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• W4385667191 abstract "Topic: 2. Acute lymphoblastic leukemia - Clinical Background: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. This tumor has a good prognosis with cure rates of more than 80%. Therefore, epidemiological and therapeutic differences exist in terms of the phenotyping of ALL. The comparative analysis of B ALL and T ALL allowed a better differentiation of their characteristics as well as their evolution after treatment. Aims: The aim of this study is to compare the characteristics of B and T-ALL and predict the prognosis of these groups and their evolution after treatment. Methods: In this study, we enrolled retrospectively all cases of patients under 30 years old, with ALL diagnosed in the hematology department of Hedi Chaker Hospital, Sfax, Tunisia, between January 2000 and December 2021. The therapeutic protocol is EORTC 58951. We compared the epidemiological characteristics of B and T-ALL (age, sex, clinical and biological characteristics). We also compared the therapeutic outcomes of each phenotype of ALL: complete remission (CR), relapse rate, overall survival (OS), and event-free survival (EFS). Results: The comparative results of T and B-ALL were shown in the bellow table. - Characteristics TotalN= 395 LAL BN= 265 (67%) LAL TN=130 (33%) p Median age(years) 9 (1- 30) 7 (1-30) 13 (2-30) - Sex-ratio 1.58 1.38 2.1 - Tumor syndrome 297 (75%) 184 (71) 113 (88) <0.001 WBC ≥100G/L 74 (19%) 27 (10) 47 (36) <0.001 Corticoresistance 86 (22) 36 (14) 50 (38) <0.001 Complete remission 354 (90) 242 (91) 112 (86) <0.001 Failure remission 25 (6.5) 15 (6) 10 (8) - Relapse rate 116 (33) 86 (35) 30 (27) 0.084 OS at 5 years 63% 67% 54% 0.002 EFS at 5 years 58% 60% 53% 0.048 Summary/Conclusion: The frequency of T-ALL in our study (33%) is higher than those described in the literature (10 to 15%). The clinical and biological data of T-ALL in our study are characterized by more tumor syndrome and higher hyperleukocytosis than 100 G/L. The therapeutic results of T-ALL are also characterized by less frequency of corticosensitivity, complete remission, OS, and EFS. Although, there is less frequency of a relapse. Our results are compared to those in the literature. Keywords: ALL, Acute lymphoblastic leukemia, Phenotype, Children" @default.
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• W4385667191 date "2023-08-01" @default.
• W4385667191 modified "2023-09-27" @default.
• W4385667191 title "PB1749: COMPARATIVE STUDY OF B AND T-ALL IN CHILDREN, ADOLESCENTS, AND YOUNG ADULTS: CLINICAL CHARACTERISTICS AND THERAPEUTIC RESULTS" @default.
• W4385667191 doi "https://doi.org/10.1097/01.hs9.0000973856.55089.96" @default.
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