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- W4385658522 endingPage "2093" @default.
- W4385658522 startingPage "2093" @default.
- W4385658522 abstract "Peptides and proteins, two important classes of biomacromolecules, play important roles in the biopharmaceuticals field. As compared with traditional drugs based on small molecules, peptide- and protein-based drugs offer several advantages, although most cannot traverse the cell membrane, a natural barrier that prevents biomacromolecules from directly entering cells. However, drug delivery via cell-penetrating peptides (CPPs) is increasingly replacing traditional approaches that mediate biomacromolecular cellular uptake, due to CPPs’ superior safety and efficiency as drug delivery vehicles. In this review, we describe the discovery of CPPs, recent developments in CPP design, and recent advances in CPP applications for enhanced cellular delivery of peptide- and protein-based drugs. First, we discuss the discovery of natural CPPs in snake, bee, and spider venom. Second, we describe several synthetic types of CPPs, such as cyclic CPPs, glycosylated CPPs, and D-form CPPs. Finally, we summarize and discuss cell membrane permeability characteristics and therapeutic applications of different CPPs when used as vehicles to deliver peptides and proteins to cells, as assessed using various preclinical disease models. Ultimately, this review provides an overview of recent advances in CPP development with relevance to applications related to the therapeutic delivery of biomacromolecular drugs to alleviate diverse diseases." @default.
- W4385658522 created "2023-08-09" @default.
- W4385658522 creator A5003047051 @default.
- W4385658522 creator A5017468827 @default.
- W4385658522 creator A5019974153 @default.
- W4385658522 creator A5032300255 @default.
- W4385658522 creator A5033523107 @default.
- W4385658522 creator A5050781711 @default.
- W4385658522 creator A5079576759 @default.
- W4385658522 date "2023-08-07" @default.
- W4385658522 modified "2023-10-18" @default.
- W4385658522 title "Recent Advances of Cell-Penetrating Peptides and Their Application as Vectors for Delivery of Peptide and Protein-Based Cargo Molecules" @default.
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