FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385655391> ?p ?o ?g. }

• W4385655391 endingPage "e0289798" @default.
• W4385655391 startingPage "e0289798" @default.
• W4385655391 abstract "Liver transplantation is the most effective treatment option for patients with acute or chronic liver failure. However, the applicability and effectiveness of this modality are often limited by a shortage of donors, surgical complications, high medical costs, and the need for continuing immunosuppressive therapy. An alternative approach is liver cell transplantation. LIGHT (a member of the tumor necrosis factor superfamily) could be a promising candidate for promoting the differentiation of human bone marrow-derived mesenchymal stem cells (hBM-MSCs) into hepatocyte-like cells. In this study, we investigated the effect of LIGHT on hBM-MSC differentiation into hepatocyte-like cells. Our previous results showed that LIGHT receptor lymphotoxin-β receptor (LTβR) is constitutively expressed on the surface of hBM-MSCs. Upon treatment with recombinant human LIGHT (rhLIGHT), the phenotype of hBM-MSCs changed to round or polygonal cells. In addition, the cells exhibited high levels of hepatocyte-specific markers, including albumin, cytokeratin-18 (CK-18), CK-19, cytochrome P450 family 1 subfamily A member 1 (CYP1A1), CYP1A2, CYP3A4, SRY-box transcription factor 17 (SOX17), and forkhead box A2 (FOXA2). These results indicate that rhLIGHT enhances the differentiation of hBM-MSCs into functional hepatocyte-like cells. Furthermore, rhLIGHT-induced hepatocyte-like cells showed a higher ability to store glycogen and uptake indocyanine green compared with control cells, indicating functional progression. Additionally, treatment with rhLIGHT increased the number, viability, and proliferation of cells by inducing the S/G2/M phase and upregulating the expression of various cyclin and cyclin dependent kinase (CDK) proteins. We also found that the hepatogenic differentiation of hBM-MSCs induced by rhLIGHT was mediated by the activation of signal transducer and activator of transcription 3 (STAT3) and STAT5 pathways. Overall, our findings suggest that LIGHT plays an essential role in promoting the hepatogenic differentiation of hBM-MSCs. Hence, LIGHT may be a valuable factor for stem cell therapy." @default.
• W4385655391 created "2023-08-09" @default.
• W4385655391 creator A5001506531 @default.
• W4385655391 creator A5016149734 @default.
• W4385655391 creator A5023291463 @default.
• W4385655391 creator A5025963280 @default.
• W4385655391 creator A5028745234 @default.
• W4385655391 creator A5030217426 @default.
• W4385655391 creator A5032079722 @default.
• W4385655391 creator A5038188064 @default.
• W4385655391 creator A5048710022 @default.
• W4385655391 creator A5060579405 @default.
• W4385655391 creator A5079415337 @default.
• W4385655391 date "2023-08-08" @default.
• W4385655391 modified "2023-09-24" @default.
• W4385655391 title "LIGHT (TNFSF14) promotes the differentiation of human bone marrow-derived mesenchymal stem cells into functional hepatocyte-like cells" @default.
• W4385655391 cites W1577519659 @default.
• W4385655391 cites W1669027738 @default.
• W4385655391 cites W1706150252 @default.
• W4385655391 cites W1979043688 @default.
• W4385655391 cites W1994586809 @default.
• W4385655391 cites W2000097208 @default.
• W4385655391 cites W2021688965 @default.
• W4385655391 cites W2025942763 @default.
• W4385655391 cites W2030920153 @default.
• W4385655391 cites W2032554019 @default.
• W4385655391 cites W2045306753 @default.
• W4385655391 cites W2047998363 @default.
• W4385655391 cites W2075404044 @default.
• W4385655391 cites W2078309830 @default.
• W4385655391 cites W2085326091 @default.
• W4385655391 cites W2090563155 @default.
• W4385655391 cites W2103361668 @default.
• W4385655391 cites W2104713293 @default.
• W4385655391 cites W2107503723 @default.
• W4385655391 cites W2108881298 @default.
• W4385655391 cites W2110495955 @default.
• W4385655391 cites W2126134953 @default.
• W4385655391 cites W2128917073 @default.
• W4385655391 cites W2130012132 @default.
• W4385655391 cites W2130196278 @default.
• W4385655391 cites W2137571679 @default.
• W4385655391 cites W2142479726 @default.
• W4385655391 cites W2150151304 @default.
• W4385655391 cites W2159999899 @default.
• W4385655391 cites W2165910525 @default.
• W4385655391 cites W2482346953 @default.
• W4385655391 cites W2555587221 @default.
• W4385655391 cites W2606209221 @default.
• W4385655391 cites W2767301558 @default.
• W4385655391 cites W2769051158 @default.
• W4385655391 cites W2770195502 @default.
• W4385655391 cites W2889328060 @default.
• W4385655391 cites W2910329543 @default.
• W4385655391 cites W2943710509 @default.
• W4385655391 cites W2968810602 @default.
• W4385655391 cites W2996750322 @default.
• W4385655391 cites W2998986431 @default.
• W4385655391 cites W3022505998 @default.
• W4385655391 cites W3133460652 @default.
• W4385655391 cites W3216140833 @default.
• W4385655391 cites W4220708949 @default.
• W4385655391 cites W4255712601 @default.
• W4385655391 doi "https://doi.org/10.1371/journal.pone.0289798" @default.
• W4385655391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37552689" @default.
• W4385655391 hasPublicationYear "2023" @default.
• W4385655391 type Work @default.
• W4385655391 citedByCount "0" @default.
• W4385655391 crossrefType "journal-article" @default.
• W4385655391 hasAuthorship W4385655391A5001506531 @default.
• W4385655391 hasAuthorship W4385655391A5016149734 @default.
• W4385655391 hasAuthorship W4385655391A5023291463 @default.
• W4385655391 hasAuthorship W4385655391A5025963280 @default.
• W4385655391 hasAuthorship W4385655391A5028745234 @default.
• W4385655391 hasAuthorship W4385655391A5030217426 @default.
• W4385655391 hasAuthorship W4385655391A5032079722 @default.
• W4385655391 hasAuthorship W4385655391A5038188064 @default.
• W4385655391 hasAuthorship W4385655391A5048710022 @default.
• W4385655391 hasAuthorship W4385655391A5060579405 @default.
• W4385655391 hasAuthorship W4385655391A5079415337 @default.
• W4385655391 hasBestOaLocation W43856553911 @default.
• W4385655391 hasConcept C104317684 @default.
• W4385655391 hasConcept C148738053 @default.
• W4385655391 hasConcept C198826908 @default.
• W4385655391 hasConcept C202751555 @default.
• W4385655391 hasConcept C203014093 @default.
• W4385655391 hasConcept C2776200302 @default.
• W4385655391 hasConcept C28328180 @default.
• W4385655391 hasConcept C502942594 @default.
• W4385655391 hasConcept C55493867 @default.
• W4385655391 hasConcept C86803240 @default.
• W4385655391 hasConcept C95444343 @default.
• W4385655391 hasConceptScore W4385655391C104317684 @default.
• W4385655391 hasConceptScore W4385655391C148738053 @default.
• W4385655391 hasConceptScore W4385655391C198826908 @default.
• W4385655391 hasConceptScore W4385655391C202751555 @default.
• W4385655391 hasConceptScore W4385655391C203014093 @default.
• W4385655391 hasConceptScore W4385655391C2776200302 @default.

• next