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- W4385655199 abstract "The Arg-Gly-Asp (RGD)-binding family of integrin receptors, and notably the β3 subfamily, are key to multiple physiological processes involved in tissue development, cancer proliferation, and metastatic dissemination. While there is compelling preclinical evidence that both αvβ3 and αIIbβ3 are important anticancer targets, most integrin antagonists developed to target the β3 integrins are highly selective for αvβ3 or αIIbβ3. We report the design, synthesis, and biological evaluation of a new structural class of ligand-mimetic β3 integrin antagonist. These new antagonists combine a high activity against αvβ3 with a moderate affinity for αIIbβ3, providing the first evidence for a new approach to integrin targeting in cancer." @default.
- W4385655199 created "2023-08-09" @default.
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- W4385655199 date "2023-08-08" @default.
- W4385655199 modified "2023-09-26" @default.
- W4385655199 title "Synthesis and Biological Evaluation of Cyclobutane-Based β3 Integrin Antagonists: A Novel Approach to Targeting Integrins for Cancer Therapy" @default.
- W4385655199 cites W1546251826 @default.
- W4385655199 cites W1576773659 @default.
- W4385655199 cites W1607041879 @default.
- W4385655199 cites W1734622341 @default.
- W4385655199 cites W1786914907 @default.
- W4385655199 cites W1867461922 @default.
- W4385655199 cites W1896287540 @default.
- W4385655199 cites W1937615586 @default.
- W4385655199 cites W1964433907 @default.
- W4385655199 cites W1968389289 @default.
- W4385655199 cites W1970040510 @default.
- W4385655199 cites W1973814270 @default.
- W4385655199 cites W1975986367 @default.
- W4385655199 cites W1979925032 @default.
- W4385655199 cites W1982016912 @default.
- W4385655199 cites W1986083736 @default.
- W4385655199 cites W1989072865 @default.
- W4385655199 cites W1991462747 @default.
- W4385655199 cites W1998353327 @default.
- W4385655199 cites W2005419086 @default.
- W4385655199 cites W2006518198 @default.
- W4385655199 cites W2008235594 @default.
- W4385655199 cites W2008609171 @default.
- W4385655199 cites W2012756282 @default.
- W4385655199 cites W2013109407 @default.
- W4385655199 cites W2015128434 @default.
- W4385655199 cites W2015950132 @default.
- W4385655199 cites W2019284238 @default.
- W4385655199 cites W2019364371 @default.
- W4385655199 cites W2020654599 @default.
- W4385655199 cites W2025702058 @default.
- W4385655199 cites W2029180789 @default.
- W4385655199 cites W2029572050 @default.
- W4385655199 cites W2029773366 @default.
- W4385655199 cites W2032908153 @default.
- W4385655199 cites W2034643383 @default.
- W4385655199 cites W2036697376 @default.
- W4385655199 cites W2037615838 @default.
- W4385655199 cites W2039496775 @default.
- W4385655199 cites W2042021259 @default.
- W4385655199 cites W2042979331 @default.
- W4385655199 cites W2046267543 @default.
- W4385655199 cites W2047987451 @default.
- W4385655199 cites W2049144739 @default.
- W4385655199 cites W2050701385 @default.
- W4385655199 cites W2051135339 @default.
- W4385655199 cites W2053415590 @default.
- W4385655199 cites W2053566469 @default.
- W4385655199 cites W2058764910 @default.
- W4385655199 cites W2058767414 @default.
- W4385655199 cites W2060872096 @default.
- W4385655199 cites W2064559081 @default.
- W4385655199 cites W2067401961 @default.
- W4385655199 cites W2067836657 @default.
- W4385655199 cites W2068046924 @default.
- W4385655199 cites W2068762259 @default.
- W4385655199 cites W2070825201 @default.
- W4385655199 cites W2074686740 @default.
- W4385655199 cites W2076341305 @default.
- W4385655199 cites W2077880808 @default.
- W4385655199 cites W2079323372 @default.
- W4385655199 cites W2079361575 @default.
- W4385655199 cites W2092036242 @default.
- W4385655199 cites W2094469836 @default.
- W4385655199 cites W2096399528 @default.
- W4385655199 cites W2101386911 @default.
- W4385655199 cites W2101922439 @default.
- W4385655199 cites W2105932257 @default.
- W4385655199 cites W2108623638 @default.
- W4385655199 cites W2111033848 @default.
- W4385655199 cites W2127292567 @default.
- W4385655199 cites W2134339160 @default.
- W4385655199 cites W2135030834 @default.
- W4385655199 cites W2136993284 @default.
- W4385655199 cites W2139981532 @default.
- W4385655199 cites W2142580186 @default.
- W4385655199 cites W2150531719 @default.
- W4385655199 cites W2153801209 @default.
- W4385655199 cites W2163188200 @default.
- W4385655199 cites W2166216036 @default.
- W4385655199 cites W2167107456 @default.
- W4385655199 cites W2171854784 @default.
- W4385655199 cites W2327877667 @default.
- W4385655199 cites W2335037156 @default.