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• W4385628522 endingPage "115296" @default.
• W4385628522 startingPage "115296" @default.
• W4385628522 abstract "Glioblastoma is a type of intracranial malignancy. Shikonin, a Chinese traditional medicine, has been shown to have anti-tumor efficacy toward human glioblastoma cells in vitro. However, shikonin cannot easily cross the blood–brain barrier. To address this issue, we evaluated the anti-tumor effects of direct intracranial infusion of shikonin in in vivo orthotopic syngeneic murine glioblastoma models using C57BL/6 mice. The cytotoxic effects of shikonin against murine glioblastoma cells, SB28 and CT-2A, were reported resistance to temozolomide, were evaluated using an allophycocyanin-conjugated annexin V and propidium iodide assay with flow cytometry. Impedance-based real-time cell analysis (RTCA) was used to analyze the inhibitory effects of shikonin on growth and proliferation. To evaluate the anti-tumor activity of shikonin in vivo, we used orthotopic syngeneic murine glioblastoma models with SB28 and CT-2A cells. In flow cytometry-based cytotoxic assays, shikonin induced apoptosis. RTCA indicated that shikonin decreased the cell index of murine glioblastoma cells, SB28 and CT-2A, in a dose-dependent manner (p < 0.0001 for both cell lines), while temozolomide did not (p = 0.91 and 0.82, respectively). In murine glioblastoma models, SB28 and CT-2A, direct intracranial infusion of shikonin, as a local chemotherapy, improved the overall survival of mice in a dose-dependent manner compared with control groups (p < 0.0001 and p = 0.02, respectively). While temozolomide did not (p = 0.48 and 0.52, respectively). The direct intracranial infusion of shikonin has potential as a local therapy for patients with glioblastoma." @default.
• W4385628522 created "2023-08-08" @default.
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• W4385628522 date "2023-10-01" @default.
• W4385628522 modified "2023-10-09" @default.
• W4385628522 title "Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance" @default.
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• W4385628522 doi "https://doi.org/10.1016/j.biopha.2023.115296" @default.
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• W4385628522 hasPublicationYear "2023" @default.
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