Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385636211> ?p ?o ?g. }
- W4385636211 endingPage "12520" @default.
- W4385636211 startingPage "12520" @default.
- W4385636211 abstract "The cure rate for metastatic or relapsed osteosarcoma has not substantially improved over the past decades despite the exploitation of multimodal treatment approaches, allowing long-term survival in less than 30% of cases. Patients with osteosarcoma often develop resistance to chemotherapeutic agents, where personalized targeted therapies should offer new hope. T cell immunotherapy as a complementary or alternative treatment modality is advancing rapidly in general, but its potential against osteosarcoma remains largely unexplored. Strategies incorporating immune checkpoint inhibitors (ICIs), chimeric antigen receptor (CAR) modified T cells, and T cell engaging bispecific antibodies (BsAbs) are being explored to tackle relapsed or refractory osteosarcoma. However, osteosarcoma is an inherently heterogeneous tumor, both at the intra- and inter-tumor level, with no identical driver mutations. It has a pro-tumoral microenvironment, where bone cells, stromal cells, neovasculature, suppressive immune cells, and a mineralized extracellular matrix (ECM) combine to derail T cell infiltration and its anti-tumor function. To realize the potential of T cell immunotherapy in osteosarcoma, an integrated approach targeting this complex ecosystem needs smart planning and execution. Herein, we review the current status of T cell immunotherapies for osteosarcoma, summarize the challenges encountered, and explore combination strategies to overcome these hurdles, with the ultimate goal of curing osteosarcoma with less acute and long-term side effects." @default.
- W4385636211 created "2023-08-08" @default.
- W4385636211 creator A5006088774 @default.
- W4385636211 creator A5014211951 @default.
- W4385636211 date "2023-08-07" @default.
- W4385636211 modified "2023-09-26" @default.
- W4385636211 title "Promise and Challenges of T Cell Immunotherapy for Osteosarcoma" @default.
- W4385636211 cites W1169009615 @default.
- W4385636211 cites W1192540099 @default.
- W4385636211 cites W1513821330 @default.
- W4385636211 cites W1539751281 @default.
- W4385636211 cites W1543079591 @default.
- W4385636211 cites W1614553858 @default.
- W4385636211 cites W1931737153 @default.
- W4385636211 cites W1936567301 @default.
- W4385636211 cites W1971992475 @default.
- W4385636211 cites W1978436252 @default.
- W4385636211 cites W1986690159 @default.
- W4385636211 cites W1990189227 @default.
- W4385636211 cites W1993617345 @default.
- W4385636211 cites W1997066354 @default.
- W4385636211 cites W1998166655 @default.
- W4385636211 cites W2000677573 @default.
- W4385636211 cites W2002267497 @default.
- W4385636211 cites W2005449663 @default.
- W4385636211 cites W2011458181 @default.
- W4385636211 cites W2011912935 @default.
- W4385636211 cites W2011944525 @default.
- W4385636211 cites W2015474424 @default.
- W4385636211 cites W2016983859 @default.
- W4385636211 cites W2026537544 @default.
- W4385636211 cites W2027863358 @default.
- W4385636211 cites W2035852466 @default.
- W4385636211 cites W2038476799 @default.
- W4385636211 cites W2040159457 @default.
- W4385636211 cites W2048345613 @default.
- W4385636211 cites W2048752843 @default.
- W4385636211 cites W2050698267 @default.
- W4385636211 cites W2055916341 @default.
- W4385636211 cites W2058648826 @default.
- W4385636211 cites W2072041272 @default.
- W4385636211 cites W2072451938 @default.
- W4385636211 cites W2073908904 @default.
- W4385636211 cites W2077871666 @default.
- W4385636211 cites W2084142018 @default.
- W4385636211 cites W2094366129 @default.
- W4385636211 cites W2095599995 @default.
- W4385636211 cites W2097855813 @default.
- W4385636211 cites W2098054841 @default.
- W4385636211 cites W2099824657 @default.
- W4385636211 cites W2103405666 @default.
- W4385636211 cites W2104839914 @default.
- W4385636211 cites W2105009956 @default.
- W4385636211 cites W2112680373 @default.
- W4385636211 cites W2114974670 @default.
- W4385636211 cites W2120159810 @default.
- W4385636211 cites W2123107246 @default.
- W4385636211 cites W2125028197 @default.
- W4385636211 cites W2128125459 @default.
- W4385636211 cites W2130822830 @default.
- W4385636211 cites W2135947389 @default.
- W4385636211 cites W2137816700 @default.
- W4385636211 cites W2139619092 @default.
- W4385636211 cites W2143743735 @default.
- W4385636211 cites W2146684793 @default.
- W4385636211 cites W2157003991 @default.
- W4385636211 cites W2157691319 @default.
- W4385636211 cites W2169876627 @default.
- W4385636211 cites W2212174305 @default.
- W4385636211 cites W2220679566 @default.
- W4385636211 cites W2273287551 @default.
- W4385636211 cites W2314452004 @default.
- W4385636211 cites W2330978427 @default.
- W4385636211 cites W2407062242 @default.
- W4385636211 cites W2462177828 @default.
- W4385636211 cites W2491306389 @default.
- W4385636211 cites W2495822834 @default.
- W4385636211 cites W2504729294 @default.
- W4385636211 cites W2511951051 @default.
- W4385636211 cites W2517335663 @default.
- W4385636211 cites W2577284382 @default.
- W4385636211 cites W2586164131 @default.
- W4385636211 cites W2591709377 @default.
- W4385636211 cites W2597042866 @default.
- W4385636211 cites W2616230058 @default.
- W4385636211 cites W2616637874 @default.
- W4385636211 cites W2621108701 @default.
- W4385636211 cites W2624408765 @default.
- W4385636211 cites W2627067328 @default.
- W4385636211 cites W2692723694 @default.
- W4385636211 cites W2752145776 @default.
- W4385636211 cites W2762797139 @default.
- W4385636211 cites W2763751953 @default.
- W4385636211 cites W2767343890 @default.
- W4385636211 cites W2774372124 @default.
- W4385636211 cites W2783070348 @default.
- W4385636211 cites W2797890752 @default.
- W4385636211 cites W2799967447 @default.