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• W4385652284 startingPage "152411" @default.
• W4385652284 abstract "Major depressive disorder (MDD) and dementia are both major contributors to the global burden of disease. However, information on the bidirectional association between MDD and dementia is still lacking. Therefore, this study assessed the bidirectional associations between MDD and dementia. We conducted two population-based retrospective cohort studies in Taiwan. We identified 80,742 patients diagnosed with MDD in 2009–2010 and matched them with patients without MDD by sex, age, and year of diagnosis to assess the relative risk of dementia. We also identified 80,108 patients diagnosed with dementia in 2009–2010 and matched them with patients without dementia by sex, age, and year of diagnosis to assess the relative risk of MDD. All patients were followed until they received a diagnosis of new onset MDD or new onset dementia, their death, or the end of 2019. Cause-specific hazards models were used to estimate adjusted hazard ratios (aHRs). The incidence density (ID) of dementia was higher in patients with MDD than in patients without MDD (7.63 vs. 2.99 per 1000 person-years), with an aHR of 2.71 (95% confidence interval [CI]: 2.55–2.88). The ID of MDD was higher in patients with dementia than in patients without dementia (12.77 vs. 4.69 per 1000 person-years), with an aHR of 2.47 (95% CI: 2.35–2.59). This population-based study found a bidirectional association between MDD and dementia. Our findings suggest the need to identify dementia in patients with MDD and vice versa." @default.
• W4385652284 created "2023-08-09" @default.
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• W4385652284 date "2023-11-01" @default.
• W4385652284 modified "2023-10-18" @default.
• W4385652284 title "Bidirectional association between major depressive disorder and dementia: Two population-based cohort studies in Taiwan" @default.
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• W4385652284 doi "https://doi.org/10.1016/j.comppsych.2023.152411" @default.
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