FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385667032> ?p ?o ?g. }

• W4385667032 endingPage "e88460b8" @default.
• W4385667032 startingPage "e88460b8" @default.
• W4385667032 abstract "Topic: 2. Acute lymphoblastic leukemia - Clinical Background: T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 12–15% of newly diagnosed ALL cases. Due to intensive therapy, outcomes in T-ALL are steadily improving with 5-year event-free survival (EFS) reaching more than 80%. Acute lymphoblastic leukemia is thought to have distinctive features in Tunisian children and young adults. The analysis of T-ALL allowed a better study of their characteristics as well as their evolution after treatment. Aims: The aim of this study was to determine the clinical and biological characteristics of T-ALL and to the analysis of T-ALL to allow a better study of their characteristics as well as their evolution after treatment. Methods: In this study, we enrolled retrospectively all cases of patients under 30 years old, with T-ALL diagnosed in the hematology department of Hedi Chaker Hospital of Sfax, Tunisia, between January 2000 and December 2021. All patients were treated with the EORTC 58951 pediatric protocol. We studied the epidemiological characteristics (age, sex, clinical and biological signs). We also studied the therapeutic outcomes: complete remission, overall survival (OS), event-free survival (EFS), and relapse rate. Results: We enrolled 130 cases of T-ALL (33%) of all ALL diagnosed during this period. Forty-six cases (36%) of these T-ALL were aged more than 15 years. The sex ratio M/F was 2.1. A tumor syndrome was noted in 113 cases (88%), of which 37 cases were young adults (29%). Hyperleukocytosis of more than 100 G/L was detected in 47 cases (36%). Cytogenetic abnormalities were found in 42 patients (31%). On the 7th day of treatment with corticosteroids, 38% of cases were corticoresistant. According to risk group stratification, 73 cases (56%) were classified into medium risk 2 (MR2) and 57 cases (45%) into high risk (HR). The rate of complete remission (CR) was 86% (112 cases). The rate of toxic death was 27%. Allogeneic bone marrow transplantation was performed in 15 of 25 patients with CR of the HR group. Relapse occurred in 30 patients (27%). With a median follow-up of 159 months (13 years), OS and EFS at 5 years were respectively 54 and 53%. Summary/Conclusion: The frequency of T-ALL in our series (32%) is higher than those described in the literature (10 to 15%). This high frequency is also found in other Tunisian series as well as in the Tunisian multicenter study of 2005 (37%). The frequency of corticoresistance in our study (38%) is comparable to the literature (38 to 40%). The CR rate in our series was 86%, comparable to the literature (80 to 90%). However, the overall survival at 5 years was 54% lower than in the literature (70-80%), which could be explained by the high rate of toxic death (27%). Our therapeutic results could be improved by using other therapeutic arms particularly immuno-therapy such Nelarabine and CART-cells. Keywords: Young adult, Acute lymphoblastic leukemia, Children" @default.
• W4385667032 created "2023-08-09" @default.
• W4385667032 creator A5001360263 @default.
• W4385667032 creator A5001702374 @default.
• W4385667032 creator A5011684152 @default.
• W4385667032 creator A5019866212 @default.
• W4385667032 creator A5030931728 @default.
• W4385667032 creator A5039401154 @default.
• W4385667032 creator A5049435131 @default.
• W4385667032 creator A5051956051 @default.
• W4385667032 creator A5059218186 @default.
• W4385667032 creator A5065250582 @default.
• W4385667032 creator A5067377366 @default.
• W4385667032 creator A5087748661 @default.
• W4385667032 date "2023-08-01" @default.
• W4385667032 modified "2023-09-27" @default.
• W4385667032 title "PB1732: CLINICAL CHARACTERISTICS AND THERAPEUTIC RESULTS OF CHILDHOOD AND YOUNG ADULTS T - ACUTE LYMPHOBLASTIC LEUKEMIA IN SOUTH OF TUNISIA" @default.
• W4385667032 doi "https://doi.org/10.1097/01.hs9.0000973788.88460.b8" @default.
• W4385667032 hasPublicationYear "2023" @default.
• W4385667032 type Work @default.
• W4385667032 citedByCount "0" @default.
• W4385667032 crossrefType "journal-article" @default.
• W4385667032 hasAuthorship W4385667032A5001360263 @default.
• W4385667032 hasAuthorship W4385667032A5001702374 @default.
• W4385667032 hasAuthorship W4385667032A5011684152 @default.
• W4385667032 hasAuthorship W4385667032A5019866212 @default.
• W4385667032 hasAuthorship W4385667032A5030931728 @default.
• W4385667032 hasAuthorship W4385667032A5039401154 @default.
• W4385667032 hasAuthorship W4385667032A5049435131 @default.
• W4385667032 hasAuthorship W4385667032A5051956051 @default.
• W4385667032 hasAuthorship W4385667032A5059218186 @default.
• W4385667032 hasAuthorship W4385667032A5065250582 @default.
• W4385667032 hasAuthorship W4385667032A5067377366 @default.
• W4385667032 hasAuthorship W4385667032A5087748661 @default.
• W4385667032 hasBestOaLocation W43856670321 @default.
• W4385667032 hasConcept C107130276 @default.
• W4385667032 hasConcept C126322002 @default.
• W4385667032 hasConcept C187212893 @default.
• W4385667032 hasConcept C194409129 @default.
• W4385667032 hasConcept C205545832 @default.
• W4385667032 hasConcept C2776694085 @default.
• W4385667032 hasConcept C2778461978 @default.
• W4385667032 hasConcept C2909962599 @default.
• W4385667032 hasConcept C3018657049 @default.
• W4385667032 hasConcept C3019894029 @default.
• W4385667032 hasConcept C71924100 @default.
• W4385667032 hasConceptScore W4385667032C107130276 @default.
• W4385667032 hasConceptScore W4385667032C126322002 @default.
• W4385667032 hasConceptScore W4385667032C187212893 @default.
• W4385667032 hasConceptScore W4385667032C194409129 @default.
• W4385667032 hasConceptScore W4385667032C205545832 @default.
• W4385667032 hasConceptScore W4385667032C2776694085 @default.
• W4385667032 hasConceptScore W4385667032C2778461978 @default.
• W4385667032 hasConceptScore W4385667032C2909962599 @default.
• W4385667032 hasConceptScore W4385667032C3018657049 @default.
• W4385667032 hasConceptScore W4385667032C3019894029 @default.
• W4385667032 hasConceptScore W4385667032C71924100 @default.
• W4385667032 hasIssue "S3" @default.
• W4385667032 hasLocation W43856670321 @default.
• W4385667032 hasLocation W43856670322 @default.
• W4385667032 hasOpenAccess W4385667032 @default.
• W4385667032 hasPrimaryLocation W43856670321 @default.
• W4385667032 hasRelatedWork W2073483291 @default.
• W4385667032 hasRelatedWork W2339313676 @default.
• W4385667032 hasRelatedWork W2360128930 @default.
• W4385667032 hasRelatedWork W2410631588 @default.
• W4385667032 hasRelatedWork W2412346639 @default.
• W4385667032 hasRelatedWork W2472355036 @default.
• W4385667032 hasRelatedWork W2584383839 @default.
• W4385667032 hasRelatedWork W2768200593 @default.
• W4385667032 hasRelatedWork W3148126855 @default.
• W4385667032 hasRelatedWork W3205610956 @default.
• W4385667032 hasVolume "7" @default.
• W4385667032 isParatext "false" @default.
• W4385667032 isRetracted "false" @default.
• W4385667032 workType "article" @default.