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• W4385660332 abstract "<b><i>Objectives:</i></b> The aims of the study were to compare the consumption of blood products before and after the implementation of a bleeding management algorithm in patients undergoing liver transplantation and to determine the feasibility of a multicentre, randomized study. <b><i>Background:</i></b> Liver transplantation remains the only curative therapy for patients with end-stage liver disease, but it carries a high risk of surgical bleeding. <b><i>Materials and Methods:</i></b> Retrospective study of patients treated before (group 1) and after (group 2) implementation of a haemostatic algorithm guided by viscoelastic testing, including use of lyophilized coagulation factor concentrates (<i>prothrombin complex and fibrinogen concentrates</i>). Primary outcome was the number of units of blood products transfused in 24 h after surgery. Secondary outcomes included hospital stay, mortality, and cost. <b><i>Results:</i></b> Data from 30 consecutive patients was analysed; 14 in group 1 and 16 in group 2. Baseline data were similar between groups. Median total blood product consumption 24 h after surgery was 33 U (IQR: 11–57) in group 1 and 1.5 (0–23.5) in group 2 (<i>p</i> = 0.028). Significantly fewer units of red blood cells, fresh frozen plasma, and cryoprecipitate were transfused in group 2 versus group 1. There was no significant difference in complications, hospital stay, or in-hospital mortality between groups. The cost of haemostatic therapy was non-significantly lower in group 2 versus group 1 (7,400 vs. 15,500 USD; <i>p</i> = 0.454). <b><i>Conclusion:</i></b> The haemostatic management algorithm was associated with a significant reduction in blood product use during 24 h after liver transplantation. This study demonstrated the feasibility and provided a sample size calculation for a larger, randomized study." @default.
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• W4385660332 date "2023-08-03" @default.
• W4385660332 modified "2023-09-27" @default.
• W4385660332 title "Implementation of a Bleeding Management Algorithm in Liver Transplantation: A Pilot Study" @default.
• W4385660332 doi "https://doi.org/10.1159/000530579" @default.
• W4385660332 hasPublicationYear "2023" @default.
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