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- W4385667457 abstract "Topic: 30. Infections in hematology (incl. supportive care/therapy) Background: Carbapenem-resistant Enterobacteriaceae (CRE) infection is an urgent problem associated with mortality for hematological patients. Aims: The aim of this study was to demonstrate the importance of active CRE surveillance in the hematology ward and identify the risk factors for mortality in active CRE surveillance and non-active CRE surveillance patients. Methods: The retrospective cohort study identified 23832 hematological patients between 2019 and 2021. Propensity Score Matching was performed to match underling diseases and admission time in a ratio of 1:1:1 for three groups (detected CRE, undetected CRE and non-active CRE surveillance). Results: The positivity rate of active CRE surveillance among all samples was 2.1% (141/6735) and the incidence rate of detected CRE among all patients received active CRE surveillance was 4.8% (85/1789). The distribution among all the 141 isolates were Klebsiella pneumoniae (66.7%) and Escherichia coli (22.6%) and others (10.8%). The risk factors independently associated with positive result of active CRE surveillance were: accept the hematopoietic stem cell transplantation, hospital LOS ≥ 18 d, central venous catheter, treatment with steroid previous 3 months, exposure to antibiotics (ß-lactam/ß-lactamase inhibitor combinations, Echinocandins) previous 1 month, perianal skin ulceration previous 3 days, albumin < 33.4 g/L and neutropenia ≥ 7d. 26.5% patients in detected CRE group developed CRE infection. Cox regression showed that diarrhea within 3 days before CRE active surveillance and interleukin-6 ≥ 39.35pg/ml within 24 hours of CRE active surveillance were independent predictors of 90-day mortality. Summary/Conclusion:Klebsiella pneumoniae and Escherichia coli were the main strains for active CRE screening. The incidence of CRE infection was relatively elevated in detected CRE group. The active CRE surveillance may play a certain early warning role for 90-day mortality of patients, and should be implemented in the patients admitted in hematology department.Keywords: Risk factor, Drug resistance, Hematological malignancy" @default.
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- W4385667457 date "2023-08-01" @default.
- W4385667457 modified "2023-10-01" @default.
- W4385667457 title "P1510: INCIDENCE AND RISK FACTORS OF ACTIVE CARBAPENEM-RESISTANT ENTEROBACTERIACEAE SURVEILLANCE FOR PATIENTS ADMITTED TO HEMATOLOGY DEPARTMENT: A PROPENSITY SCORE MATCHING STUDY." @default.
- W4385667457 doi "https://doi.org/10.1097/01.hs9.0000972920.43634.eb" @default.
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