FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385655329> ?p ?o ?g. }

• W4385655329 endingPage "e0289642" @default.
• W4385655329 startingPage "e0289642" @default.
• W4385655329 abstract "Among individuals with sickle cell disease (SCD), decreased hemoglobin is associated with lower oxygen saturation (SpO2) and increased risk of stroke, both of which are associated with lower intelligence quotient (IQ) scores. Thus, increasing hemoglobin and SpO2 in individuals with SCD may increase IQ and educational attainment.A cohort simulation model was built to determine academic performance and educational attainment based on cognitive function (measured by IQ) of a pediatric SCD cohort randomly assigned to treatment and control groups. The model contained two key stages: childhood (<10 years) and adolescence (≥10 years). In stage 1, increased hemoglobin and increased SpO2 (assigned to the treatment group) were determinants of higher IQ, prevention of IQ deterioration over time. Increased hemoglobin was also a determinant of decreased stroke risk. In stage 2, improvement in adolescent IQ as a result of treatment was a determinant of academic performance.In a simulated cohort of 2000 children and adolescents with SCD (52.5% female, 50% treated), stroke incidence was predicted to be 44.4% lower among the treated group than the untreated group (4.5% versus 8.1%, respectively). The average IQ among the treated group was estimated to be 91.1 compared with 82.9 in the untreated group (a 9.9% difference; P<0.001). Finally, high school (≥12 years of education) completion rates were estimated to be 64.7% higher among the treated group: 76.1% of the treated group was projected to complete high school compared with 46.2% of the untreated group.Our model predicts that an average improvement in hemoglobin of 1.1 g/dL (11 g/L) among individuals with SCD may be associated with improved neurocognition and educational outcomes. These improvements may also generate benefits not captured by our model, including improved quality of life, employment, and income." @default.
• W4385655329 created "2023-08-09" @default.
• W4385655329 creator A5011744385 @default.
• W4385655329 creator A5019591592 @default.
• W4385655329 creator A5028511278 @default.
• W4385655329 creator A5035755501 @default.
• W4385655329 creator A5062030862 @default.
• W4385655329 creator A5085127544 @default.
• W4385655329 date "2023-08-08" @default.
• W4385655329 modified "2023-09-23" @default.
• W4385655329 title "Cognition and education benefits of increased hemoglobin and blood oxygenation in children with sickle cell disease" @default.
• W4385655329 cites W1587728123 @default.
• W4385655329 cites W1597151660 @default.
• W4385655329 cites W2012008586 @default.
• W4385655329 cites W2039327271 @default.
• W4385655329 cites W2039678166 @default.
• W4385655329 cites W2047536201 @default.
• W4385655329 cites W2050999880 @default.
• W4385655329 cites W2054903745 @default.
• W4385655329 cites W2060753739 @default.
• W4385655329 cites W2078789198 @default.
• W4385655329 cites W2091136650 @default.
• W4385655329 cites W2094513350 @default.
• W4385655329 cites W2094967472 @default.
• W4385655329 cites W2097900309 @default.
• W4385655329 cites W2104962793 @default.
• W4385655329 cites W2106568107 @default.
• W4385655329 cites W2129833599 @default.
• W4385655329 cites W2134205173 @default.
• W4385655329 cites W2152692526 @default.
• W4385655329 cites W2165905534 @default.
• W4385655329 cites W2315155986 @default.
• W4385655329 cites W2334263927 @default.
• W4385655329 cites W2557104988 @default.
• W4385655329 cites W2800998817 @default.
• W4385655329 cites W2951288545 @default.
• W4385655329 cites W2953900489 @default.
• W4385655329 cites W2955911268 @default.
• W4385655329 cites W2979450238 @default.
• W4385655329 cites W2989303083 @default.
• W4385655329 cites W3107081749 @default.
• W4385655329 cites W3122844462 @default.
• W4385655329 cites W3125358341 @default.
• W4385655329 cites W3132104838 @default.
• W4385655329 cites W3135854397 @default.
• W4385655329 cites W3141197395 @default.
• W4385655329 cites W3210066898 @default.
• W4385655329 cites W4200444558 @default.
• W4385655329 doi "https://doi.org/10.1371/journal.pone.0289642" @default.
• W4385655329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37552696" @default.
• W4385655329 hasPublicationYear "2023" @default.
• W4385655329 type Work @default.
• W4385655329 citedByCount "0" @default.
• W4385655329 crossrefType "journal-article" @default.
• W4385655329 hasAuthorship W4385655329A5011744385 @default.
• W4385655329 hasAuthorship W4385655329A5019591592 @default.
• W4385655329 hasAuthorship W4385655329A5028511278 @default.
• W4385655329 hasAuthorship W4385655329A5035755501 @default.
• W4385655329 hasAuthorship W4385655329A5062030862 @default.
• W4385655329 hasAuthorship W4385655329A5085127544 @default.
• W4385655329 hasBestOaLocation W43856553291 @default.
• W4385655329 hasConcept C118552586 @default.
• W4385655329 hasConcept C120665830 @default.
• W4385655329 hasConcept C121332964 @default.
• W4385655329 hasConcept C126322002 @default.
• W4385655329 hasConcept C127413603 @default.
• W4385655329 hasConcept C166047926 @default.
• W4385655329 hasConcept C169900460 @default.
• W4385655329 hasConcept C187212893 @default.
• W4385655329 hasConcept C201903717 @default.
• W4385655329 hasConcept C2778917026 @default.
• W4385655329 hasConcept C2780645631 @default.
• W4385655329 hasConcept C61511704 @default.
• W4385655329 hasConcept C71924100 @default.
• W4385655329 hasConcept C72563966 @default.
• W4385655329 hasConcept C78519656 @default.
• W4385655329 hasConceptScore W4385655329C118552586 @default.
• W4385655329 hasConceptScore W4385655329C120665830 @default.
• W4385655329 hasConceptScore W4385655329C121332964 @default.
• W4385655329 hasConceptScore W4385655329C126322002 @default.
• W4385655329 hasConceptScore W4385655329C127413603 @default.
• W4385655329 hasConceptScore W4385655329C166047926 @default.
• W4385655329 hasConceptScore W4385655329C169900460 @default.
• W4385655329 hasConceptScore W4385655329C187212893 @default.
• W4385655329 hasConceptScore W4385655329C201903717 @default.
• W4385655329 hasConceptScore W4385655329C2778917026 @default.
• W4385655329 hasConceptScore W4385655329C2780645631 @default.
• W4385655329 hasConceptScore W4385655329C61511704 @default.
• W4385655329 hasConceptScore W4385655329C71924100 @default.
• W4385655329 hasConceptScore W4385655329C72563966 @default.
• W4385655329 hasConceptScore W4385655329C78519656 @default.
• W4385655329 hasIssue "8" @default.
• W4385655329 hasLocation W43856553291 @default.
• W4385655329 hasLocation W43856553292 @default.
• W4385655329 hasOpenAccess W4385655329 @default.
• W4385655329 hasPrimaryLocation W43856553291 @default.
• W4385655329 hasRelatedWork W1980275360 @default.
• W4385655329 hasRelatedWork W2098948610 @default.

• next