FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4385670053> ?p ?o ?g. }

• W4385670053 endingPage "S921" @default.
• W4385670053 startingPage "S920" @default.
• W4385670053 abstract "Introduction Schizophrenia (SZ) is a severe and frequent mental disorder that has multifactorial origins (genetic but also environmental vulnerability, gene environment interactions). Our team has shown that in France smoking is common among these patients and often begins before the onset of symptoms. This calls into question the hypothesis of self-medication of psychotic symptoms and cognitive disorders by tobacco consumption, and raises the question of specific interactions between nicotine consumption and the genes of the dopaminergic and cholinergic nicotinic systems, in particular with regard to adolescence, period of neurodevelopmental vulnerability. Objectives to study (i) the interactions between the DA system and exogenous nicotine in a pre-clinical mouse model (transgenic for DAT) (ii) the impact of smoking on the psychotic and clinical phenotype in a national cohort of SZ patients (iii) interactions between tobacco consumption and several genetic polymorphisms of the dopaminergic and nicotinic system in SZ population. Hypothesis: Disruption of the balance between DA and nicotine systems by nicotine consumption in adolescence may be a key neurobiological mechanism for the emergence of SZ disorders. Methods The characterization of the model is behavioral (anxiety, memory, social interactions, locomotion, motor coordination) but also biochemical. For the clinical approach, we exploit the clinical / cognitive / genetic data of a national cohort (Fondamental foundation) and another smaller and local cohort. Results We demonstrate, for the clinical study, that some clinical and cognitive characteristics are associated with tobacco use in schizophrenia patients, with more cognitive distubrances in smokers, against the self medication hypothesis. Genes envionment interactions also demonstrate associations with genes involved in dopaminergic system. Regarding the preclinical study, we show a gene environment interaction, as heterozygote mice for the DAT gene exposed to Nicotine durig a critical neurodevelopmental window ( adolescence) show a loss of familiarity in the social memory test and a loss of cognitive flexibility at the set shifting test, similar to what is found in schizophrenia. Conclusions TBetter characterization of patients with schizophrenia is necessary to better understand the physiopathology of this disease and explore new personalized preventive and therapeutical targets. We show that tobacco is associated with cognitive disturbances in schizophrenia patients, against selfmedication hypothesis; and in our animal model, that nicotine exposition during the adolescence combined to a moderate cortical and limbic hyperdopaminergia, is associated with persistent cognitive and social deficits, in favor of a gene environment interaction. Disclosure of Interest None Declared" @default.
• W4385670053 created "2023-08-09" @default.
• W4385670053 creator A5008529334 @default.
• W4385670053 creator A5044488751 @default.
• W4385670053 creator A5057642553 @default.
• W4385670053 creator A5059672839 @default.
• W4385670053 creator A5079628307 @default.
• W4385670053 date "2023-03-01" @default.
• W4385670053 modified "2023-10-16" @default.
• W4385670053 title "Tobacco and mental health- Deciphering the vulnerability to nicotine in patients with schizophrenia as a function of their dopamine neurotransmission genes: a clinical and preclinical study" @default.
• W4385670053 doi "https://doi.org/10.1192/j.eurpsy.2023.1946" @default.
• W4385670053 hasPublicationYear "2023" @default.
• W4385670053 type Work @default.
• W4385670053 citedByCount "0" @default.
• W4385670053 crossrefType "journal-article" @default.
• W4385670053 hasAuthorship W4385670053A5008529334 @default.
• W4385670053 hasAuthorship W4385670053A5044488751 @default.
• W4385670053 hasAuthorship W4385670053A5057642553 @default.
• W4385670053 hasAuthorship W4385670053A5059672839 @default.
• W4385670053 hasAuthorship W4385670053A5079628307 @default.
• W4385670053 hasBestOaLocation W43856700531 @default.
• W4385670053 hasConcept C104317684 @default.
• W4385670053 hasConcept C118552586 @default.
• W4385670053 hasConcept C126322002 @default.
• W4385670053 hasConcept C137183658 @default.
• W4385670053 hasConcept C15744967 @default.
• W4385670053 hasConcept C169760540 @default.
• W4385670053 hasConcept C169900460 @default.
• W4385670053 hasConcept C170493617 @default.
• W4385670053 hasConcept C188987157 @default.
• W4385670053 hasConcept C2776412080 @default.
• W4385670053 hasConcept C2779547902 @default.
• W4385670053 hasConcept C2908647359 @default.
• W4385670053 hasConcept C513476851 @default.
• W4385670053 hasConcept C54355233 @default.
• W4385670053 hasConcept C558461103 @default.
• W4385670053 hasConcept C69991583 @default.
• W4385670053 hasConcept C70410870 @default.
• W4385670053 hasConcept C71924100 @default.
• W4385670053 hasConcept C72563966 @default.
• W4385670053 hasConcept C86803240 @default.
• W4385670053 hasConcept C99454951 @default.
• W4385670053 hasConceptScore W4385670053C104317684 @default.
• W4385670053 hasConceptScore W4385670053C118552586 @default.
• W4385670053 hasConceptScore W4385670053C126322002 @default.
• W4385670053 hasConceptScore W4385670053C137183658 @default.
• W4385670053 hasConceptScore W4385670053C15744967 @default.
• W4385670053 hasConceptScore W4385670053C169760540 @default.
• W4385670053 hasConceptScore W4385670053C169900460 @default.
• W4385670053 hasConceptScore W4385670053C170493617 @default.
• W4385670053 hasConceptScore W4385670053C188987157 @default.
• W4385670053 hasConceptScore W4385670053C2776412080 @default.
• W4385670053 hasConceptScore W4385670053C2779547902 @default.
• W4385670053 hasConceptScore W4385670053C2908647359 @default.
• W4385670053 hasConceptScore W4385670053C513476851 @default.
• W4385670053 hasConceptScore W4385670053C54355233 @default.
• W4385670053 hasConceptScore W4385670053C558461103 @default.
• W4385670053 hasConceptScore W4385670053C69991583 @default.
• W4385670053 hasConceptScore W4385670053C70410870 @default.
• W4385670053 hasConceptScore W4385670053C71924100 @default.
• W4385670053 hasConceptScore W4385670053C72563966 @default.
• W4385670053 hasConceptScore W4385670053C86803240 @default.
• W4385670053 hasConceptScore W4385670053C99454951 @default.
• W4385670053 hasIssue "S1" @default.
• W4385670053 hasLocation W43856700531 @default.
• W4385670053 hasOpenAccess W4385670053 @default.
• W4385670053 hasPrimaryLocation W43856700531 @default.
• W4385670053 hasRelatedWork W2011685750 @default.
• W4385670053 hasRelatedWork W2021270229 @default.
• W4385670053 hasRelatedWork W2039514799 @default.
• W4385670053 hasRelatedWork W2064614701 @default.
• W4385670053 hasRelatedWork W2277677491 @default.
• W4385670053 hasRelatedWork W230921123 @default.
• W4385670053 hasRelatedWork W2416699510 @default.
• W4385670053 hasRelatedWork W2490758946 @default.
• W4385670053 hasRelatedWork W2803873201 @default.
• W4385670053 hasRelatedWork W2951909829 @default.
• W4385670053 hasVolume "66" @default.
• W4385670053 isParatext "false" @default.
• W4385670053 isRetracted "false" @default.
• W4385670053 workType "article" @default.