Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385633081> ?p ?o ?g. }
- W4385633081 endingPage "2071" @default.
- W4385633081 startingPage "2061" @default.
- W4385633081 abstract "Vitiligo is an autoimmune disease of the skin that targets pigment-producing melanocytes and results in patches of depigmentation that are visible as white spots. Recent research studies have yielded a strong mechanistic understanding of this disease. Fructus Ligustri Lucidi (FLL) has been used for premature graying of hair since ancient China and is currently used to treat vitiligo. However, the key biomarkers and mechanisms underlying FLL in vitiligo remain unclear. This study aimed to identify the potential biomarkers and mechanisms of FLL in vitiligo using network pharmacology analysis.The expression profiles of GSE65127 and GSE75819 were downloaded from the Gene Expression Omnibus database to identify differentially expressed genes (DEGs) between the vitiligo and healthy samples. Gene ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of DEGs were performed using R analyses. We performed R to further understand the functions of the critical targets. Cytoscape tools have facilitated network topology analysis. Molecular docking was performed using Auto Dock Vina software.The results showed that 13 DEGs were screened in vitiligo. Based on bioinformatics, network pharmacology and Western blot, we found that the critical targets of melanoma antigen recognized by 5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1) may be related to the mechanism of action of FLL in the treatment of vitiligo.TYRP1, as a melanocyte molecular biomarker, may be closely related to the underlying mechanism of FLL in the treatment of vitiligo via the inhibition of melanocyte death." @default.
- W4385633081 created "2023-08-08" @default.
- W4385633081 creator A5004829334 @default.
- W4385633081 creator A5005166077 @default.
- W4385633081 creator A5033239062 @default.
- W4385633081 creator A5049846276 @default.
- W4385633081 creator A5060735471 @default.
- W4385633081 creator A5073714819 @default.
- W4385633081 creator A5078397435 @default.
- W4385633081 creator A5083362426 @default.
- W4385633081 date "2023-08-01" @default.
- W4385633081 modified "2023-10-14" @default.
- W4385633081 title "Identification of Critical Biomarkers and Mechanisms of Fructus Ligustri Lucidi on Vitiligo Using Integrated Bioinformatics Analysis" @default.
- W4385633081 cites W2016696677 @default.
- W4385633081 cites W2091306452 @default.
- W4385633081 cites W2279201083 @default.
- W4385633081 cites W2279344912 @default.
- W4385633081 cites W2303288028 @default.
- W4385633081 cites W2512793550 @default.
- W4385633081 cites W2537623931 @default.
- W4385633081 cites W2605621988 @default.
- W4385633081 cites W2726032666 @default.
- W4385633081 cites W2746547913 @default.
- W4385633081 cites W2789988381 @default.
- W4385633081 cites W2896577563 @default.
- W4385633081 cites W2914030720 @default.
- W4385633081 cites W2927036568 @default.
- W4385633081 cites W2944105732 @default.
- W4385633081 cites W2945844837 @default.
- W4385633081 cites W2954474032 @default.
- W4385633081 cites W2966687792 @default.
- W4385633081 cites W2970534831 @default.
- W4385633081 cites W3001922907 @default.
- W4385633081 cites W3004467513 @default.
- W4385633081 cites W3091771080 @default.
- W4385633081 cites W3111912080 @default.
- W4385633081 cites W3114993964 @default.
- W4385633081 cites W3133818386 @default.
- W4385633081 cites W3166250787 @default.
- W4385633081 cites W3189254161 @default.
- W4385633081 cites W3199124118 @default.
- W4385633081 cites W3199376621 @default.
- W4385633081 cites W3199518108 @default.
- W4385633081 cites W3200736572 @default.
- W4385633081 cites W4200041560 @default.
- W4385633081 cites W4211244313 @default.
- W4385633081 cites W4225142559 @default.
- W4385633081 cites W4283722722 @default.
- W4385633081 cites W4308550863 @default.
- W4385633081 doi "https://doi.org/10.2147/ccid.s413733" @default.
- W4385633081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37575147" @default.
- W4385633081 hasPublicationYear "2023" @default.
- W4385633081 type Work @default.
- W4385633081 citedByCount "0" @default.
- W4385633081 crossrefType "journal-article" @default.
- W4385633081 hasAuthorship W4385633081A5004829334 @default.
- W4385633081 hasAuthorship W4385633081A5005166077 @default.
- W4385633081 hasAuthorship W4385633081A5033239062 @default.
- W4385633081 hasAuthorship W4385633081A5049846276 @default.
- W4385633081 hasAuthorship W4385633081A5060735471 @default.
- W4385633081 hasAuthorship W4385633081A5073714819 @default.
- W4385633081 hasAuthorship W4385633081A5078397435 @default.
- W4385633081 hasAuthorship W4385633081A5083362426 @default.
- W4385633081 hasBestOaLocation W43856330811 @default.
- W4385633081 hasConcept C104317684 @default.
- W4385633081 hasConcept C150194340 @default.
- W4385633081 hasConcept C152724338 @default.
- W4385633081 hasConcept C2777658100 @default.
- W4385633081 hasConcept C2779769559 @default.
- W4385633081 hasConcept C2779980618 @default.
- W4385633081 hasConcept C2781197716 @default.
- W4385633081 hasConcept C2987395477 @default.
- W4385633081 hasConcept C54355233 @default.
- W4385633081 hasConcept C60644358 @default.
- W4385633081 hasConcept C70721500 @default.
- W4385633081 hasConcept C86803240 @default.
- W4385633081 hasConceptScore W4385633081C104317684 @default.
- W4385633081 hasConceptScore W4385633081C150194340 @default.
- W4385633081 hasConceptScore W4385633081C152724338 @default.
- W4385633081 hasConceptScore W4385633081C2777658100 @default.
- W4385633081 hasConceptScore W4385633081C2779769559 @default.
- W4385633081 hasConceptScore W4385633081C2779980618 @default.
- W4385633081 hasConceptScore W4385633081C2781197716 @default.
- W4385633081 hasConceptScore W4385633081C2987395477 @default.
- W4385633081 hasConceptScore W4385633081C54355233 @default.
- W4385633081 hasConceptScore W4385633081C60644358 @default.
- W4385633081 hasConceptScore W4385633081C70721500 @default.
- W4385633081 hasConceptScore W4385633081C86803240 @default.
- W4385633081 hasLocation W43856330811 @default.
- W4385633081 hasLocation W43856330812 @default.
- W4385633081 hasOpenAccess W4385633081 @default.
- W4385633081 hasPrimaryLocation W43856330811 @default.
- W4385633081 hasRelatedWork W2056144049 @default.
- W4385633081 hasRelatedWork W2079003517 @default.
- W4385633081 hasRelatedWork W2092014637 @default.
- W4385633081 hasRelatedWork W2371105742 @default.
- W4385633081 hasRelatedWork W2622722492 @default.
- W4385633081 hasRelatedWork W2909382709 @default.