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- W4385652175 abstract "Zingerone is a flavor phytochemical present in ginger, a flowering plant belonging to the Zingiberaceae family used as a condiment and herbal remedy. It possesses anti-inflammatory, antioxidant, and anti-apoptotic properties and also exhibits protective effects against radiation, chemicals, biological toxins, and oxidative stress. The current comprehensive literature review was performed in order to assess the therapeutical and protective properties of zingerone against various chemical and natural toxins by considering the mechanisms of action. Extensive searches were performed on Scopus, Web of Science, PubMed, and Google Scholar databases. Zingerone lessens oxidative stress, inflammation, apoptosis, and oxidative DNA damage by increasing the activities of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GPX). It prevents alginate production, which increases the cell's susceptibility to macrophages, serum, and antibiotics and dramatically lowers the generation of proinflammatory cytokines brought on by lipopolysaccharide (LPS). Cytokine production, MAPK, and NF-κB activation are all inhibited dose-dependently by zingerone. Zingerone also reduces 8-OHdG over-expression in the liver tissue and the expression of NADPH oxidase 4 (NOX4), inflammatory cytokines (e.g., IFN-γ, IL-17, IL-6, COX-2, TNF-α, and iNOS mRNA level), decreases macrophage inflammatory protein cytokines and eliminates free radicals. It also suppresses matrix metalloproteinase-2 (MMP-2) and MMP-9 during tumor progression, showing its anti-angiogenic activity. Strong radioprotective properties of zingerone are demonstrated against radiation-induced toxicity. The authors hope this review gives researchers some insight into conducting novel clinical and preclinical studies on pharmaceutical applications and the efficiency of zingerone in cancer treatment, and drug adverse effects." @default.
- W4385652175 created "2023-08-09" @default.
- W4385652175 creator A5014705912 @default.
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- W4385652175 creator A5092617498 @default.
- W4385652175 creator A5092617499 @default.
- W4385652175 date "2023-09-01" @default.
- W4385652175 modified "2023-10-17" @default.
- W4385652175 title "Promising influences of zingerone against natural and chemical toxins: A comprehensive and mechanistic review" @default.
- W4385652175 cites W1070041259 @default.
- W4385652175 cites W1575695805 @default.
- W4385652175 cites W1600991872 @default.
- W4385652175 cites W1818515569 @default.
- W4385652175 cites W1965482322 @default.
- W4385652175 cites W1966166613 @default.
- W4385652175 cites W1977786843 @default.
- W4385652175 cites W1982523260 @default.
- W4385652175 cites W1983615230 @default.
- W4385652175 cites W2009700731 @default.
- W4385652175 cites W2010024704 @default.
- W4385652175 cites W2020857493 @default.
- W4385652175 cites W2023131277 @default.
- W4385652175 cites W2023421664 @default.
- W4385652175 cites W2046413751 @default.
- W4385652175 cites W2058443165 @default.
- W4385652175 cites W2080716292 @default.
- W4385652175 cites W2087609729 @default.
- W4385652175 cites W2089585480 @default.
- W4385652175 cites W2116207286 @default.
- W4385652175 cites W2131154326 @default.
- W4385652175 cites W2134771624 @default.
- W4385652175 cites W2151216275 @default.
- W4385652175 cites W2162542510 @default.
- W4385652175 cites W2171576776 @default.
- W4385652175 cites W2198429069 @default.
- W4385652175 cites W2220075964 @default.
- W4385652175 cites W2315334924 @default.
- W4385652175 cites W2401747082 @default.
- W4385652175 cites W2430260503 @default.
- W4385652175 cites W2464254731 @default.
- W4385652175 cites W2511338219 @default.
- W4385652175 cites W2549839544 @default.
- W4385652175 cites W2606292671 @default.
- W4385652175 cites W2614143974 @default.
- W4385652175 cites W2623246154 @default.
- W4385652175 cites W2745372765 @default.
- W4385652175 cites W2746702337 @default.
- W4385652175 cites W2752242054 @default.
- W4385652175 cites W2752507303 @default.
- W4385652175 cites W2763923120 @default.
- W4385652175 cites W2766346903 @default.
- W4385652175 cites W2769884280 @default.
- W4385652175 cites W2775451099 @default.
- W4385652175 cites W2781157943 @default.
- W4385652175 cites W2783803118 @default.
- W4385652175 cites W2792725032 @default.
- W4385652175 cites W2793707036 @default.
- W4385652175 cites W2794342961 @default.
- W4385652175 cites W2799685606 @default.
- W4385652175 cites W2802006902 @default.
- W4385652175 cites W2808728125 @default.
- W4385652175 cites W2884523004 @default.
- W4385652175 cites W2891886277 @default.
- W4385652175 cites W2900625822 @default.
- W4385652175 cites W2912376001 @default.
- W4385652175 cites W2920188966 @default.
- W4385652175 cites W2943731257 @default.
- W4385652175 cites W2948303250 @default.
- W4385652175 cites W2970479343 @default.
- W4385652175 cites W2973103197 @default.
- W4385652175 cites W2974426088 @default.
- W4385652175 cites W2982574374 @default.
- W4385652175 cites W3022439723 @default.
- W4385652175 cites W3024416765 @default.
- W4385652175 cites W3033934423 @default.
- W4385652175 cites W3044937717 @default.
- W4385652175 cites W3048945544 @default.
- W4385652175 cites W3049381934 @default.
- W4385652175 cites W3083264664 @default.
- W4385652175 cites W3084938037 @default.
- W4385652175 cites W3087308837 @default.
- W4385652175 cites W3094867835 @default.
- W4385652175 cites W3095948481 @default.
- W4385652175 cites W3097495680 @default.
- W4385652175 cites W3127789568 @default.
- W4385652175 cites W3147898397 @default.
- W4385652175 cites W3165371663 @default.
- W4385652175 cites W3169271526 @default.
- W4385652175 cites W3170632490 @default.
- W4385652175 cites W3193730885 @default.
- W4385652175 cites W3194926838 @default.
- W4385652175 cites W3216582714 @default.
- W4385652175 cites W4210676285 @default.
- W4385652175 cites W4220818343 @default.
- W4385652175 cites W4285744480 @default.
- W4385652175 cites W4300773148 @default.