2071252381 @default.
- W4385628513 cites W2091931051 @default.
- W4385628513 cites W2093762179 @default.
- W4385628513 cites W2103101417 @default.
- W4385628513 cites W2115017507 @default.
- W4385628513 cites W2127023333 @default.
- W4385628513 cites W2136734328 @default.
- W4385628513 cites W2147966028 @default.
- W4385628513 cites W2254381425 @default.
- W4385628513 cites W2495018713 @default.
- W4385628513 cites W2580008281 @default.
- W4385628513 cites W2793579479 @default.
- W4385628513 cites W2884721824 @default.
- W4385628513 cites W2891376500 @default.
- W4385628513 cites W2987311298 @default.
- W4385628513 cites W3007799486 @default.
- W4385628513 cites W3009868680 @default.
- W4385628513 cites W3093973623 @default.
- W4385628513 cites W3094167344 @default.
- W4385628513 cites W3094443046 @default.
- W4385628513 cites W3109815106 @default.
- W4385628513 cites W4240214838 @default.
- W4385628513 doi "https://doi.org/10.1016/j.yebeh.2023.109371" @default.
- W4385628513 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37556966" @default.
- W4385628513 hasPublicationYear "2023" @default.
- W4385628513 type Work @default.
- W4385628513 citedByCount "0" @default.
- W4385628513 crossrefType "journal-article" @default.
- W4385628513 hasAuthorship W4385628513A5016183418 @default.
- W4385628513 hasAuthorship W4385628513A5026291544 @default.
- W4385628513 hasAuthorship W4385628513A5035061427 @default.
- W4385628513 hasAuthorship W4385628513A5053187476 @default.
- W4385628513 hasAuthorship W4385628513A5055081506 @default.
- W4385628513 hasAuthorship W4385628513A5070438668 @default.
- W4385628513 hasAuthorship W4385628513A5082979981 @default.
- W4385628513 hasBestOaLocation W43856285131 @default.
- W4385628513 hasConcept C118552586 @default.
- W4385628513 hasConcept C126322002 @default.
- W4385628513 hasConcept C14216870 @default.
- W4385628513 hasConcept C15744967 @default.
- W4385628513 hasConcept C169900460 @default.
- W4385628513 hasConcept C187212893 @default.
- W4385628513 hasConcept C2775968953 @default.
- W4385628513 hasConcept C2776656118 @default.
- W4385628513 hasConcept C2778186239 @default.
- W4385628513 hasConcept C2779134260 @default.
- W4385628513 hasConcept C2779483572 @default.
- W4385628513 hasConcept C2780046773 @default.
- W4385628513 hasConcept C2984863031 @default.
- W4385628513 hasConcept C502032728 @default.
- W4385628513 hasConcept C536788834 @default.
- W4385628513 hasConcept C548259974 @default.
- W4385628513 hasConcept C71924100 @default.
- W4385628513 hasConcept C97530452 @default.
- W4385628513 hasConceptScore W4385628513C118552586 @default.
- W4385628513 hasConceptScore W4385628513C126322002 @default.
- W4385628513 hasConceptScore W4385628513C14216870 @default.
- W4385628513 hasConceptScore W4385628513C15744967 @default.
- W4385628513 hasConceptScore W4385628513C169900460 @default.
- W4385628513 hasConceptScore W4385628513C187212893 @default.
- W4385628513 hasConceptScore W4385628513C2775968953 @default.
- W4385628513 hasConceptScore W4385628513C2776656118 @default.
- W4385628513 hasConceptScore W4385628513C2778186239 @default.
- W4385628513 hasConceptScore W4385628513C2779134260 @default.
- W4385628513 hasConceptScore W4385628513C2779483572 @default.
- W4385628513 hasConceptScore W4385628513C2780046773 @default.
- W4385628513 hasConceptScore W4385628513C2984863031 @default.
- W4385628513 hasConceptScore W4385628513C502032728 @default.
- W4385628513 hasConceptScore W4385628513C536788834 @default.
- W4385628513 hasConceptScore W4385628513C548259974 @default.
- W4385628513 hasConceptScore W4385628513C71924100 @default.
- W4385628513 hasConceptScore W4385628513C97530452 @default.
- W4385628513 hasLocation W43856285131 @default.