Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385652234> ?p ?o ?g. }
- W4385652234 endingPage "113505" @default.
- W4385652234 startingPage "113505" @default.
- W4385652234 abstract "T-cell acute lymphocytic leukemia (T-ALL) is the most common cancer in children, with a low survival rate because of drug resistance and a high recurrence rate. Targeted delivery of chemotherapy drugs can reduce their side effects and improve their efficacy. The abnormality of phosphatidylinositol-3-kinase/protein kinase B/ mammalian target of rapamycin (PI3K/Akt/mTOR) pathway plays a key role in T-ALL occurrence. AZD5363 is a selective Akt inhibitor with promising therapeutic potential for tumors encoded by the PI3K/Akt/mTOR pathway. However, the toxicity and side effects have limited its application in treating T-ALL. This study aimed to design a delivery system for targeting AZD5363 to T-ALL by sgc8c aptamer designed as mesoporous silica (mSiO2) decorated with Au nanoparticles. The cell-specific targeting and cytotoxicity of mSiO2-Au-AZD5363-Apt were investigated. The mSiO2-Au nanovehicles were found feasible for AZD5363 delivery, with high loading efficiency and pH-responsive release in the acidic lysosome. More importantly, mSiO2-Au-AZD5363-Apt nanovehicles could specifically recognize and enter T-ALL cells in vitro and in vivo, effectively inhibiting the proliferation of CCRF-CEM cells. In conclusion, mSiO2-Au-AZD5363-Apt provided an effective therapeutic method for the targeted treatment of T-ALL." @default.
- W4385652234 created "2023-08-09" @default.
- W4385652234 creator A5006387641 @default.
- W4385652234 creator A5021814017 @default.
- W4385652234 creator A5032760006 @default.
- W4385652234 creator A5041227791 @default.
- W4385652234 creator A5050017616 @default.
- W4385652234 creator A5052297489 @default.
- W4385652234 creator A5060882707 @default.
- W4385652234 creator A5064317688 @default.
- W4385652234 creator A5087362907 @default.
- W4385652234 date "2023-10-01" @default.
- W4385652234 modified "2023-09-23" @default.
- W4385652234 title "Targeted delivery of AZD5363 to T-cell acute lymphocytic leukemia by mSiO2-Au nanovehicles" @default.
- W4385652234 cites W1485498775 @default.
- W4385652234 cites W1973297092 @default.
- W4385652234 cites W1974250949 @default.
- W4385652234 cites W1987305481 @default.
- W4385652234 cites W1999060596 @default.
- W4385652234 cites W2055776993 @default.
- W4385652234 cites W2056649390 @default.
- W4385652234 cites W2057386641 @default.
- W4385652234 cites W2065016533 @default.
- W4385652234 cites W2117497402 @default.
- W4385652234 cites W2129808949 @default.
- W4385652234 cites W2157782360 @default.
- W4385652234 cites W2225075140 @default.
- W4385652234 cites W2319878881 @default.
- W4385652234 cites W2498191157 @default.
- W4385652234 cites W2529608519 @default.
- W4385652234 cites W2532210198 @default.
- W4385652234 cites W2581394992 @default.
- W4385652234 cites W2589289173 @default.
- W4385652234 cites W2749830411 @default.
- W4385652234 cites W2803471959 @default.
- W4385652234 cites W2890954953 @default.
- W4385652234 cites W2897960264 @default.
- W4385652234 cites W2921167368 @default.
- W4385652234 cites W2948438687 @default.
- W4385652234 cites W2951193083 @default.
- W4385652234 cites W2971651667 @default.
- W4385652234 cites W3039100547 @default.
- W4385652234 cites W3104513873 @default.
- W4385652234 cites W3108870988 @default.
- W4385652234 cites W3119975089 @default.
- W4385652234 cites W3207973831 @default.
- W4385652234 cites W3211670204 @default.
- W4385652234 cites W4205307467 @default.
- W4385652234 cites W4221066482 @default.
- W4385652234 cites W4292820648 @default.
- W4385652234 cites W4319795659 @default.
- W4385652234 cites W4380683474 @default.
- W4385652234 doi "https://doi.org/10.1016/j.colsurfb.2023.113505" @default.
- W4385652234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37574619" @default.
- W4385652234 hasPublicationYear "2023" @default.
- W4385652234 type Work @default.
- W4385652234 citedByCount "0" @default.
- W4385652234 crossrefType "journal-article" @default.
- W4385652234 hasAuthorship W4385652234A5006387641 @default.
- W4385652234 hasAuthorship W4385652234A5021814017 @default.
- W4385652234 hasAuthorship W4385652234A5032760006 @default.
- W4385652234 hasAuthorship W4385652234A5041227791 @default.
- W4385652234 hasAuthorship W4385652234A5050017616 @default.
- W4385652234 hasAuthorship W4385652234A5052297489 @default.
- W4385652234 hasAuthorship W4385652234A5060882707 @default.
- W4385652234 hasAuthorship W4385652234A5064317688 @default.
- W4385652234 hasAuthorship W4385652234A5087362907 @default.
- W4385652234 hasBestOaLocation W43856522341 @default.
- W4385652234 hasConcept C185592680 @default.
- W4385652234 hasConcept C203014093 @default.
- W4385652234 hasConcept C2777938653 @default.
- W4385652234 hasConcept C2778461978 @default.
- W4385652234 hasConcept C502942594 @default.
- W4385652234 hasConcept C55493867 @default.
- W4385652234 hasConcept C62478195 @default.
- W4385652234 hasConcept C71924100 @default.
- W4385652234 hasConcept C75217442 @default.
- W4385652234 hasConcept C86554907 @default.
- W4385652234 hasConcept C98274493 @default.
- W4385652234 hasConceptScore W4385652234C185592680 @default.
- W4385652234 hasConceptScore W4385652234C203014093 @default.
- W4385652234 hasConceptScore W4385652234C2777938653 @default.
- W4385652234 hasConceptScore W4385652234C2778461978 @default.
- W4385652234 hasConceptScore W4385652234C502942594 @default.
- W4385652234 hasConceptScore W4385652234C55493867 @default.
- W4385652234 hasConceptScore W4385652234C62478195 @default.
- W4385652234 hasConceptScore W4385652234C71924100 @default.
- W4385652234 hasConceptScore W4385652234C75217442 @default.
- W4385652234 hasConceptScore W4385652234C86554907 @default.
- W4385652234 hasConceptScore W4385652234C98274493 @default.
- W4385652234 hasLocation W43856522341 @default.
- W4385652234 hasLocation W43856522342 @default.
- W4385652234 hasOpenAccess W4385652234 @default.
- W4385652234 hasPrimaryLocation W43856522341 @default.
- W4385652234 hasRelatedWork W1988747615 @default.
- W4385652234 hasRelatedWork W1993312761 @default.
- W4385652234 hasRelatedWork W2145454786 @default.
- W4385652234 hasRelatedWork W2912656088 @default.