FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385641692> ?p ?o ?g. }

• W4385641692 endingPage "1000" @default.
• W4385641692 startingPage "997" @default.
• W4385641692 abstract "In obese men, sex hormone-binding globulin levels (SHBG) as well as total plasma testosterone (T) levels are decreased. Data concerning the levels of nonprotein-bound testosterone (FT) are discordant, with some researchers reporting normal levels, and other reporting decreased levels. The latter imply an impairment of the feedback regulation mechanism of FT levels. We investigated whether an eventual decrease in FT levels and, hence, functional impairment of the gonadostat might occur only at a more severe degree of obesity than that required for a decrease in SHBG and total T levels. We, therefore, determined androgen and precursor levels in three groups of male subjects: nonobese controls [body mass index (BMI), G (kg)/L2 (m) < 26; n = 70]; moderately (BMI, 30-35; n = 18), and severely (BMI, > 40; n = 22) obese men, respectively. In a subgroup of these controls, moderately and severely obese subjects, respectively, we studied LH levels as well as LH pulsatility. Moreover, as a decrease in FT levels might affect the metabolic pattern of the androgens and, more specifically, 5 alpha-reductase activity, we determined the plasma levels of the major 5 alpha-reduced metabolites, androstanediol glucuronide and androsterone glucuronide (AG), as well as the urinary excretion of the major 5 alpha (androsterone glucuronide) and the major 5 beta (etiocholanolone glucuronide) metabolite of the androgens. In moderately obese men, T levels were decreased, which was the consequence of the decreased SHBG-binding capacity. FT levels, however, were normal as were LH levels and both pulse amplitude and frequency of LH pulses, suggesting a normal hypothalamic control of LH secretion. In severely obese men (BMI, > 40), total T, FT, and LH levels as well as LH pulse amplitude were decreased, indicating a functional impairment of the gonadostat. Even in massively obese subjects with decreased FT levels, androgen metabolism and 5 alpha-reductase activity appeared to be normal, as suggested by similar androstanediol glucuronide and AG levels, determined by RIA or calculated from the conversion rates of precursors obtained in nonobese subjects. This was confirmed by the similar AG/eticholanolone glucuronide ratios in obese and nonobese men.(ABSTRACT TRUNCATED AT 400 WORDS)" @default.
• W4385641692 created "2023-08-08" @default.
• W4385641692 creator A5013603374 @default.
• W4385641692 creator A5064793416 @default.
• W4385641692 creator A5073876349 @default.
• W4385641692 date "1994-10-01" @default.
• W4385641692 modified "2023-10-02" @default.
• W4385641692 title "Pathogenesis of the decreased androgen levels in obese men." @default.
• W4385641692 doi "https://doi.org/10.1210/jcem.79.4.7962311" @default.
• W4385641692 hasPublicationYear "1994" @default.
• W4385641692 type Work @default.
• W4385641692 citedByCount "12" @default.
• W4385641692 countsByYear W43856416922017 @default.
• W4385641692 countsByYear W43856416922018 @default.
• W4385641692 countsByYear W43856416922020 @default.
• W4385641692 countsByYear W43856416922021 @default.
• W4385641692 countsByYear W43856416922022 @default.
• W4385641692 countsByYear W43856416922023 @default.
• W4385641692 crossrefType "journal-article" @default.
• W4385641692 hasAuthorship W4385641692A5013603374 @default.
• W4385641692 hasAuthorship W4385641692A5064793416 @default.
• W4385641692 hasAuthorship W4385641692A5073876349 @default.
• W4385641692 hasConcept C126322002 @default.
• W4385641692 hasConcept C134018914 @default.
• W4385641692 hasConcept C2777477808 @default.
• W4385641692 hasConcept C2777911890 @default.
• W4385641692 hasConcept C2779186261 @default.
• W4385641692 hasConcept C2779279991 @default.
• W4385641692 hasConcept C2779746161 @default.
• W4385641692 hasConcept C2780221984 @default.
• W4385641692 hasConcept C2780902042 @default.
• W4385641692 hasConcept C30092816 @default.
• W4385641692 hasConcept C71315377 @default.
• W4385641692 hasConcept C71924100 @default.
• W4385641692 hasConceptScore W4385641692C126322002 @default.
• W4385641692 hasConceptScore W4385641692C134018914 @default.
• W4385641692 hasConceptScore W4385641692C2777477808 @default.
• W4385641692 hasConceptScore W4385641692C2777911890 @default.
• W4385641692 hasConceptScore W4385641692C2779186261 @default.
• W4385641692 hasConceptScore W4385641692C2779279991 @default.
• W4385641692 hasConceptScore W4385641692C2779746161 @default.
• W4385641692 hasConceptScore W4385641692C2780221984 @default.
• W4385641692 hasConceptScore W4385641692C2780902042 @default.
• W4385641692 hasConceptScore W4385641692C30092816 @default.
• W4385641692 hasConceptScore W4385641692C71315377 @default.
• W4385641692 hasConceptScore W4385641692C71924100 @default.
• W4385641692 hasIssue "4" @default.
• W4385641692 hasLocation W43856416921 @default.
• W4385641692 hasOpenAccess W4385641692 @default.
• W4385641692 hasPrimaryLocation W43856416921 @default.
• W4385641692 hasRelatedWork W1967975371 @default.
• W4385641692 hasRelatedWork W1970132895 @default.
• W4385641692 hasRelatedWork W1976801771 @default.
• W4385641692 hasRelatedWork W1981433740 @default.
• W4385641692 hasRelatedWork W1986311037 @default.
• W4385641692 hasRelatedWork W2002995968 @default.
• W4385641692 hasRelatedWork W2053511509 @default.
• W4385641692 hasRelatedWork W2083564258 @default.
• W4385641692 hasRelatedWork W4385641692 @default.
• W4385641692 hasRelatedWork W2036011095 @default.
• W4385641692 hasVolume "79" @default.
• W4385641692 isParatext "false" @default.
• W4385641692 isRetracted "false" @default.
• W4385641692 workType "article" @default.