FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385667053> ?p ?o ?g. }

• W4385667053 abstract "Abstract Inhibitory neurons embedded within mammalian neural circuits shape breathing, walking, chewing, and other rhythmic motor behaviors. At the core of the neural circuit controlling breathing is the preBötzinger Complex (preBötC), a nucleus in the ventrolateral medulla necessary for generation of inspiratory rhythm. In the preBötC, a recurrently connected network of glutamatergic Dbx1-derived (Dbx1 + ) neurons generates rhythmic inspiratory drive. Functionally and anatomically intercalated among preBötC Dbx1 + neurons are GABAergic (GAD1/2 + ) and glycinergic (GlyT2 + ) neurons, whose roles in breathing remain unclear. To elucidate the inhibitory microcircuits within preBötC, we first characterized the spatial distribution of molecularly-defined preBötC inhibitory subpopulations in double reporter mice expressing either the red fluorescent protein tdTomato or EGFP in GlyT2 + , GAD1 + , or GAD2 + neurons. We found that, in neonatal mice, the majority of preBötC inhibitory neurons expressed a combination of GlyT2 and GAD2 while a much smaller subpopulation also expressed GAD1. To determine the functional role of these subpopulations, we used holographic photostimulation, a patterned illumination technique with high spatiotemporal resolution, in rhythmically active medullary slices from neonatal Dbx1 tdTomato ;GlyT2 EGFP and Dbx1 tdTomato ;GAD1 EGFP double reporter mice. Stimulation of 4 or 8 preBötC GlyT2 + neurons during endogenous rhythm prolonged the interburst interval in a phase-dependent manner and increased the latency to burst initiation when bursts were evoked by stimulation of Dbx1 + neurons. In contrast, stimulation of 4 or 8 preBötC GAD1 + neurons did not affect interburst interval or latency to burst initiation. Instead, photoactivation of GAD1 + neurons during the inspiratory burst prolonged endogenous and evoked burst duration and decreased evoked burst amplitude. We conclude that the majority of preBötC inhibitory neurons express both GlyT2 and GAD2 and modulate breathing rhythm by delaying burst initiation while a smaller GAD1 + subpopulation shapes inspiratory patterning by altering burst duration and amplitude." @default.
• W4385667053 created "2023-08-09" @default.
• W4385667053 creator A5006216208 @default.
• W4385667053 creator A5014006910 @default.
• W4385667053 creator A5050615931 @default.
• W4385667053 date "2023-08-08" @default.
• W4385667053 modified "2023-09-25" @default.
• W4385667053 title "Inhibitory subpopulations in preBötzinger Complex play distinct roles in modulating inspiratory rhythm and pattern" @default.
• W4385667053 cites W1529085124 @default.
• W4385667053 cites W1573719564 @default.
• W4385667053 cites W1879018584 @default.
• W4385667053 cites W1963530163 @default.
• W4385667053 cites W1966167980 @default.
• W4385667053 cites W1977239542 @default.
• W4385667053 cites W1997953085 @default.
• W4385667053 cites W1999713747 @default.
• W4385667053 cites W2002701925 @default.
• W4385667053 cites W2009959567 @default.
• W4385667053 cites W2012509205 @default.
• W4385667053 cites W2012668389 @default.
• W4385667053 cites W2015386261 @default.
• W4385667053 cites W2016151414 @default.
• W4385667053 cites W2029078782 @default.
• W4385667053 cites W2030969925 @default.
• W4385667053 cites W2037688283 @default.
• W4385667053 cites W2040574649 @default.
• W4385667053 cites W2044179965 @default.
• W4385667053 cites W2044958838 @default.
• W4385667053 cites W2051304964 @default.
• W4385667053 cites W2054936551 @default.
• W4385667053 cites W2055887792 @default.
• W4385667053 cites W2058965831 @default.
• W4385667053 cites W2063630842 @default.
• W4385667053 cites W2063812431 @default.
• W4385667053 cites W2067551890 @default.
• W4385667053 cites W2067883939 @default.
• W4385667053 cites W2068707715 @default.
• W4385667053 cites W2072500831 @default.
• W4385667053 cites W2090951347 @default.
• W4385667053 cites W2091725272 @default.
• W4385667053 cites W2092246706 @default.
• W4385667053 cites W2094353622 @default.
• W4385667053 cites W2096006516 @default.
• W4385667053 cites W2097512647 @default.
• W4385667053 cites W2103479712 @default.
• W4385667053 cites W2104135721 @default.
• W4385667053 cites W2107554012 @default.
• W4385667053 cites W2115487032 @default.
• W4385667053 cites W2119693721 @default.
• W4385667053 cites W2124865189 @default.
• W4385667053 cites W2129032286 @default.
• W4385667053 cites W2138175169 @default.
• W4385667053 cites W2151686843 @default.
• W4385667053 cites W2273630161 @default.
• W4385667053 cites W2284343863 @default.
• W4385667053 cites W2304994747 @default.
• W4385667053 cites W2306521117 @default.
• W4385667053 cites W2346625225 @default.
• W4385667053 cites W2745309600 @default.
• W4385667053 cites W2792405568 @default.
• W4385667053 cites W2792962347 @default.
• W4385667053 cites W2801312539 @default.
• W4385667053 cites W2802602346 @default.
• W4385667053 cites W2898950880 @default.
• W4385667053 cites W2900987325 @default.
• W4385667053 cites W2918004902 @default.
• W4385667053 cites W2990626084 @default.
• W4385667053 cites W2995388315 @default.
• W4385667053 cites W3009276911 @default.
• W4385667053 cites W3083563689 @default.
• W4385667053 cites W3129901201 @default.
• W4385667053 cites W4220914976 @default.
• W4385667053 cites W4226497221 @default.
• W4385667053 cites W4231389227 @default.
• W4385667053 cites W4280646983 @default.
• W4385667053 cites W4282921115 @default.
• W4385667053 cites W4309410472 @default.
• W4385667053 cites W4315641962 @default.
• W4385667053 cites W4319461547 @default.
• W4385667053 doi "https://doi.org/10.1101/2023.08.07.552303" @default.
• W4385667053 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37609332" @default.
• W4385667053 hasPublicationYear "2023" @default.
• W4385667053 type Work @default.
• W4385667053 citedByCount "0" @default.
• W4385667053 crossrefType "posted-content" @default.
• W4385667053 hasAuthorship W4385667053A5006216208 @default.
• W4385667053 hasAuthorship W4385667053A5014006910 @default.
• W4385667053 hasAuthorship W4385667053A5050615931 @default.
• W4385667053 hasBestOaLocation W43856670531 @default.
• W4385667053 hasConcept C105702510 @default.
• W4385667053 hasConcept C118403218 @default.
• W4385667053 hasConcept C169760540 @default.
• W4385667053 hasConcept C170493617 @default.
• W4385667053 hasConcept C17077164 @default.
• W4385667053 hasConcept C24998067 @default.
• W4385667053 hasConcept C2777756961 @default.
• W4385667053 hasConcept C2778110749 @default.
• W4385667053 hasConcept C2779177108 @default.
• W4385667053 hasConcept C2780648746 @default.
• W4385667053 hasConcept C2781151714 @default.

• next