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- W4385655168 abstract "Topic: 17. Hodgkin lymphoma - Clinical Background: Hodgkin’s Lymphoma (HL) has been commonly recognized as a chemo-sensitive and potentially curable neoplastic disease. However, some patients are refractory or relapse after frontline therapy, and their prognosis is severely impacted by a potential outcome predictors. Aims: This study’s aim was to identify potential predictors of worse overall survival (OS) and event free survival (EFS) in patients affected by R/R HL treated with salvage therapy. Methods: We included R/R HL patients diagnosed at the hospital of Farhat Hached Sousse, between 2014 and 2020. The impact on overall survival (OS) and on event free survival (EFS) of the following prognostic parameters was studied: age of ≥ 45 years old, extra lymphatic infiltration, presence of B symptoms, lymph node involvement >3 sites, bulky disease, serum albumin<30g/dl, advanced stage (III -IV), and chemo sensitivity at the second salvage therapeutic regimen. Survival curves were compared with Log-rank test, Cox proportional hazards test was used for multivariate analysis. Results: Of the 41 patients analyzed, 12 (29%) had early-stage and 29(71%) had advanced-stage (IIB or higher) HL. Median age was 34 years [18-67], 21 (51%) of patients were male, 23 (56%) presented with B-symptoms and 13 (31, 7%) had bulky disease. Salvage therapy was indicated for relapsed HL in 7 patients (17%), and for HL refractory to first-line CT in 34 patients (83%). After a median follow up of 48 months the 3-year OS and PFS for the whole population were 63% and 10%, respectively. In univariate analysis lymph node involvement >3 sites, B symptoms, absence of chemo sensitivity at the second salvage therapeutic regimen, were associated with a shorter OS (p<0.05), while serum albumin <30g/l and advanced age, were associated with worse EFS (p<0.05). In multivariate analysis, no prognostic factor was correlated with OS and EFS and this can be explained by the small number of our patients. Summary/Conclusion: We demonstrated that absence of chemo sensitivity at the second salvage therapeutic regimen was associated with poor OS indicating the impact of choosing the best salvage regimen to achieve promptly the complete remission. Keywords: Hodgkin’s lymphoma" @default.
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- W4385655168 date "2023-08-01" @default.
- W4385655168 modified "2023-10-14" @default.
- W4385655168 title "PB2262: PROGNOSTIC FACTORS IN PATIENTS WITH RELAPSED/REFRACTORY HODGKINN LYMPHOMA" @default.
- W4385655168 doi "https://doi.org/10.1097/01.hs9.0000975780.40115.2c" @default.
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