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- W4385666720 abstract "<p>TPST-1495 effectively increases survival and modulates the TME in APC<sup>min/+</sup> mice. <b>A,</b> Tumor counts in the small intestine of APC<sup>min/+</sup> mice. Mice were treated starting at 13 weeks of age for 3 weeks with TPST-1495 (100 mg/kg twice a day, orally), E7046 (150 mg/kg every day, orally), PF04418948 (100 mg/kg every day, orally), or Celecoxib (60 mg/kg every day, orally). Results are representative of multiple experiments with 7–10 mice. <b>B</b>, Kaplan–Meier curve of survival of APC<sup>min/+</sup> mice and log-rank Mantel–Cox <i>P</i> values of listed comparisons. Mice were ages to 13 weeks, then treated with as in A or with the combination of E7046 and PF04418948 at monotherapy doses, for 6 weeks. Survival was monitored longitudinally and mice were sacrificed as they became moribund. Results are representative of two similar experiments with 8 mice per group. <b>C</b>, IHC of tumor or hyperplasia excised from small intestines of mice from experiment in A. Quantification displays values from one tumor in each biological replicate. TPST-1495 every day and twice a day groups are concatenated because of limited tumor tissue in these groups. Mean and SD are depicted in all graphs and the Student two-sided <i>t</i> test was used to assess significance between individual groups. ****, <i>P</i> < 0.0001; ***, <i>P</i> < 0.001; **, <i>P</i> < 0.01; *, <i>P</i> < 0.05. BID, twice a day; QD, every day.</p>" @default.
- W4385666720 created "2023-08-09" @default.
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- W4385666720 date "2023-08-08" @default.
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- W4385666720 title "FIGURE 6 from Dual Blockade of EP2 and EP4 Signaling is Required for Optimal Immune Activation and Antitumor Activity Against Prostaglandin-Expressing Tumors" @default.
- W4385666720 doi "https://doi.org/10.1158/2767-9764.23905690.v1" @default.
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