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- W4385655221 abstract "Topic: 19. Aggressive Non-Hodgkin lymphoma - Clinical Background:Diffuse large B-cell lymphoma (DLBCL) is the most common variant of non-Hodgkin lymphomas. Approximately 60% of patients achieve complete response (CR) with the standard R-CHOP protocol. One-third of patients develop relapse or refractoriness to therapy. Existing prediction models are often ineffective so searching for additional molecular biological prognostic factors is relevant. Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane space flavoprotein with diverse functions in cellular physiology encoded by the AIFM1 (Xq25) gene. AIF plays role as an effector of the caspase-independent cell death pathway and it also involved in redox reactions. Upon the induction of apoptosis, AIF translocates from the mitochondrial intermembrane space to the nucleus and mediates DNA fragmentation. According to the literature, AIF plays an important role in the pathogenesis of hematological diseases as a proapototic protein. However, the prognostic value of AIF is still unexplored, and the results of studies are inconsistent. Aims:To assess the relationship of AIF protein expression with DLBCL prognosis. Methods:We have analyzed histological slices of formalin-fixed paraffin-embedded (FFPE) tumor tissue samples obtained from 100 patients with newly diagnosed DLBCL. The median age was 58 years. All patients received first-line treatment with R-CHOP regimen. The assessment of the relative number of AIF-positive tumor cells was performed using immunohistochemical and morphometric methods. The median expression of AIF was 60%. According to ROC-analysis threshold value set to 57% AIF-postive tumor cells. All subjects were divided into groups with high (≥57%) and low (<57%) protein expression. The relationship of AIF expression with prognosis in DLBCL was analyzed using univariate Cox regression analysis. Results:AIF expression was detected in 97 out of 100 patients. In 57 subjects, protein expression was found to be above the threshold level, in 43 cases - below the threshold. Low expression of the marker was associated with the lack of a complete response to treatment with R-CHOP regimen (p=0.048), as with III-IV disease stages (p=0.04), higher than normal total serum lactate dehydrogenase (LDH) concentration (p=0.039), IPI ˃2 points (p=0.010). In the studied cohort of patients, with a decrease in the proportion of AIF-positive tumor cells, the risk of an earlier onset of death increased (p=0.04; HR=0.8; 95% CI=0.96-0.99). Summary/Conclusion:A low AIF level is associated with poor clinical diagnostic parameters and a high risk of death in patients with DLBCL. Keywords: Hematological malignancy, B cell, B cell lymphoma, Diffuse large B cell lymphoma" @default.
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- W4385655221 date "2023-08-01" @default.
- W4385655221 modified "2023-09-27" @default.
- W4385655221 title "PB2313: THE PROGNOSTIC SIGNIFICANCE OF APOPTOSIS-INDUCING FACTOR IN DIFFUSE LARGE B-CELL LYMPHOMA" @default.
- W4385655221 doi "https://doi.org/10.1097/01.hs9.0000975976.12640.36" @default.
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