FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385664512> ?p ?o ?g. }

• W4385664512 abstract "Degradation of the endothelial glycocalyx is critical for sepsis-associated lung injury and pulmonary vascular permeability. We investigated whether sulodexide, a precursor for the synthesis of glycosaminoglycans, plays a biological role in glycocalyx remodeling and improves endothelial barrier dysfunction in sepsis.The number of children with septic shock that were admitted to the PICU at Children's Hospital of Fudan University who enrolled in the study was 28. On days one and three after enrollment, venous blood samples were collected, and heparan sulfate, and syndecan-1 (SDC1) were assayed in the plasma. We established a cell model of glycocalyx shedding by heparinase III and induced sepsis in a mouse model via lipopolysaccharide (LPS) injection and cecal ligation and puncture (CLP). Sulodexide was administrated to prevent endothelial glycocalyx damage. Endothelial barrier function and expression of endothelial-related proteins were determined using permeability, western blot and immunofluorescent staining. The survival rate, histopathology evaluation of lungs and wet-to-dry lung weight ratio were also evaluated.We found that circulating SDC1 levels were persistently upregulated in the non-alive group on days 1 and 3 and were positively correlated with IL-6 levels. Receiver operating characteristic curve analysis showed that SDC1 could distinguish patients with mortality. We showed that SDC1-shedding caused endothelial permeability in the presence of heparinase III and sepsis conditions. Mechanistically, sulodexide (30 LSU/mL) administration markedly inhibited SDC1 shedding and prevented endothelial permeability with zonula occludens-1 (ZO-1) upregulation via NF-κB/ZO-1 pathway. In mice with LPS and CLP-induced sepsis, sulodexide (40 mg/kg) administration decreased the plasma levels of SDC1 and increased survival rate. Additionally, sulodexide alleviated lung injury and restored endothelial glycocalyx damage.In conclusion, our data suggest that SDC1 predicts prognosis in children with septic shock and sulodexide may have therapeutic potential for the treatment of sepsis-associated endothelial dysfunction." @default.
• W4385664512 created "2023-08-09" @default.
• W4385664512 creator A5000894411 @default.
• W4385664512 creator A5012428737 @default.
• W4385664512 creator A5024671936 @default.
• W4385664512 creator A5049410725 @default.
• W4385664512 creator A5069669016 @default.
• W4385664512 creator A5072129534 @default.
• W4385664512 creator A5074660144 @default.
• W4385664512 creator A5085506535 @default.
• W4385664512 creator A5088551712 @default.
• W4385664512 date "2023-08-08" @default.
• W4385664512 modified "2023-09-26" @default.
• W4385664512 title "Sulodexide improves vascular permeability via glycocalyx remodelling in endothelial cells during sepsis" @default.
• W4385664512 cites W1520791459 @default.
• W4385664512 cites W1600560134 @default.
• W4385664512 cites W1965520866 @default.
• W4385664512 cites W1969319463 @default.
• W4385664512 cites W1976913138 @default.
• W4385664512 cites W1977877980 @default.
• W4385664512 cites W1991448459 @default.
• W4385664512 cites W2020613436 @default.
• W4385664512 cites W2023945291 @default.
• W4385664512 cites W2044960103 @default.
• W4385664512 cites W2054512362 @default.
• W4385664512 cites W2063139027 @default.
• W4385664512 cites W2076590961 @default.
• W4385664512 cites W2088505684 @default.
• W4385664512 cites W2094387772 @default.
• W4385664512 cites W2099198212 @default.
• W4385664512 cites W2104052152 @default.
• W4385664512 cites W2111766323 @default.
• W4385664512 cites W2133617398 @default.
• W4385664512 cites W2141071568 @default.
• W4385664512 cites W2141755842 @default.
• W4385664512 cites W2147617210 @default.
• W4385664512 cites W2152252241 @default.
• W4385664512 cites W2162979958 @default.
• W4385664512 cites W2255691977 @default.
• W4385664512 cites W2258210606 @default.
• W4385664512 cites W2282181907 @default.
• W4385664512 cites W2289813931 @default.
• W4385664512 cites W2418886021 @default.
• W4385664512 cites W2467845800 @default.
• W4385664512 cites W2486900556 @default.
• W4385664512 cites W2557726663 @default.
• W4385664512 cites W2581605534 @default.
• W4385664512 cites W2586856403 @default.
• W4385664512 cites W2620241325 @default.
• W4385664512 cites W2706320477 @default.
• W4385664512 cites W2900417452 @default.
• W4385664512 cites W2905635461 @default.
• W4385664512 cites W2911965925 @default.
• W4385664512 cites W2915852744 @default.
• W4385664512 cites W2944902010 @default.
• W4385664512 cites W2972199680 @default.
• W4385664512 cites W2997769624 @default.
• W4385664512 cites W2998853022 @default.
• W4385664512 cites W3005066209 @default.
• W4385664512 cites W3013230421 @default.
• W4385664512 cites W3113591723 @default.
• W4385664512 cites W3123700933 @default.
• W4385664512 cites W3137043393 @default.
• W4385664512 cites W3145440008 @default.
• W4385664512 cites W3210220807 @default.
• W4385664512 doi "https://doi.org/10.3389/fimmu.2023.1172892" @default.
• W4385664512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37614234" @default.
• W4385664512 hasPublicationYear "2023" @default.
• W4385664512 type Work @default.
• W4385664512 citedByCount "0" @default.
• W4385664512 crossrefType "journal-article" @default.
• W4385664512 hasAuthorship W4385664512A5000894411 @default.
• W4385664512 hasAuthorship W4385664512A5012428737 @default.
• W4385664512 hasAuthorship W4385664512A5024671936 @default.
• W4385664512 hasAuthorship W4385664512A5049410725 @default.
• W4385664512 hasAuthorship W4385664512A5069669016 @default.
• W4385664512 hasAuthorship W4385664512A5072129534 @default.
• W4385664512 hasAuthorship W4385664512A5074660144 @default.
• W4385664512 hasAuthorship W4385664512A5085506535 @default.
• W4385664512 hasAuthorship W4385664512A5088551712 @default.
• W4385664512 hasBestOaLocation W43856645121 @default.
• W4385664512 hasConcept C104317684 @default.
• W4385664512 hasConcept C113045295 @default.
• W4385664512 hasConcept C123012128 @default.
• W4385664512 hasConcept C126322002 @default.
• W4385664512 hasConcept C127561419 @default.
• W4385664512 hasConcept C1491633281 @default.
• W4385664512 hasConcept C185592680 @default.
• W4385664512 hasConcept C202751555 @default.
• W4385664512 hasConcept C203014093 @default.
• W4385664512 hasConcept C2778384902 @default.
• W4385664512 hasConcept C2778754761 @default.
• W4385664512 hasConcept C2780098789 @default.
• W4385664512 hasConcept C51911345 @default.
• W4385664512 hasConcept C55493867 @default.
• W4385664512 hasConcept C65001120 @default.
• W4385664512 hasConcept C71924100 @default.
• W4385664512 hasConcept C86803240 @default.
• W4385664512 hasConcept C95444343 @default.
• W4385664512 hasConceptScore W4385664512C104317684 @default.

• next