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• W4385639506 abstract "<h3>Background</h3> We aimed to evaluate the effect of Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) and Definition Of Remission In SLE (DORIS) remission state on damage accrual in SLE. <h3>Methods</h3> We defined SLE patients from Lupus Clinic of Royal Thai Army (LUCRA) cohort based on Index and Boolean-based SLE-DAS and DORIS for remission state. Those who were not in any remission definitions were defined as non-remission status. Sustained remission was defined as those with prolonged remission state for ≥ 1 year. Regression analysis models were constructed to identify predictors of the Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) during follow up. <h3>Results</h3> There were 198 patients identified: 98 patients met at least 1 definition of sustain remission state and 100 patients in non-remission group. Of 98 patients, 97 patients were achieved Index-based definitions, 75 patients achieved Boolean-based definition, and 55 patients were achieved Doria definition. The mean ± SD of follow up was 4.77 ± 0.6 years. The changes in SDI over time were non-significant lower in patient who met any definition of remission compared with those who not. Multivariable analysis revealed that predictive factors of increased SDI were age (HR 1.03, p = 0.01) and baseline SDI ≥ 1 (HR 2.54, p = 0.01). However, Index, Boolean, and Doria-based definition of remission had no significant relative risk reduction on SDI compared with non-remission group (HR 0.7, p= 0.27; HR 0.73, p =0.37; HR 0.8, p= 0.55, respectively). <h3>Conclusions</h3> To achieve sustained remission state based on definitions of SLE-DAS and DORIS showed relative protective effect on damage accrual compared to non-remission status, but not statistically significant. These definitions had a comparable effect and could be used as the treatment goal of treat to target strategies in SLE. <h3>References</h3> Jesus D, Matos A, Henriques C, Zen M, Larosa M, Iaccarino L, Da Silva JAP, Doria A, Inês LS. Derivation and validation of the SLE Disease Activity Score (SLE-DAS): a new SLE continuous measure with high sensitivity for changes in disease activity. <i>Ann Rheum Dis</i> 2019 Mar;<b>78</b>(3):365–371. Jesus D, Larosa M, Henriques C, Matos A, Zen M, Tomé P, Alves V, Costa N, Le Guern V, Iaccarino L, Costedoat-Chalumeau N, Doria A, Inês LS. Systemic Lupus Erythematosus Disease Activity Score (SLE-DAS) enables accurate and user-friendly definitions of clinical remission and categories of disease activity. <i>Ann Rheum Dis</i> 2021 Dec;<b>80</b>(12):1568–1574." @default.
• W4385639506 created "2023-08-08" @default.
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• W4385639506 date "2023-07-01" @default.
• W4385639506 modified "2023-10-05" @default.
• W4385639506 title "LP-055 The effect of different remission definitions in patients with systemic lupus erythematosus on damage accrual: data from the LUCRA cohort" @default.
• W4385639506 doi "https://doi.org/10.1136/lupus-2023-kcr.165" @default.
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