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• W4385652199 abstract "The present investigation planned to study the cardiovascular worries in Rose Bengal (RB) induced thrombotic rats by analysing biochemical profile of plasma, platelet membrane and cardiac tissue. Male Wistar rats were categorized into two groups. The group I was Control (C) rats and received glucose, whereas group II was Rose Bengal (50 mg/kg) induced thrombotic rats. The animals sacrificed and biological samples collected were analysed for various biochemical parameters. In rats RB induced heart damage/thrombosis showed significantly increased levels of lipid peroxidation (LPO), nitrate and nitrite. In RB administered group the antioxidant activities were lowered significantly i.e., reduced glutathione, glutathione S-transferase, glutathione peroxidase, superoxide dismutase and catalase when compared with control rats. Plasma enzymes SGOT, SGPT were decreased and Na+-K+ ATPase was significantly increased in group II in comparison with group I. There is no significant change in plasma hexokinase enzyme in RB administered rats when compared with control rats. The non-enzymatic and enzymatic antioxidants levels were decreased significantly in experimental groups II to compare with control group I rats. A significant increase in platelet membrane fluidity observed in group II rats when compared with group I rats in DPH and pyrene employed method. A significant raise in LPO of platelet membrane was observed in the experimental rats. Plasma nitrite and nitrate levels were increased in group II when compared to group I. Furthermore, the haematological parameters were also increased in group II when compared to group I rats. This investigation pointed out that the nitric oxide scavenging levels increased and might be protected the oxidative stress and free radicals generated by RB induced cardiac thrombosis in rats." @default.
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• W4385652199 date "2023-11-01" @default.
• W4385652199 modified "2023-09-26" @default.
• W4385652199 title "Rose Bengal induced formation of thrombosis in rats and an investigation of cardiovascular worries by haematological changes" @default.
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• W4385652199 doi "https://doi.org/10.1016/j.jksus.2023.102838" @default.
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