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• W4385638500 abstract "Iron is essential for growth in most bacteria due to its redox activity and its role in essential metabolic reactions; it is a cofactor for many bacterial enzymes. The bacterium Acinetobacter baumannii is a multidrug-resistant nosocomial pathogen. A. baumannii responds to low iron availability imposed by the host through the exploitation of multiple iron-acquisition strategies, which are likely to deliver iron to the cell under a variety of environmental conditions, including human and animal infection. To date, six different gene clusters for active iron uptake have been described in A. baumannii , encoding protein systems involved in (i) ferrous iron uptake ( feo ); (ii) haem uptake ( hemT and hemO ); and (iii) synthesis and transport of the baumannoferrin(s) ( bfn ), acinetobactin ( bas / bau ) and fimsbactin(s) ( fbs ) siderophores. Here we describe the structure, distribution and phylogeny of iron-uptake gene clusters among >1000 genotypically diverse A. baumannii isolates, showing that feo , hemT , bfn and bas / bau clusters are very prevalent across the dataset, whereas the additional haem-uptake system hemO is only present in a portion of the dataset and the fbs gene cluster is very rare. Since the expression of multiple iron-uptake clusters can be linked to virulence, the presence of the additional haem-uptake system hemO may have contributed to the success of some A. baumannii clones." @default.
• W4385638500 created "2023-08-08" @default.
• W4385638500 creator A5042512565 @default.
• W4385638500 creator A5050658340 @default.
• W4385638500 creator A5056479528 @default.
• W4385638500 creator A5088745445 @default.
• W4385638500 date "2023-08-07" @default.
• W4385638500 modified "2023-09-30" @default.
• W4385638500 title "Genomics of Acinetobacter baumannii iron uptake" @default.
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• W4385638500 doi "https://doi.org/10.1099/mgen.0.001080" @default.
• W4385638500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37549061" @default.
• W4385638500 hasPublicationYear "2023" @default.
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