Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385655395> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W4385655395 abstract "Abstract Background and Aims: The newly proposed nomenclature for steatotic liver diseases (SLD) aims to reduce the stigma associated with “non-alcoholic fatty liver disease” (NAFLD), increase awareness, and provide a framework for delineating pathogenic pathways. Approach and Results: We projected the new nomenclature’s diagnostic scheme onto National Health and Nutrition Examination Survey (NHANES) data and determined SLD prevalence, fibrosis risk factors, subtypes, and consistency with previous classifications. Steatosis grade and fibrosis stage were estimated from vibration controlled transient elastography (VCTE). At a threshold of 240 dB/m, 62.1% [95% confidence interval (CI), 59.8-64.3%] of adults (≥ 20 years) and 30.5% (95% CI, 27.1-34.0%) of adolescents (12-19 years) had SLD. By American Gastroenterological Association criteria, 19.3 million (95% CI, 15.8-22.8) adults with SLD qualify for hepatology referral. Over 98% of adults but only 85% of adolescents with NAFLD met criteria for definite MASLD. Significant fibrosis (≥ 8.6 kPa) occurred in 13.5 million (95% CI, 10.9-16.2) adults with MASLD; risk factors varied by race and ethnicity. Significant fibrosis occurred in over 1.5 million adults without any identified LD and was associated with lead (Pb) exposure, odds ratio = 3.89 (95% CI, 2.00-7.56). Conclusions: The overarching term, SLD, changes the diagnostic algorithm and creates an umbrella classification that highlights the extraordinary prevalence of liver steatosis. The more precise nomenclature establishes a valuable patient-centric platform for research and clinical care, clarifying risk groups and risk factors, including adolescents with NAFLD but without definite MASLD and adults without SLD in whom toxic exposures may increase fibrosis risk." @default.
- W4385655395 created "2023-08-09" @default.
- W4385655395 creator A5010225017 @default.
- W4385655395 creator A5017467301 @default.
- W4385655395 creator A5019999670 @default.
- W4385655395 creator A5056746517 @default.
- W4385655395 date "2023-08-08" @default.
- W4385655395 modified "2023-09-25" @default.
- W4385655395 title "Much more than a name change: Impact of the new steatotic liver disease nomenclature on clinical algorithms and disease classification in U.S. adults and adolescents" @default.
- W4385655395 cites W1984650281 @default.
- W4385655395 cites W2580009538 @default.
- W4385655395 cites W2606076165 @default.
- W4385655395 cites W2621001934 @default.
- W4385655395 cites W2770591742 @default.
- W4385655395 cites W2791182333 @default.
- W4385655395 cites W2800483138 @default.
- W4385655395 cites W2947374360 @default.
- W4385655395 cites W3040651296 @default.
- W4385655395 cites W3196800883 @default.
- W4385655395 cites W4225264633 @default.
- W4385655395 cites W4319320492 @default.
- W4385655395 cites W4376651668 @default.
- W4385655395 cites W4381681857 @default.
- W4385655395 doi "https://doi.org/10.1101/2023.08.04.23293664" @default.
- W4385655395 hasPublicationYear "2023" @default.
- W4385655395 type Work @default.
- W4385655395 citedByCount "0" @default.
- W4385655395 crossrefType "posted-content" @default.
- W4385655395 hasAuthorship W4385655395A5010225017 @default.
- W4385655395 hasAuthorship W4385655395A5017467301 @default.
- W4385655395 hasAuthorship W4385655395A5019999670 @default.
- W4385655395 hasAuthorship W4385655395A5056746517 @default.
- W4385655395 hasBestOaLocation W43856553951 @default.
- W4385655395 hasConcept C11413529 @default.
- W4385655395 hasConcept C126322002 @default.
- W4385655395 hasConcept C156957248 @default.
- W4385655395 hasConcept C2776135927 @default.
- W4385655395 hasConcept C2776175330 @default.
- W4385655395 hasConcept C2776954865 @default.
- W4385655395 hasConcept C2778772119 @default.
- W4385655395 hasConcept C2779134260 @default.
- W4385655395 hasConcept C2779874844 @default.
- W4385655395 hasConcept C2780559512 @default.
- W4385655395 hasConcept C2780826214 @default.
- W4385655395 hasConcept C2908647359 @default.
- W4385655395 hasConcept C2994217296 @default.
- W4385655395 hasConcept C41008148 @default.
- W4385655395 hasConcept C41260117 @default.
- W4385655395 hasConcept C44249647 @default.
- W4385655395 hasConcept C512399662 @default.
- W4385655395 hasConcept C71924100 @default.
- W4385655395 hasConcept C90924648 @default.
- W4385655395 hasConcept C99454951 @default.
- W4385655395 hasConceptScore W4385655395C11413529 @default.
- W4385655395 hasConceptScore W4385655395C126322002 @default.
- W4385655395 hasConceptScore W4385655395C156957248 @default.
- W4385655395 hasConceptScore W4385655395C2776135927 @default.
- W4385655395 hasConceptScore W4385655395C2776175330 @default.
- W4385655395 hasConceptScore W4385655395C2776954865 @default.
- W4385655395 hasConceptScore W4385655395C2778772119 @default.
- W4385655395 hasConceptScore W4385655395C2779134260 @default.
- W4385655395 hasConceptScore W4385655395C2779874844 @default.
- W4385655395 hasConceptScore W4385655395C2780559512 @default.
- W4385655395 hasConceptScore W4385655395C2780826214 @default.
- W4385655395 hasConceptScore W4385655395C2908647359 @default.
- W4385655395 hasConceptScore W4385655395C2994217296 @default.
- W4385655395 hasConceptScore W4385655395C41008148 @default.
- W4385655395 hasConceptScore W4385655395C41260117 @default.
- W4385655395 hasConceptScore W4385655395C44249647 @default.
- W4385655395 hasConceptScore W4385655395C512399662 @default.
- W4385655395 hasConceptScore W4385655395C71924100 @default.
- W4385655395 hasConceptScore W4385655395C90924648 @default.
- W4385655395 hasConceptScore W4385655395C99454951 @default.
- W4385655395 hasLocation W43856553951 @default.
- W4385655395 hasOpenAccess W4385655395 @default.
- W4385655395 hasPrimaryLocation W43856553951 @default.
- W4385655395 hasRelatedWork W2000647754 @default.
- W4385655395 hasRelatedWork W2093272464 @default.
- W4385655395 hasRelatedWork W2299390772 @default.
- W4385655395 hasRelatedWork W2333604368 @default.
- W4385655395 hasRelatedWork W2398103966 @default.
- W4385655395 hasRelatedWork W2509438375 @default.
- W4385655395 hasRelatedWork W2586781733 @default.
- W4385655395 hasRelatedWork W2920351734 @default.
- W4385655395 hasRelatedWork W2945890717 @default.
- W4385655395 hasRelatedWork W2947130828 @default.
- W4385655395 isParatext "false" @default.
- W4385655395 isRetracted "false" @default.
- W4385655395 workType "article" @default.