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- W4385630988 abstract "Alcohol is a widely consumed substance, with 67% of the adult population in the United States having consumed alcohol in the last year and 23% of these adults having engaged in binge drinking within the last month ( 1 Substance Abuse and Mental Health Services AdministrationCenter for Behavioral Health Statistics and Quality (2021): 2021 National Survey on Drug Use and Health. Alcohol use in past year: Among people aged 12 or older; by age group and demographic characteristics, numbers in thousands, 2021 (Table 2.26A and Table 2.28A). U.S. Department of Health and Human Services, Rockville, MD2021 Google Scholar ). Despite its prevalence, the transition from casual alcohol use to the development of alcohol use disorder (AUD) remains a complex challenge to understand. A multitude of factors, including heavy alcohol intake, genetic predisposition, and environmental stressors, converge to contribute to the pathogenesis of AUD. Unraveling the complex interplay of these factors in human subjects poses inherent difficulties; thus, preclinical models have played a crucial role in elucidating the neural mechanisms and brain regions involved in different stages of alcohol use. SEE CORRESPONDING ARTICLE ON PAGE 393 SEE CORRESPONDING ARTICLE ON PAGE 393 Alcohol Dependence Modifies Brain Networks Activated During Withdrawal and Reaccess: A c-Fos–Based Analysis in MiceBiological PsychiatryVol. 94Issue 5PreviewHigh-level alcohol consumption causes neuroplastic changes in the brain that promote pathological drinking behavior. Some of these changes have been characterized in defined brain circuits and cell types, but unbiased approaches are needed to explore broader patterns of adaptations. Full-Text PDF" @default.
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- W4385630988 date "2023-09-01" @default.
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- W4385630988 title "Unveiling New Brain Circuits and Network Activity in Alcohol Use Disorder: Insights From Innovative Technologies" @default.
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- W4385630988 doi "https://doi.org/10.1016/j.biopsych.2023.06.020" @default.
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