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• W4385655234 endingPage "23.2023" @default.
• W4385655234 startingPage "ENEURO.0206" @default.
• W4385655234 abstract "Abstract In mammals several memory systems are responsible for learning and storage of associative memory. Even apparently simple behavioral tasks, like pavlovian conditioning, have been suggested to engage, for instance, implicit and explicit memory processes. Here, we used single-whisker tactile trace eyeblink conditioning (TTEBC) to investigate learning and its neuronal bases in the mouse barrel column, the primary neocortical tactile representation of one whisker. Behavioral analysis showed that conditioned responses (CRs) are spatially highly restricted; they generalize from the principal whisker only to its direct neighbors. Within the respective neural representation, the principal column and its direct neighbors, spike activity showed a learning-related spike rate suppression starting during the late phase of conditioning stimulus (CS) presentation that was sustained throughout the stimulus-free trace period (Trace). Trial-by-trial analysis showed that learning-related activity was independent from the generation of eyelid movements within a trial, and set in around the steepest part of the learning curve. Optogenetic silencing of responses and their learning-related changes during CS and Trace epochs blocked CR acquisition but not its recall after learning. Silencing during the Trace alone, which carried major parts of the learning-related changes, had no effect. In summary, we demonstrate specific barrel column spike rate plasticity during TTEBC that can be partially decoupled from the CR, the learned eye closure, a hallmark of implicit learning. Our results, thus, point to a possible role of the barrel column in contributing to other kinds of memory as well." @default.
• W4385655234 created "2023-08-09" @default.
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• W4385655234 date "2023-08-01" @default.
• W4385655234 modified "2023-09-25" @default.
• W4385655234 title "ACTIVITY IN BARREL CORTEX RELATED TO TRACE EYEBLINK CONDITIONING" @default.
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• W4385655234 doi "https://doi.org/10.1523/eneuro.0206-23.2023" @default.
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