FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385667622> ?p ?o ?g. }

• W4385667622 endingPage "e5990023" @default.
• W4385667622 startingPage "e5990023" @default.
• W4385667622 abstract "Topic: 27. Thalassemias Background: Thalassemia comprises a heterogenous group of genetic disorders characterised by reduced or absent globin synthesis. Clinical phenotypes include thalassemia minor, intermediate and major, ranging from asymptomatic disorder to severe transfusion requirements. Despite the improvement in therapeutic management in the era of new agents such as luspatercept, splenectomy remains an important treatment option, especially in low income countries. However, splenectomy has been linked to thromboembolic complications in several studies, a factor that increases morbidity and mortality in these patients. Aims: In this meta-analysis we sought to provide pooled effect estimates regarding the impact of splenectomy on thrombosis, by retrieving relevant, available studies, in order to quantify the possible risk for thrombosis that arises from this procedure. Methods: We searched Pubmed, Cochrane library and grey literature from inception to the 20th of February 2023 for studies reporting on major and intermediate thalassemia patients who had undergone splenectomy and their matched controls who were not splenectomised. We recorded the incidence of thromboembolic complications in splenectomised versus non-splenectomised patients. Results were pooled with the use of a random-effects model. Odds ratios (OR) and 95% confidence intervals (CI) were calculated. RevMan 5.4 software was used for the statistical analysis and presentation of the results. Results: We collected data from six observational studies, 3 of which were prospective, in a total of 923 patients, 482 of whom were splenectomised. The random effects model meta-analysis revealed that the incidence of thrombosis was significantly higher in thalassemic patients with splenectomy compared to those without splenectomy [OR=7.59, CI (2.45-23.49)]. The heterogeneity of the included studies was low (I2=0). The test for overall effect confirmed statistical significance (P=0.0004). Venous thrombosis constituted the vast majority of thromboembolic events, the most common of which appeared to be portal vein thrombosis (41%). Summary/Conclusion: The present meta-analysis confirms a strong correlation between splenectomy and thrombotic events in patients with thalassemia major and intermediate. Splenectomised thalassemic patients presented with thrombosis 7.59 times more often than non-splenectomised patients. This result may have clinical implications and assist evidence-based therapeutic decisions and thromboprophylaxis management in the future.Keywords: Meta-analysis, Thalassemia, Thromboembolic events, Splenectomy" @default.
• W4385667622 created "2023-08-09" @default.
• W4385667622 creator A5068863090 @default.
• W4385667622 creator A5086368765 @default.
• W4385667622 creator A5092614116 @default.
• W4385667622 date "2023-08-01" @default.
• W4385667622 modified "2023-09-27" @default.
• W4385667622 title "P1455: THROMBOEMBOLIC EVENTS IN SPLENECTOMISED VERSUS NON-SPLENECTOMISED THALASSEMIA PATIENTS: A META-ANALYSIS OF OBSERVATIONAL STUDIES" @default.
• W4385667622 doi "https://doi.org/10.1097/01.hs9.0000972704.59900.23" @default.
• W4385667622 hasPublicationYear "2023" @default.
• W4385667622 type Work @default.
• W4385667622 citedByCount "0" @default.
• W4385667622 crossrefType "journal-article" @default.
• W4385667622 hasAuthorship W4385667622A5068863090 @default.
• W4385667622 hasAuthorship W4385667622A5086368765 @default.
• W4385667622 hasAuthorship W4385667622A5092614116 @default.
• W4385667622 hasBestOaLocation W43856676221 @default.
• W4385667622 hasConcept C120665830 @default.
• W4385667622 hasConcept C121332964 @default.
• W4385667622 hasConcept C126322002 @default.
• W4385667622 hasConcept C156957248 @default.
• W4385667622 hasConcept C23131810 @default.
• W4385667622 hasConcept C2776309230 @default.
• W4385667622 hasConcept C2777799968 @default.
• W4385667622 hasConcept C2780868729 @default.
• W4385667622 hasConcept C2780931953 @default.
• W4385667622 hasConcept C61511704 @default.
• W4385667622 hasConcept C71924100 @default.
• W4385667622 hasConcept C95190672 @default.
• W4385667622 hasConceptScore W4385667622C120665830 @default.
• W4385667622 hasConceptScore W4385667622C121332964 @default.
• W4385667622 hasConceptScore W4385667622C126322002 @default.
• W4385667622 hasConceptScore W4385667622C156957248 @default.
• W4385667622 hasConceptScore W4385667622C23131810 @default.
• W4385667622 hasConceptScore W4385667622C2776309230 @default.
• W4385667622 hasConceptScore W4385667622C2777799968 @default.
• W4385667622 hasConceptScore W4385667622C2780868729 @default.
• W4385667622 hasConceptScore W4385667622C2780931953 @default.
• W4385667622 hasConceptScore W4385667622C61511704 @default.
• W4385667622 hasConceptScore W4385667622C71924100 @default.
• W4385667622 hasConceptScore W4385667622C95190672 @default.
• W4385667622 hasIssue "S3" @default.
• W4385667622 hasLocation W43856676221 @default.
• W4385667622 hasLocation W43856676222 @default.
• W4385667622 hasOpenAccess W4385667622 @default.
• W4385667622 hasPrimaryLocation W43856676221 @default.
• W4385667622 hasRelatedWork W2099398129 @default.
• W4385667622 hasRelatedWork W2157817067 @default.
• W4385667622 hasRelatedWork W2275643845 @default.
• W4385667622 hasRelatedWork W2350928765 @default.
• W4385667622 hasRelatedWork W2383775094 @default.
• W4385667622 hasRelatedWork W2412786053 @default.
• W4385667622 hasRelatedWork W2415385872 @default.
• W4385667622 hasRelatedWork W2415751202 @default.
• W4385667622 hasRelatedWork W3091293703 @default.
• W4385667622 hasRelatedWork W3210549864 @default.
• W4385667622 hasVolume "7" @default.
• W4385667622 isParatext "false" @default.
• W4385667622 isRetracted "false" @default.
• W4385667622 workType "article" @default.