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- W4385654823 abstract "Periprosthetic joint infections (PJI) following joint arthroplasty are now the leading cause of reoperation and are associated with serious morbidity to the patient, often requiring several staged operations and a prolonged course of parenteral antibiotics. Prophylactic administration of intravenous antibiotics before skin incision is arguably the most important measure to prevent PJI; however, the dose effectiveness of cefazolin in target tissue is not well known. We aimed to identify parameters affecting local tissue concentration (LTC) of cefazolin.We performed a literature search using the following keywords: orthopaedics, orthopedic, arthroplasty and cefazolin. We included studies that measured LTC of cefazolin from samples obtained during either a total knee or total hip arthroplasty.Of the 332 records screened, we included 10 studies that described LTC of cefazolin. The included studies evaluated dosing (n = 7), procedure type (n = 3), body mass index (n = 1) and tourniquet utilization (n = 1).Few studies have measured LTC levels of antibiotics (or levels of cefazolin) to validate current recommendations for antibiotic prophylaxis in orthopedic surgery. With infection as the leading reason for early reoperation or revision surgery, the parameters affecting LTC during orthopedic procedures need to be further assessed." @default.
- W4385654823 created "2023-08-09" @default.
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- W4385654823 date "2023-08-08" @default.
- W4385654823 modified "2023-10-18" @default.
- W4385654823 title "Local tissue concentrations of cefazolin during total joint arthroplasty: a systematic review" @default.
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- W4385654823 doi "https://doi.org/10.1503/cjs.019621" @default.
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