Matches in SemOpenAlex for { <https://semopenalex.org/work/W43856293> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W43856293 startingPage "149" @default.
- W43856293 abstract "BACKGROUND AND OBJECTIVES Pain is necessary for survival but chronic pain is disabling and causes significant health and economic problems. Chronic stump pain (pain localized in the stump for >3 months) after amputation is a significant problem among amputees (5-10%). The mechanism of this phenomenon is not very clear yet. In this study we attempted to better understand the role of peripheral and central mechanisms in this condition. METHODS 12 patients with established lower limb post-amputation stump pain were given lumbar epidural diamorhpine 5 mg in 20 ml normal saline (NS) and levobupivacaine 0.5% (20 ml) 1 week apart. Baseline pain was recorded and then analgesic and side effects as well as their onset and duration were also assessed. RESULTS Epidural diamorphine was found to relieve the pain of all patients. Its onset was relatively rapid being started within 5-9 min (median = 5.5) by a smooth sensation of warmth involving the lower trunk and legs. Analgesia was complete in 30 min and had a median duration of 20.5 h. Pruritus in 6 patients was the only side effect due to epidural diamorphine. Epidural levobupivacaine, on the other hand, usually relieved the discomfort but failed to do so in 3 patients only despite adequate neural blockade. Its onset of action was slower (10-20 min, median = 11) and duration of effect (median = 12 h) was also shorter than diamorphine. The effects of levobupivacaine were inferior to diamorphine due to the associated motor and sensory paralyses as well as absence of euphoria. Epidural diamorphine provided profound analgesia with normalization of stump sensations and euphoria, probably due to absorption into the spinal cord causing segmental action. CONCLUSION While peripheral mechanisms played a role, central mechanisms involving the spinal cord were more important in the modulation of established stump pain in the evaluated patients." @default.
- W43856293 created "2016-06-24" @default.
- W43856293 creator A5074915241 @default.
- W43856293 date "2005-02-01" @default.
- W43856293 modified "2023-09-24" @default.
- W43856293 title "The analgesic effects of epidural diamorphine and levobupivacaine on established lower limb post-amputation stump pain--a comparative study." @default.
- W43856293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15830770" @default.
- W43856293 hasPublicationYear "2005" @default.
- W43856293 type Work @default.
- W43856293 sameAs 43856293 @default.
- W43856293 citedByCount "1" @default.
- W43856293 countsByYear W438562932012 @default.
- W43856293 crossrefType "journal-article" @default.
- W43856293 hasAuthorship W43856293A5074915241 @default.
- W43856293 hasConcept C141071460 @default.
- W43856293 hasConcept C1862650 @default.
- W43856293 hasConcept C2776204877 @default.
- W43856293 hasConcept C2776572635 @default.
- W43856293 hasConcept C2777389121 @default.
- W43856293 hasConcept C2777397205 @default.
- W43856293 hasConcept C2780820201 @default.
- W43856293 hasConcept C2781118164 @default.
- W43856293 hasConcept C42219234 @default.
- W43856293 hasConcept C44575665 @default.
- W43856293 hasConcept C71924100 @default.
- W43856293 hasConceptScore W43856293C141071460 @default.
- W43856293 hasConceptScore W43856293C1862650 @default.
- W43856293 hasConceptScore W43856293C2776204877 @default.
- W43856293 hasConceptScore W43856293C2776572635 @default.
- W43856293 hasConceptScore W43856293C2777389121 @default.
- W43856293 hasConceptScore W43856293C2777397205 @default.
- W43856293 hasConceptScore W43856293C2780820201 @default.
- W43856293 hasConceptScore W43856293C2781118164 @default.
- W43856293 hasConceptScore W43856293C42219234 @default.
- W43856293 hasConceptScore W43856293C44575665 @default.
- W43856293 hasConceptScore W43856293C71924100 @default.
- W43856293 hasIssue "1" @default.
- W43856293 hasLocation W438562931 @default.
- W43856293 hasLocation W438562932 @default.
- W43856293 hasOpenAccess W43856293 @default.
- W43856293 hasPrimaryLocation W438562931 @default.
- W43856293 hasRelatedWork W179292896 @default.
- W43856293 hasRelatedWork W1995208552 @default.
- W43856293 hasRelatedWork W2003632088 @default.
- W43856293 hasRelatedWork W2027798373 @default.
- W43856293 hasRelatedWork W2057182247 @default.
- W43856293 hasRelatedWork W2079028515 @default.
- W43856293 hasRelatedWork W2090053993 @default.
- W43856293 hasRelatedWork W2092709761 @default.
- W43856293 hasRelatedWork W2155133611 @default.
- W43856293 hasRelatedWork W2278739696 @default.
- W43856293 hasRelatedWork W2334281707 @default.
- W43856293 hasRelatedWork W2403052064 @default.
- W43856293 hasRelatedWork W2408671993 @default.
- W43856293 hasRelatedWork W2416012377 @default.
- W43856293 hasRelatedWork W2469094202 @default.
- W43856293 hasRelatedWork W2761861590 @default.
- W43856293 hasRelatedWork W2970211579 @default.
- W43856293 hasRelatedWork W2970700496 @default.
- W43856293 hasRelatedWork W2988521573 @default.
- W43856293 hasRelatedWork W3165346373 @default.
- W43856293 hasVolume "18" @default.
- W43856293 isParatext "false" @default.
- W43856293 isRetracted "false" @default.
- W43856293 magId "43856293" @default.
- W43856293 workType "article" @default.