FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385635592> ?p ?o ?g. }

• W4385635592 endingPage "107241" @default.
• W4385635592 startingPage "107241" @default.
• W4385635592 abstract "Digoxin is a cardiac glycoside obtained from the leaves of the foxglove plant, Digitalis lanata. Several studies have described the safety of digoxin including various life-threatening events, notably cardiac arrhythmias. Early identification of high-risk patients and subsequent initiation of the utmost medical care are associated with a better prognosis. The assessment of serum digoxin levels, which is not always convenient, is the only tool used to evaluate the severity of digoxin exposure. However, the feasibility of this tool, particularly in resource-restricted countries, remains unclear. Therefore, the current study aimed to establish and validate a feasible alternative tool, a bedside nomogram, to identify pediatric patients diagnosed with acute digoxin intoxication who are at risk of developing serious arrhythmias. This was a two-phase, multicenter, retrospective study. The prevalence of serious arrhythmias was approximately 17%. Patients diagnosed with serious arrhythmias showed significantly higher serum digoxin, random blood glucose, and potassium levels but lower sodium, magnesium, and hemoglobin levels. Serious arrhythmias were associated with significantly lower P-R intervals, shorter QTc intervals, and more frequent digoxin effects (p < 0.05). The proposed nomogram showed that combining age and initial random blood glucose, sodium, and potassium levels could predict the future incidence of serious arrhythmia with an accuracy of 96.2% (sensitivity = 94.4%, specificity = 96.5%), an area under the curve (AUC) of 0.977, and p < 0.001. Validation of the proposed nomogram yielded an AUC for the nomogram probability of approximately 81%, and the AUC for the predicted probability using the developed model was 98.3%, indicating that both the validated model and the developed nomogram were significant predictors of serious arrhythmia. The utility of using the four-factor nomogram to determine the risk of serious arrhythmia in children exposed to an overdose of digoxin is comparable, if not superior, to the serum digoxin level." @default.
• W4385635592 created "2023-08-08" @default.
• W4385635592 creator A5020131265 @default.
• W4385635592 creator A5028537450 @default.
• W4385635592 creator A5044447061 @default.
• W4385635592 creator A5057673263 @default.
• W4385635592 creator A5078144649 @default.
• W4385635592 date "2023-09-01" @default.
• W4385635592 modified "2023-10-12" @default.
• W4385635592 title "Development and validation of a risk prediction nomogram for serious arrhythmias in acute digoxin toxicity among pediatrics: A multicenter study" @default.
• W4385635592 cites W1964126830 @default.
• W4385635592 cites W1970791851 @default.
• W4385635592 cites W1982486033 @default.
• W4385635592 cites W1989892188 @default.
• W4385635592 cites W1992778391 @default.
• W4385635592 cites W1993260096 @default.
• W4385635592 cites W1996749205 @default.
• W4385635592 cites W1996877405 @default.
• W4385635592 cites W2027364814 @default.
• W4385635592 cites W2060113295 @default.
• W4385635592 cites W2074879648 @default.
• W4385635592 cites W2089057143 @default.
• W4385635592 cites W2099523962 @default.
• W4385635592 cites W2100301312 @default.
• W4385635592 cites W2101196243 @default.
• W4385635592 cites W2102752459 @default.
• W4385635592 cites W2106550298 @default.
• W4385635592 cites W2117240954 @default.
• W4385635592 cites W2124311738 @default.
• W4385635592 cites W2126096214 @default.
• W4385635592 cites W2130913895 @default.
• W4385635592 cites W2131043707 @default.
• W4385635592 cites W2315388314 @default.
• W4385635592 cites W2321330884 @default.
• W4385635592 cites W2326136111 @default.
• W4385635592 cites W2326852430 @default.
• W4385635592 cites W2347099903 @default.
• W4385635592 cites W2423299304 @default.
• W4385635592 cites W2510352988 @default.
• W4385635592 cites W2594428468 @default.
• W4385635592 cites W2789907472 @default.
• W4385635592 cites W2885150510 @default.
• W4385635592 cites W2886132259 @default.
• W4385635592 cites W2886362585 @default.
• W4385635592 cites W2999077535 @default.
• W4385635592 cites W3012234868 @default.
• W4385635592 cites W3020945783 @default.
• W4385635592 cites W3120220251 @default.
• W4385635592 cites W3162731086 @default.
• W4385635592 cites W3168459328 @default.
• W4385635592 cites W3179065486 @default.
• W4385635592 cites W3189540584 @default.
• W4385635592 cites W3196438426 @default.
• W4385635592 cites W4220679073 @default.
• W4385635592 cites W4250403800 @default.
• W4385635592 cites W4312219551 @default.
• W4385635592 doi "https://doi.org/10.1016/j.toxicon.2023.107241" @default.
• W4385635592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37558139" @default.
• W4385635592 hasPublicationYear "2023" @default.
• W4385635592 type Work @default.
• W4385635592 citedByCount "0" @default.
• W4385635592 crossrefType "journal-article" @default.
• W4385635592 hasAuthorship W4385635592A5020131265 @default.
• W4385635592 hasAuthorship W4385635592A5028537450 @default.
• W4385635592 hasAuthorship W4385635592A5044447061 @default.
• W4385635592 hasAuthorship W4385635592A5057673263 @default.
• W4385635592 hasAuthorship W4385635592A5078144649 @default.
• W4385635592 hasConcept C126322002 @default.
• W4385635592 hasConcept C164705383 @default.
• W4385635592 hasConcept C177713679 @default.
• W4385635592 hasConcept C2776445394 @default.
• W4385635592 hasConcept C2777707475 @default.
• W4385635592 hasConcept C2778198053 @default.
• W4385635592 hasConcept C34626388 @default.
• W4385635592 hasConcept C71924100 @default.
• W4385635592 hasConceptScore W4385635592C126322002 @default.
• W4385635592 hasConceptScore W4385635592C164705383 @default.
• W4385635592 hasConceptScore W4385635592C177713679 @default.
• W4385635592 hasConceptScore W4385635592C2776445394 @default.
• W4385635592 hasConceptScore W4385635592C2777707475 @default.
• W4385635592 hasConceptScore W4385635592C2778198053 @default.
• W4385635592 hasConceptScore W4385635592C34626388 @default.
• W4385635592 hasConceptScore W4385635592C71924100 @default.
• W4385635592 hasLocation W43856355921 @default.
• W4385635592 hasLocation W43856355922 @default.
• W4385635592 hasOpenAccess W4385635592 @default.
• W4385635592 hasPrimaryLocation W43856355921 @default.
• W4385635592 hasRelatedWork W1970018641 @default.
• W4385635592 hasRelatedWork W2034094480 @default.
• W4385635592 hasRelatedWork W2074659607 @default.
• W4385635592 hasRelatedWork W2075445917 @default.
• W4385635592 hasRelatedWork W2411730362 @default.
• W4385635592 hasRelatedWork W2412456273 @default.
• W4385635592 hasRelatedWork W2443625294 @default.
• W4385635592 hasRelatedWork W2469880501 @default.
• W4385635592 hasRelatedWork W4231402705 @default.
• W4385635592 hasRelatedWork W192573810 @default.
• W4385635592 hasVolume "233" @default.

• next