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• W4385655013 abstract "Topic: 16. Myeloproliferative neoplasms - Clinical Background: MF is a myeloproliferative neoplasm characterized by splenomegaly, debilitating symptoms, and bone marrow fibrosis. Transfusion-dependent (TD) anemia is present in one-quarter of patients at diagnosis and becomes more common as the disease progresses. TD imposes a high cost burden on healthcare systems with annual total medical costs up to ≈9 times higher for TD patients than for non-TD patients. MMB was assessed in previously JAK inhibitor treated, symptomatic, anemic patients with MF, ≈50% of whom were TD at entry in the phase 3 MOMENTUM trial (NCT04173494). MMB led to reduced transfusion burden compared with DAN and achieved durable transfusion independence (no red blood cell [RBC] transfusions 12 weeks prior and hemoglobin ≥8 g/dL). Aims: To estimate the projected differences in total medical service costs and time burden related to MMB vs DAN. Methods: Analysis was based on rates of TD (requiring ≥4 units of RBC transfusion in the 8 weeks before randomization), transfusion-independent (TI), transfusion-requiring (TR; requiring transfusions but did not meet the criteria for TD), and transfusion visits in MMB and DAN arms over 24 weeks from MOMENTUM. Projected cost offsets for MMB relative to DAN were calculated using these transfusion rates and cost estimates for TD vs TI/TR and transfusion visits from a previous economic analysis of patients with MF using the IBM MarketScan database (Gerds AT, et al. ASH 2022. Abstract 1729). Projected time savings were based on transfusion rates and time burden estimates for transfusion visits in patients with TD β-thalassemia (Knoth RL, et al. EHA 2022. Poster P1741). Results: Projected average annual total medical cost savings with MMB vs DAN was $53,143 per patient with baseline TD and $46,455 per patient with baseline TI/TR. Reduced rates of transfusion visits with MMB vs DAN were associated with annual outpatient transfusion cost savings of $16,520 per patient with baseline TD and $2,951 per patient with baseline TI/TR. Among patients who were TD at baseline, projected average annual savings in transfusion visit time associated with MMB vs DAN totaled 68 hours per patient (27 hours for preparation and waiting time, 32 hours for transfusion procedure and recovery, and 9 hours for travel time). Summary/Conclusion: Reductions in the rate of transfusion dependence and the number of transfusions required for MMB relative to DAN are associated with projected healthcare system cost savings in total medical and outpatient transfusion costs, and reduced projected transfusion-related time burden in these patients with MF.Keywords: Anemia, Myelofibrosis, Transfusion" @default.
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• W4385655013 date "2023-08-01" @default.
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• W4385655013 title "PB2183: TRANSFUSION-RELATED COST OFFSETS AND TIME BURDEN IN PATIENTS WITH MYELOFIBROSIS (MF) TREATED WITH MOMELOTINIB (MMB) VS DANAZOL (DAN)" @default.
• W4385655013 doi "https://doi.org/10.1097/01.hs9.0000975484.93174.12" @default.
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