FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385647585> ?p ?o ?g. }

• W4385647585 abstract "ABSTRACT Introduction Noncompressible torso hemorrhage (NCTH) accounts for most potentially survivable deaths on the battlefield. Treatment of NCTH is challenging, especially in far-forward environments with limited capabilities. Resuscitative endovascular balloon occlusion of the aorta (REBOA) has shown promise in the care of patients with NCTH. REBOA involves introducing a balloon catheter into the descending aorta in a specific occlusion region (zones 1, 2, or 3) and acts as a hemorrhage control adjunct with resuscitative support. The balloon is placed in zone 3 in the infrarenal aorta for high junctional or pelvic injuries and in zone 1 proximal to the diaphragm for torso hemorrhage. Zone 1 REBOA provides more resuscitative support than zone 3; however, the potential for ischemia and reperfusion injuries is greater with zone 1 than with zone 3 REBOA placement. This study aims to determine the possible benefit of transitioning the REBOA balloon from zone 3 to zone 1 to rescue a patient with ongoing venous bleeding and impending cardiovascular collapse. Materials and Methods Yorkshire male swine (70–90 kg, n = 6 per group) underwent injury to the femoral artery, which was allowed to bleed freely for 60 s, along with a simultaneous controlled venous hemorrhage. After 60 s, the arterial bleed was controlled with hemostatic gauze and zone 3 REBOA was inflated. Five hundred milliliters of Hextend was used for initial fluid resuscitation. The controlled venous bleed continued until a mean arterial pressure (MAP) of 30 mmHg was reached to create an impending cardiovascular collapse. The animals were then randomized into either continued zone 3 REBOA or transition from zone 3 to zone 1 REBOA. Following 30 min, a “hospital phase” was initiated, consisting of cessation of the venous hemorrhage, deflation of the REBOA balloon, and transfusion of one unit of whole blood administered along with saline and norepinephrine to maintain a MAP of 60 mmHg or higher. The animals then underwent a 2-h observation period. Survival, hemodynamics, and blood chemistries were compared between groups. Results No significant differences between groups were observed in hemodynamic or laboratory values at baseline, postinitial injury, or when MAP reached 30 mmHg. Survival was significantly longer in animals that transitioned into zone 1 REBOA (log-rank analysis, P = .012). The average time of survival was 14 ± 10 min for zone 3 animals vs. 65 ± 59 min for zone 1 animals (P = .064). No animals in the zone 3 group survived to the hospital phase. Zone 1–treated animals showed immediate hemodynamic improvement after transition, with maximum blood pressure reaching near baseline values compared to those in the zone 3 group. Conclusions In this swine model of NCTH, hemodynamics and survival were improved when the REBOA balloon was transitioned from zone 3 to zone 1 during an impending cardiovascular collapse. Furthermore, these improved outcome data support the pursuit of additional research into mitigating ischemia–reperfusion insult to the abdominal viscera while still providing excellent resuscitative support, such as intermittent or partial REBOA." @default.
• W4385647585 created "2023-08-09" @default.
• W4385647585 creator A5053262193 @default.
• W4385647585 creator A5063069471 @default.
• W4385647585 creator A5077268445 @default.
• W4385647585 creator A5083901038 @default.
• W4385647585 creator A5086402869 @default.
• W4385647585 date "2023-08-08" @default.
• W4385647585 modified "2023-09-27" @default.
• W4385647585 title "Transition of Resuscitative Endovascular Balloon Occlusion of the Aorta from Zone 3 to Zone 1 to Treat Hemodynamic Collapse during Continued Hemorrhage" @default.
• W4385647585 cites W1986387726 @default.
• W4385647585 cites W2015340805 @default.
• W4385647585 cites W2024393355 @default.
• W4385647585 cites W2067586272 @default.
• W4385647585 cites W2083180828 @default.
• W4385647585 cites W2090729224 @default.
• W4385647585 cites W2125705929 @default.
• W4385647585 cites W2150100219 @default.
• W4385647585 cites W2762444358 @default.
• W4385647585 cites W2800322380 @default.
• W4385647585 cites W2801768547 @default.
• W4385647585 cites W2886412854 @default.
• W4385647585 cites W2886513745 @default.
• W4385647585 cites W2921131778 @default.
• W4385647585 cites W2955504961 @default.
• W4385647585 cites W2973907740 @default.
• W4385647585 cites W3010720751 @default.
• W4385647585 cites W3035891496 @default.
• W4385647585 cites W3117060979 @default.
• W4385647585 cites W4200627803 @default.
• W4385647585 cites W4213152451 @default.
• W4385647585 doi "https://doi.org/10.1093/milmed/usad313" @default.
• W4385647585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37552642" @default.
• W4385647585 hasPublicationYear "2023" @default.
• W4385647585 type Work @default.
• W4385647585 citedByCount "0" @default.
• W4385647585 crossrefType "journal-article" @default.
• W4385647585 hasAuthorship W4385647585A5053262193 @default.
• W4385647585 hasAuthorship W4385647585A5063069471 @default.
• W4385647585 hasAuthorship W4385647585A5077268445 @default.
• W4385647585 hasAuthorship W4385647585A5083901038 @default.
• W4385647585 hasAuthorship W4385647585A5086402869 @default.
• W4385647585 hasBestOaLocation W43856475851 @default.
• W4385647585 hasConcept C126322002 @default.
• W4385647585 hasConcept C139059822 @default.
• W4385647585 hasConcept C141071460 @default.
• W4385647585 hasConcept C2776259030 @default.
• W4385647585 hasConcept C2778165595 @default.
• W4385647585 hasConcept C2779980429 @default.
• W4385647585 hasConcept C2781300812 @default.
• W4385647585 hasConcept C2993470428 @default.
• W4385647585 hasConcept C42219234 @default.
• W4385647585 hasConcept C71924100 @default.
• W4385647585 hasConceptScore W4385647585C126322002 @default.
• W4385647585 hasConceptScore W4385647585C139059822 @default.
• W4385647585 hasConceptScore W4385647585C141071460 @default.
• W4385647585 hasConceptScore W4385647585C2776259030 @default.
• W4385647585 hasConceptScore W4385647585C2778165595 @default.
• W4385647585 hasConceptScore W4385647585C2779980429 @default.
• W4385647585 hasConceptScore W4385647585C2781300812 @default.
• W4385647585 hasConceptScore W4385647585C2993470428 @default.
• W4385647585 hasConceptScore W4385647585C42219234 @default.
• W4385647585 hasConceptScore W4385647585C71924100 @default.
• W4385647585 hasFunder F4320337792 @default.
• W4385647585 hasLocation W43856475851 @default.
• W4385647585 hasLocation W43856475852 @default.
• W4385647585 hasOpenAccess W4385647585 @default.
• W4385647585 hasPrimaryLocation W43856475851 @default.
• W4385647585 hasRelatedWork W1989747685 @default.
• W4385647585 hasRelatedWork W1993015106 @default.
• W4385647585 hasRelatedWork W2018574004 @default.
• W4385647585 hasRelatedWork W2025435709 @default.
• W4385647585 hasRelatedWork W2118496982 @default.
• W4385647585 hasRelatedWork W2149899029 @default.
• W4385647585 hasRelatedWork W2678470159 @default.
• W4385647585 hasRelatedWork W2900078337 @default.
• W4385647585 hasRelatedWork W4286852194 @default.
• W4385647585 hasRelatedWork W3031396723 @default.
• W4385647585 isParatext "false" @default.
• W4385647585 isRetracted "false" @default.
• W4385647585 workType "article" @default.