FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385636699> ?p ?o ?g. }

• W4385636699 abstract "Abstract Eye‐drop treatments of age‐related macular degeneration (AMD) are desirable; however, no clinically approved eye drop has been reported to date. This study aim to evaluate the therapeutic activity of eye‐drop instillation of a high‐density lipoprotein (HDL) variant bearing a cell‐penetrating peptide and neovasculature‐targeted peptide (AsnGlyArg [NGR] peptide) in a mouse model at a dose of 0.6–0.85 µg protein/eye drop. The results reveal that the activity of the abovementioned variant was >10‐fold higher than that of the previous variant lacking an NGR peptide. In addition, the anti‐inflammatory activity, cholesterol‐efflux capacity, and antiangiogenic activity of reconstituted HDL are significantly augmented by the attachment of these two peptides. The mechanism underlying this dramatic improvement is likely the expression of CD13, an NGR peptide receptor, on the cornea and conjunctiva in mice. CD13 mRNA/protein expression is also detected in cultured human corneal and conjunctival cells. These results demonstrate that NGR peptide is an unprecedented class of an absorption enhancer on the eye surface. Thus, HDL engineering is a potential strategy for developing eye drops to treat neovascular AMD by enhancing the ocular surface absorption and HDL functionalities." @default.
• W4385636699 created "2023-08-08" @default.
• W4385636699 creator A5008059619 @default.
• W4385636699 creator A5012508418 @default.
• W4385636699 creator A5021251912 @default.
• W4385636699 creator A5032803340 @default.
• W4385636699 creator A5037165196 @default.
• W4385636699 creator A5046598629 @default.
• W4385636699 creator A5049463882 @default.
• W4385636699 creator A5067618942 @default.
• W4385636699 creator A5073257627 @default.
• W4385636699 creator A5085054120 @default.
• W4385636699 creator A5091435401 @default.
• W4385636699 creator A5091593293 @default.
• W4385636699 creator A5092792983 @default.
• W4385636699 creator A5092792984 @default.
• W4385636699 creator A5092792985 @default.
• W4385636699 creator A5092792986 @default.
• W4385636699 date "2023-08-25" @default.
• W4385636699 modified "2023-10-16" @default.
• W4385636699 title "High‐Density Lipoprotein Engineering for Eye‐Drop Treatment of Age‐Related Macular Degeneration" @default.
• W4385636699 cites W1587050401 @default.
• W4385636699 cites W1964993258 @default.
• W4385636699 cites W2011759191 @default.
• W4385636699 cites W2014123675 @default.
• W4385636699 cites W2035542493 @default.
• W4385636699 cites W2040296447 @default.
• W4385636699 cites W2050546552 @default.
• W4385636699 cites W2052849118 @default.
• W4385636699 cites W2057486197 @default.
• W4385636699 cites W2066082534 @default.
• W4385636699 cites W2082780712 @default.
• W4385636699 cites W2114343361 @default.
• W4385636699 cites W2116775019 @default.
• W4385636699 cites W2120100584 @default.
• W4385636699 cites W2124209549 @default.
• W4385636699 cites W2154805215 @default.
• W4385636699 cites W2612951191 @default.
• W4385636699 cites W2762049027 @default.
• W4385636699 cites W2809165562 @default.
• W4385636699 cites W2957374179 @default.
• W4385636699 cites W3008159823 @default.
• W4385636699 cites W3013187457 @default.
• W4385636699 cites W3043557692 @default.
• W4385636699 cites W3131228210 @default.
• W4385636699 cites W3137711378 @default.
• W4385636699 cites W3168827864 @default.
• W4385636699 cites W4211199473 @default.
• W4385636699 cites W4213111119 @default.
• W4385636699 doi "https://doi.org/10.1002/adtp.202300186" @default.
• W4385636699 hasPublicationYear "2023" @default.
• W4385636699 type Work @default.
• W4385636699 citedByCount "0" @default.
• W4385636699 crossrefType "journal-article" @default.
• W4385636699 hasAuthorship W4385636699A5008059619 @default.
• W4385636699 hasAuthorship W4385636699A5012508418 @default.
• W4385636699 hasAuthorship W4385636699A5021251912 @default.
• W4385636699 hasAuthorship W4385636699A5032803340 @default.
• W4385636699 hasAuthorship W4385636699A5037165196 @default.
• W4385636699 hasAuthorship W4385636699A5046598629 @default.
• W4385636699 hasAuthorship W4385636699A5049463882 @default.
• W4385636699 hasAuthorship W4385636699A5067618942 @default.
• W4385636699 hasAuthorship W4385636699A5073257627 @default.
• W4385636699 hasAuthorship W4385636699A5085054120 @default.
• W4385636699 hasAuthorship W4385636699A5091435401 @default.
• W4385636699 hasAuthorship W4385636699A5091593293 @default.
• W4385636699 hasAuthorship W4385636699A5092792983 @default.
• W4385636699 hasAuthorship W4385636699A5092792984 @default.
• W4385636699 hasAuthorship W4385636699A5092792985 @default.
• W4385636699 hasAuthorship W4385636699A5092792986 @default.
• W4385636699 hasBestOaLocation W43856366991 @default.
• W4385636699 hasConcept C118487528 @default.
• W4385636699 hasConcept C126322002 @default.
• W4385636699 hasConcept C134018914 @default.
• W4385636699 hasConcept C170493617 @default.
• W4385636699 hasConcept C185592680 @default.
• W4385636699 hasConcept C203014093 @default.
• W4385636699 hasConcept C2775984611 @default.
• W4385636699 hasConcept C2776403814 @default.
• W4385636699 hasConcept C2776882836 @default.
• W4385636699 hasConcept C2777625524 @default.
• W4385636699 hasConcept C2778163477 @default.
• W4385636699 hasConcept C2779281246 @default.
• W4385636699 hasConcept C2780072125 @default.
• W4385636699 hasConcept C55493867 @default.
• W4385636699 hasConcept C71924100 @default.
• W4385636699 hasConceptScore W4385636699C118487528 @default.
• W4385636699 hasConceptScore W4385636699C126322002 @default.
• W4385636699 hasConceptScore W4385636699C134018914 @default.
• W4385636699 hasConceptScore W4385636699C170493617 @default.
• W4385636699 hasConceptScore W4385636699C185592680 @default.
• W4385636699 hasConceptScore W4385636699C203014093 @default.
• W4385636699 hasConceptScore W4385636699C2775984611 @default.
• W4385636699 hasConceptScore W4385636699C2776403814 @default.
• W4385636699 hasConceptScore W4385636699C2776882836 @default.
• W4385636699 hasConceptScore W4385636699C2777625524 @default.
• W4385636699 hasConceptScore W4385636699C2778163477 @default.
• W4385636699 hasConceptScore W4385636699C2779281246 @default.
• W4385636699 hasConceptScore W4385636699C2780072125 @default.
• W4385636699 hasConceptScore W4385636699C55493867 @default.

• next