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- W4385664908 abstract "During apoptosis, caspases degrade 8 out of ∼30 nucleoporins to irreversibly demolish the nuclear pore complex. However, for poorly understood reasons, caspases are also activated during cell differentiation. Here, we show that sublethal activation of caspases during myogenesis results in the transient proteolysis of four peripheral Nups and one transmembrane Nup. “Trimmed” NPCs become nuclear export-defective, and we identified in an unbiased manner several classes of cytoplasmic, plasma-membrane, and mitochondrial proteins that rapidly accumulate in the nucleus. NPC trimming by non-apoptotic caspases was also observed in neurogenesis and endoplasmic reticulum stress. Our results suggest that caspases can reversibly modulate nuclear transport activity, which allows them to function as agents of cell differentiation and adaptation at sublethal levels." @default.
- W4385664908 created "2023-08-09" @default.
- W4385664908 creator A5011761333 @default.
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- W4385664908 date "2023-08-08" @default.
- W4385664908 modified "2023-09-25" @default.
- W4385664908 title "Caspase-mediated nuclear pore complex trimming in cell differentiation and endoplasmic reticulum stress" @default.
- W4385664908 doi "https://doi.org/10.7554/elife.89066.1" @default.
- W4385664908 hasPublicationYear "2023" @default.
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