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- W4385644014 abstract "There are conflicting estimates of the duration of mouse primary follicle development. An accurate determination is needed for studies examining preantral follicle survival and mathematical modelling of folliculogenesis. Primary follicle granulosa cell proliferation rates are low and variable which may explain the variation in duration estimates. In the present study, female C57Bl6/J mice were exposed to bromodeoxyuridine (BrdU) for 48 hours, to label the proliferating granulosa cells in a large proportion of primary follicles. The BrdU-containing water was then withdrawn and replaced with drug-free water and the mice were euthanised at 0, 1, 3, 6, 10 or 13 days post-BrdU-withdrawal. Granulosa cells were BrdU-labelled in 48% of primary follicles at day 0 but this decreased to 5% over the 13-day period, as the labelled primary follicles progressed to the secondary follicle stage. Curve-fitting estimated that the last of the BrdU-labelled primary follicles would progress to the secondary stage by 13.7 days. Mathematical models that assumed constant rates of primary follicle proliferation were fitted to the data but the observed pattern of BrdU-labelled primary follicle disappearance could not be replicated. The level of immunoreactivity for BrdU and proliferating-cell nuclear antigen (PCNA) in primary follicles revealed follicles with no granulosa cell proliferation during the 48-hour BrdU-exposure period, had resumed proliferation 1 or 3 days later. Therefore, primary follicle granulosa cells proliferate after follicle activation but proliferation rates gradually increase as the follicle develops. Prior estimates of primary follicle duration are inaccurate due to the assumption that follicles develop at a constant rate." @default.
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- W4385644014 date "2023-08-08" @default.
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- W4385644014 title "Mouse primary follicles experience slow growth rates after activation and progressive increases that influence the duration of the primary follicle phase" @default.
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- W4385644014 doi "https://doi.org/10.1093/biolre/ioad095" @default.
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