FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385632493> ?p ?o ?g. }

• W4385632493 endingPage "3344" @default.
• W4385632493 startingPage "3331" @default.
• W4385632493 abstract "Chronic kidney disease (CKD) progression is complex. There are not standardized methods for predicting the prognosis of CKD. Nicotinamide N-methyltransferase (NNMT) has been shown to be associated with renal fibrosis. This study aimed to validate NNMT as a prognostic biomarker of progressive CKD.We explored the relationship between NNMT expression and CKD-related outcome variables using the NephroseqV5 and GEO databases. Additionally, a validation set of 37 CKD patients was enrolled to measure the correlation between NNMT expression levels and CKD outcomes. Furthermore, single-cell RNA sequencing data and the Human Protein Atlas were reanalyzed to investigate the expression specificity of NNMT in the kidney. Finally, to detect the status of NNMT expression with tubular fibrosis in vivo, we constructed a unilateral ureteral obstruction (UUO) mouse treated with an NNMT inhibitor.Analyzing the datasets showed that NNMT was expressed mainly in proximal tubule compartments. And patients with high NNMT expression levels had a significantly lower overall survival rate compared to those with low NNMT expression levels (P = 0.013). NNMT was independent of prognosis factors in the multivariate Cox regression model, and the AUCs for CKD progression at 1, 3, and 5 years were 0.849, 0.775, and 0.877, respectively. Pathway enrichment analysis indicated that NNMT regulates the biological processes of tubulointerstitial fibrosis (TIF). In the validation group, NNMT levels were significantly higher in the CKD group combined with interstitial fibrosis. In vivo, NNMT was a high expression in the UUO group, peaking at postoperative day 21. Treatment with an NNMT inhibitor improved renal tubular interstitial fibrosis, and expression levels of FN, α-SMA, VIM, and TGF-β1 were decreased compared with UUO (P < 0.05).NNMT was expressed mainly in tubular renal compartments, and associated with CKD prognosis. It holds potential as a diagnostic biomarker for tubular fibrosis in CKD." @default.
• W4385632493 created "2023-08-08" @default.
• W4385632493 creator A5023700139 @default.
• W4385632493 creator A5038274859 @default.
• W4385632493 creator A5046728023 @default.
• W4385632493 creator A5050489000 @default.
• W4385632493 creator A5058152911 @default.
• W4385632493 creator A5062982554 @default.
• W4385632493 creator A5064149545 @default.
• W4385632493 creator A5072795022 @default.
• W4385632493 creator A5073808661 @default.
• W4385632493 creator A5079090183 @default.
• W4385632493 creator A5083089425 @default.
• W4385632493 creator A5087845425 @default.
• W4385632493 date "2023-08-01" @default.
• W4385632493 modified "2023-10-16" @default.
• W4385632493 title "Nicotinamide N-Methyl Transferase as a Predictive Marker of Tubular Fibrosis in CKD" @default.
• W4385632493 cites W1806116087 @default.
• W4385632493 cites W1991601678 @default.
• W4385632493 cites W2031017520 @default.
• W4385632493 cites W2033031854 @default.
• W4385632493 cites W2033363973 @default.
• W4385632493 cites W2062481845 @default.
• W4385632493 cites W2101163066 @default.
• W4385632493 cites W2113773963 @default.
• W4385632493 cites W2124602789 @default.
• W4385632493 cites W2133274082 @default.
• W4385632493 cites W2152853007 @default.
• W4385632493 cites W2164650754 @default.
• W4385632493 cites W2301237734 @default.
• W4385632493 cites W2472456895 @default.
• W4385632493 cites W2594820540 @default.
• W4385632493 cites W2742811155 @default.
• W4385632493 cites W2769360644 @default.
• W4385632493 cites W2789707001 @default.
• W4385632493 cites W2791767508 @default.
• W4385632493 cites W2804155645 @default.
• W4385632493 cites W2806668299 @default.
• W4385632493 cites W2911416246 @default.
• W4385632493 cites W2920471770 @default.
• W4385632493 cites W2977682063 @default.
• W4385632493 cites W2982274340 @default.
• W4385632493 cites W3003972077 @default.
• W4385632493 cites W3008647644 @default.
• W4385632493 cites W3009646986 @default.
• W4385632493 cites W3012302012 @default.
• W4385632493 cites W3021031749 @default.
• W4385632493 cites W3041133588 @default.
• W4385632493 cites W3137990666 @default.
• W4385632493 cites W3162798025 @default.
• W4385632493 cites W3164129009 @default.
• W4385632493 cites W3195626332 @default.
• W4385632493 cites W3216511043 @default.
• W4385632493 cites W4200409608 @default.
• W4385632493 cites W4210709728 @default.
• W4385632493 cites W4211131570 @default.
• W4385632493 cites W4224306162 @default.
• W4385632493 cites W4225724531 @default.
• W4385632493 cites W4229508150 @default.
• W4385632493 cites W4282946977 @default.
• W4385632493 cites W4292381832 @default.
• W4385632493 cites W4306783667 @default.
• W4385632493 doi "https://doi.org/10.2147/ijgm.s420706" @default.
• W4385632493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37576910" @default.
• W4385632493 hasPublicationYear "2023" @default.
• W4385632493 type Work @default.
• W4385632493 citedByCount "0" @default.
• W4385632493 crossrefType "journal-article" @default.
• W4385632493 hasAuthorship W4385632493A5023700139 @default.
• W4385632493 hasAuthorship W4385632493A5038274859 @default.
• W4385632493 hasAuthorship W4385632493A5046728023 @default.
• W4385632493 hasAuthorship W4385632493A5050489000 @default.
• W4385632493 hasAuthorship W4385632493A5058152911 @default.
• W4385632493 hasAuthorship W4385632493A5062982554 @default.
• W4385632493 hasAuthorship W4385632493A5064149545 @default.
• W4385632493 hasAuthorship W4385632493A5072795022 @default.
• W4385632493 hasAuthorship W4385632493A5073808661 @default.
• W4385632493 hasAuthorship W4385632493A5079090183 @default.
• W4385632493 hasAuthorship W4385632493A5083089425 @default.
• W4385632493 hasAuthorship W4385632493A5087845425 @default.
• W4385632493 hasBestOaLocation W43856324931 @default.
• W4385632493 hasConcept C126322002 @default.
• W4385632493 hasConcept C143998085 @default.
• W4385632493 hasConcept C150903083 @default.
• W4385632493 hasConcept C181199279 @default.
• W4385632493 hasConcept C207001950 @default.
• W4385632493 hasConcept C2778653478 @default.
• W4385632493 hasConcept C2779728014 @default.
• W4385632493 hasConcept C2780559512 @default.
• W4385632493 hasConcept C2781197716 @default.
• W4385632493 hasConcept C50382708 @default.
• W4385632493 hasConcept C55493867 @default.
• W4385632493 hasConcept C60644358 @default.
• W4385632493 hasConcept C71924100 @default.
• W4385632493 hasConcept C86803240 @default.
• W4385632493 hasConceptScore W4385632493C126322002 @default.
• W4385632493 hasConceptScore W4385632493C143998085 @default.
• W4385632493 hasConceptScore W4385632493C150903083 @default.

• next